Graduate School of Frontier Biosciences, Osaka University

Japanese

From hibernation to proliferation: Modulating centromere and kinetochore function across cell state
Iain Cheeseman (MIT)

Date/Time

November 26, 2018 (Mon), 16:30-17:30

Place

2F Seminar Room, BioSystems Building

Speaker

Iain Cheeseman (MIT)

Title

From hibernation to proliferation: Modulating centromere and kinetochore function across cell state

Abstract

The macromolecular kinetochore structure plays an essential role in chromosome segregation by mediating chromosome-microtubule interactions. Prior work has analyzed centromere and kinetochore function primarily in rapidly dividing cell types. However, recent work indicates that the kinetochore is modulated within the same organism, with kinetochore composition and function changing over the cell cycle, during meiosis and development, and across diverse physiological situations. This plasticity appears to be critical for the kinetochore machine to flexibly adapt to diverse situations and functional requirements. I will discuss specific examples of how kinetochore function is modulated under different physiological contexts. In particular, I will discuss our work to understand how centromere and kinetochore function is maintained during extended periods of cell cycle arrest to ensure that cells are able to undergo future proliferation following release from this hibernation.

Host

Tatsuo Fukagawa
Tel: 06-6879-4428
E-mail: tfukagawa@fbs.osaka-u.ac.jp


If you want to speak Dr. Cheeseman in person, please let me know. I will arrange the Interview with him.


http://www.fbs.osaka-u.ac.jp/eng/seminar/seminar/images/fbs-seminar-fukagawa-20181026-b.pdf