Graduate School of Frontier Biosciences, Osaka University


Colloquium 242

Speaker Yasushi Hiraoka (Professor (Nuclear Dynamics Group, FBS (Hiraoka Lab.))
Title Phase separation drives pairing of homologous chromosomes
Date Thu., June. 25, 2020, 12:15~13:00
Place Zoom (on line):We will announce the Meeting URL, ID and Password until the day before the each colloquium by Email.
Host Name:Haruhiko Asakawa   
Tel :06 6879 4621
Language Japanese


Phase separation drives pairing of homologous chromosomes

Pairing of homologous chromosomes is crucial for ensuring accurate segregation of chromosomes during meiosis. Molecular mechanisms of homologous chromosome pairing in meiosis have been extensively studied in the fission yeast Schizosaccharomyces pombe. In this organism, meiosis-specific noncoding RNA transcribed from specific genes accumulates at the respective gene loci during pairing of homologous chromosomes. Recent studies have demonstrated that chromosome-associated RNA-protein complexes mediate meiotic pairing of homologous loci through phase separation.