Graduate School of Frontier Biosciences, Osaka University

Japanese

Colloquium 210

Speaker Mashun Onishi (Graduate student, D5/5・JSPS Research Fellow DC2(Laboratory of Mitochondrial Dynamics, Graduate School of Frontier Biosciences))
Title Regulation of mitochondria-specific autophagy via an endoplasmic reticulum membrane protein biogenesis pathway
Date Thu., May. 9, 2019, 12:15~13:00
Place 2F Seminar room, BioSystems Building
Host Contact:Koji Okamoto       
Tel :06-6879-7970
E-mail:kokamoto@fbs.osaka-u.ac.jp
Language English












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Title/Abstract

Regulation of mitochondria-specific autophagy via an endoplasmic reticulum membrane protein biogenesis pathway

  Selective clearance of excess or unhealthy mitochondria is a fundamental process conserved from yeast to humans, contributing to mitochondrial quantity and quality control. This catabolic event primarily depends on "autophagy", a cellular self-eating pathway that mediates transport of cytoplasmic components to lysosomes for degradation, and is thus called "mitophagy". Defects in mitophagy are associated with a myriad of disorders such as neurodegeneration, heart/liver failure, aging, and cancer, underscoring the physiological relevance. Previous studies have revealed multiple key molecules that establish the selectivity of mitophagy, opening a new avenue to understand the evolutionarily conserved fundamental principles of mitophagy at the molecular level. However, it still remains largely unclear how the activation of these key factors is regulated upon mitophagy. Using budding yeast as a model organism, we provide evidence suggesting an unexpected link between mitophagy and an endoplasmic reticulum (ER) membrane protein biogenesis pathway. In this seminar, possible mechanisms regulating mitochondrial clearance through factors on the neighboring but distinct organelle will be discussed.


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