Graduate School of Frontier Biosciences, Osaka University

Japanese

Colloquium

The 180th Colloquium Info: Hiroshima Michio(RIKEN QBiC Laboratory for Cell Signaling Dynamics・Senior Scientist)

Speaker Hiroshima Michio(RIKEN QBiC Laboratory for Cell Signaling Dynamics・Senior Scientist)
Title "High-throughput live-cell single-molecule imaging and its pharmacological application"
Date Wed. Jan. 24,2017 12:15~
Room 2F Seminar room, Biosystems Building, FBS
Host Contact:Yukihiro Miyanaga (Assistant Professor, Laboratory of Single Molecule Biology)       
Tel :4611
E-mail:miyanaga@fbs.osaka-u.ac.jp












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Detail

Speaker:Hiroshima Michio(RIKEN QBiC Laboratory for Cell Signaling Dynamics・Senior Scientist)

Affiliation:RIKEN QBiC Laboratory for Cell Signaling Dynamics
 
Title:"High-throughput live-cell single-molecule imaging and its pharmacological application" 

Abstract:
       Single-molecule imaging in cells enables a direct observation of individual signaling molecules and acquisition of spatiotemporal information of their behaviors and interactions. A mechanism of molecular dynamics and kinetics in cell signaling has been quantitatively revealed. However, the effective method has hardly applied to comprehensive measurement because conventional single-molecule imaging depends on a lot of specific expertise. Therefore, we automated all the processes of single-molecule microscopy, achieving expertise-free operation and high-throughput measurement. Applications of the apparatus can be extended not only to investigations of whole cell-signaling pathway but also to pharmacological study by single-molecule drug screening.


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Contact:Yukihiro Miyanaga (Assistant Professor, Laboratory of Single Molecule Biology)
Tel :4611
E-mail:miyanaga@fbs.osaka-u.ac.jp
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