Graduate School of Frontier Biosciences, Osaka University

Japanese

"Molecular organization of the endocannabinoid signaling system in the superficial spinal dorsal horn of rodents" Dr. Miklós Antal (University of Debrecen, Debrecen, Hungary)

Date/Time

October 7, 15:30-16:30


Place

Seminar Room (3F), Nanobiology building


Speaker

Dr. Miklós Antal
Professor and Chairman, Department of Anatomy, Histology and Embryology, Faculty of Medicine, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary

Title

Molecular organization of the endocannabinoid signaling system in the superficial spinal dorsal horn of rodents

Abstract

Extensive research in recent years has consolidated our view on endogenous cannabinoids as powerful regulators of synaptic function throughout the CNS. It is well established that endocannabinoids function as retrograde messengers. They are released from neurons in activity dependent manners and modulate synaptic transmission through presynaptic cannabinoid CB1 receptors. Endogenous cannabinoid signaling plays major roles in the modulation of various functions of the CNS including pain processing in the superficial spinal dorsal horn. Dr. Antal will present their findings concerning the molecular organization of the endocannabinoid signaling apparatus in neural circuits underlying pain processing in the superficial spinal dorsal horn. Special attention will be given to the participation of astrocytes in the spinal edocannabinoid signaling mechanisms.