Graduate School of Frontier Biosciences, Osaka University

Japanese

Colloquium 214

Speaker Eiki Yamashita (Associate Professor(Laboratory of Supramolecular Crystallography / Institute for Protein Research))
Title Structure of the tripartite efflux pump MexAB-OprM spanning two membranes
Date Thu., June 20, 2019, 12:15~13:00
Place 2F Seminar room, BioSystems Building
Host Name: Atsushi Nakagawa        
Tel :06-6879-8635
E-mail:atsushi@protein.osaka-u.ac.jp
Language Japanese










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Title/Abstract

Structure of the tripartite efflux pump MexAB-OprM spanning two membranes

Tripartite efflux pumps play a major role in multidrug resistance in Gram-negative bacteria. The MexAB-OprM efflux pump, which is constitutively expressed, contributes to intrinsic resistance of Pseudomonas aeruginosa to various antimicrobials. Recently, we determined the whole structure of MexAB-OprM. In this colloquium, I will present the suggested mechanisms for complex formation and drug efflux on the basis of the structure.


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