Graduate School of Frontier Biosciences, Osaka University

Japanese

Colloquium 243

Speaker Shingo Miyawaki (Specially Appointed Assistant Professor ( Laboratory of Epigenome Dynamics ( Tachibana Lab.))
Title Two exon-type Sry is essential for mouse male development
Date Thu., July 2 , 2020, 12:15~13:00
Place Zoom (on line):We will announce the Meeting URL, ID and Password until the day before the each colloquium by Email.
Host Name:Shunsuke Kuroki (Associate Processor (Tachibana Lab.)       
Tel :06-6879-4672
E-mail:skuroki@fbs.osaka-u.ac.jp
Language Japanese

Title/Abstract

Two exon-type Sry is essential for mouse male development

The mammalian sex-determining gene Sry induces male development. Since its discovery 30 years ago, Sry has been believed to be a single-exon. Here, we identified a cryptic second exon of mouse Sry and a corresponding novel transcript, two-exon Sry (Sry-T). XY mice lacking Sry-T were sex-reversed, and ectopic expression of Sry-T in XX mice induced male development. Our findings suggest that Sry-T is necessary and sufficient in mouse male development. I will introduce recent progress on the studies of Sry exon2 and Sry-T.


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