Graduate School of Frontier Biosciences, Osaka University

Japanese

Colloquium 188

Regulation of the formation of cullin 4-RING ubiquitin ligases in nucleotide excision repair

Speaker Masafumi Saijo (Associate Professor, Human Cell Biology Group)
Title Regulation of the formation of cullin 4-RING ubiquitin ligases in nucleotide excision repair
Date Wed., June 20, 2018, 12:15~13:00
Place 2F Seminar room, BioSystems Building
Host Masafumi Saijo (Associate Professor, Human Cell Biology Group)
Tel: 06-6877-9136
E-mail: saijom[at]fbs.osaka-u.ac.jp

Abstract

Nucleotide excision repair (NER) removes a wide range of structurally unrelated bulky, helix-distorting DNA lesions, including UV-induced cyclobutane pyrimidine dimers as well as chemical carcinogens. NER comprises two subpathways: global genome NER (GG-NER) and transcription-coupled NER (TC-NER). DDB2 and CSA have seven WD40 repeat motifs and form cullin 4-RING ubiquitin ligases (CRL4s). CRL4-DDB2 and CRL4-CSA function in GG-NER and TC-NER, respectively. In this colloquium, I will present about recent findings on the formation of these CRLs.


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