Graduate School of Frontier Biosciences, Osaka University


New insights into mitotic chromosome assembly and structure
William C Earnshaw (Univ Edinburgh, UK)

We will have a seminar by Prof. Bill Earnshaw (Univ Edinburgh) on Jun 22. He is a top runner in the filed of chromosome biology. If you have interests on the his talk, please join us.


Jun 22, 2017 (Thu), 15:00-16:00


2F Seminar room, BioSystems Building


William C Earnshaw (Univ Edinburgh, UK)


New insights into mitotic chromosome assembly and structure


The discovery of mitotic chromosomes by Flemming in 1882 established a major question in Cell Biology that remains unanswered all of these years later: How does the interphase nucleus transform itself into the thread-like mitotic chromosomes that segregate the genome in mitosis? I will discuss some work from our lab and those of our collaborators suggesting that mitotic chromosome formation involves two processes; compaction of the chromatin, and a functionally distinct architectural remodeling that disassembles the structure of the interphase nucleus and causes a helical transformation that results in the formation of individual chromatids. I will also describe recent work from our group that yielded the very surprising finding that in fact, only about 60-70 percent of those chromosomes observed by Flemming was made up of chromatin. A significant fraction - possibly up to 40% - of the volume of mitotic chromosomes is actually comprised of a mysterious highly complex layer that surrounds the chromatin. This chromosome periphery compartment helps to keep chromosomes separate in mitosis and has an important role in efficient reactivation of the nucleoli after mitosis.


Tatsuo Fukagawa
Tel: 06-6879-4428

If you want to speak Bill in person, please let me know. I will arrange the interview with him.