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Integrated Biology Laboratories Pathology Division (Prof. Nakano)
Nanobiology Laboratories
Soft Biosystem Group
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Research Group of Lipid Biosignals
Biomolecular Dynamics Group
Developmental Biology Group
Chromosome Replication Group

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Laboratory of Genetics
Pathology Division
KOKORO-Biology Group
Cellular Biology Group

Organismal Biosystems Laboratories
Laboratory of Developmental Immunology
Developmental Genetics Group
Human Cell Biology Group
Medicine and Pathophysiology Group

Neuroscience Laboratories
Visual Neuroscience Group
Developmental and Functional Neuroscience Group
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Cellular and Molecular Neurobiology Group
Synaptic Plasticity Group

Biophysical Dynamics Laboratories
Physiological Laboratory
Nonequilibrium Physics Group
Functional Proteomics Group
Nano-Biophotonics Group

Biomedical Engineering Laboratories
Systems Neuroscience Group
Department of Molecular Genetics
Laboratory of Intercellular Communications
Laboratory of Stem Cell Research
Laboratory of Protein Informatics
Laboratory of Biocatalysis Science

Collaborative institutes
Laboratory of Immune Regulation Chugai Pharmaceutical CO.,LTD.
Optical Nano Device Group
OMRON Corporation

Lab. Members

Toru NAKANO Professor
Shintaro NOMURA Associate Professor
Tohru KIMURA Associate Professor
Kenji KITAJIMA Assistant Professor
Eiko SAKAI Assistant Professor
Satomi MIYAGAWA Postdoctoral Fellow
Toshinobu NAKAMURA Postdoctoral Fellow
Atsushi IKEDA Postdoctoral Fellow
Ayuko SATO Postdoctoral Fellow
Masato TANAKA Graduate StudentD4
Zheng JIE Graduate StudentD3
Kazushige MURAYAMA Graduate StudentD2
Shoko WATANABE Graduate StudentD1
Keisuke KITA Graduate StudentD1
Naoki SHIBATANI Graduate StudentM2
Hiroki UMEHARA Graduate StudentM1
Maya TOMOOKA Graduate StudentM1
Hilo YEN Graduate StudentM1
Noriko ASADA Technical Staff
Megumi IKEUCHI Technical Staff
Aya MIZOGAMI Secretary

Publication list
  1. Tanaka T, Zheng J, Kitajima K, Kita K, Yoshikawa H, Nakano T
    Differentiation Status Dependent Function of FOG-1
    Genes to Cells, in press, 2004

  2. Horie Y, Suzuki A, Kataoka E, Sasaki T, Hamada K, Sasaki J, Mizuno K, Hasegawa G, Kishimoto H, Iizuka M, Naito M, Enomoto K, Watanabe S, Mak TW, Nakano T
    Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas
    J Clin Invest, 113: 1774-1783, 2004

  3. Kuramochi-Miyagawa K, Kimura T, Ijiri T, Asada N, Fujita Y, Ikawa M, Isobe T, Iwai N, Okabe M, Deng W, Lin H, Matsuda Y, Nakano T
    mili, a mammalian member of piwi family gene, is essential for spermatogenesis
    Development, 131:839-849, 2004

  4. Nakano T
    Hematopoietic stem cells: generation and manipulation
    Trends Immunol, 24: 589-594, 2003

  5. Ueno H, Sakita-Ishikawa M, Morikawa Y, Nakano T, Kitamura T, Saito M.
    A stromal cell-derived membrane protein that supports hematopoietic stem cells
    Nature Immunol, 4:457-63, 2003

  6. Kimura T, Suzuki A, Fujita Y, Yomogida K, Lomeli H, Asada N, Ikeuchi M, Nagy A, Mak TW, Nakano T.
    Conditional loss of PTEN leads to testicular teratoma and enhances embryonic germ cell production
    Development, 130: 1691-1700, 2003

  7. Suzuki A, Kaisho T, Ohishi M, Tsukio-Yamaguchi M, Tsubata T, Koni PA, Sasaki T, Mak TW, Nakano T.
    Critical roles of Pten in B cell homeostasis and immunoglobulin class switch recombination
    J Exp Med, 197: 657-67, 2003

  8. Suzuki A, Itami A, Ohishi M, Inoue T, Komazawa N, Senoo H, Sasaki T, Takeda J, Manabe M, Mak TW, Nakano T.
    Keratinocyte-specific Pten deficiency results in epidermal hyperplasia, accelerated hair follicle morphogenesis and tumor formation
    Cancer Res, 63:674-81, 2003

  9. Kimura T, Ito C, Watanabe S, Takahashi T, Ikawa M, Yomogida K, Ikeuchi M, Asada N, Fujita Y, Matsumiya K, Okuyama A, Okabe M, Toshimori K, Nakano T.
    Mouse Germ Cell-Less as an essential component for nuclear integrity
    Mol Cell Biol, 23: 1304-15, 2003

  10. Kitajima K, Masuhara M, Era T, Enver T, Nakano T.
    GATA-2 and GATA-2/ER display opposing activities in the development and differentiation of blood progenitors.
    EMBO J, 21:3060-69, 2002

  11. Iwai N, Kitajima K, Sakai K, Kimura T, Nakano T.
    Alteration of cell adhesion and cell cycle properties of ES cells by an inducible dominant interfering Myb mutant.
    Oncogene, 20:1425-34, 2001

  12. Suzuki A, Tsukio-Yamaguchi M, Ohteki T, Sasaki T, Kaisho T, Kimura Y, Yoshida R, Wakeham A, Higuchi T, Fukumoto M, Tsubata T, Ohashi P, Koyasu S, Penninger J M, Nakano T. (corresponding author), Mak T W.
    T-cell specific loss of PTEN leads to defects in central and peripheral tolerance.
    Immunity, 14:523-34, 2001

  13. Era T, Takagi Y, Takahashi T, Bories J C, Nakano T.
    Characterization of hematopoietic lineage specific gene expression by ES cell in vitro differentiation induction system.
    Blood, 95: 870-878, 2000

  14. Takahashi T, Suwabe N, Dai P, Yamamoto M, Ishii S, Nakano T.
    Inhibitory interaction of c-Myb and GATA-1 via transcriptional co-activator CBP.
    Oncogene, 19:134-40, 2000

  15. Motoyama N, Kimura T, Takahashi T, Watanabe T, Nakano T.
    bcl-x prevents apoptotic cell death of both primitive and definitive erythrocytes at the end of maturation.
    J Exp Med, 189: 1691-1698, 1999

  16. Cho S K, Webber T D, Carlyle J R, Nakano T, Lewis S M, Zuniga-Pflucker J-C.
    Functional characterization of B lymphocytes generated in vitro from embryonic stem cells.
    Proc Natl Acad Sci USA, 96: 9797-9802, 1999

  17. Era T, Takahashi T, Sakai K, Kawamura K, Nakano T.
    Thrombopoietin enhances proliferation and differentiation of murine yolk sac erythroid progenitors.
    Blood, 89:1207-1213, 1997

  18. Nakano T, Kodama H, Honjo T.
    In vitro development of primitive and definitive erythrocytes from different precursors.
    Science, 272:722-724, 1996

  19. Nakano T, Kodama H, Honjo T.
    Generation of lymphohematopoietic cells from embryonic stem cells in culture.
    Science, 265:1098-1101, 1994

  20. Tashiro K, Tada H, Shirozu M, Heilker R, Nakano T, Honjo T.
    Signal sequence trap: A cloning strategy for secreted proteins and type I transmembrane proteins.
    Science, 261:600-603, 1993

  21. Nakano T, Graf T.
    Identification of genes differentially expresssed in two types of v-myb-transformed avian myelomonocytic cells.
    Oncogene, 7:527-534, 1992

  22. Introna M, Golay J, Frampton J, Nakano T, Ness S A, Graf T.
    Mutations in v-myb alter the differentiation of myelomonocytic cells transformed by the oncogene.
    Cell, 63:1287-1297, 1990

  23. Nakano T, Waki N, Asai H, Kitamura Y.
    Different repopulation profile between erythroid and nonerythroid progenitor cells in genetically anemic W/Wv mice after bone marrow transplantation.
    Blood, 74:1552-1556, 1989

  24. Nakano T, Waki N, Asai H, Kitamura Y.
    Lymphoid differentiation of the hematopoietic stem cell that reconstitutes total erythropoiesis of a genetically anemic W/Wv mouse.
    Blood, 73:1175-1179, 1989

  25. Nakano T, Waki N, Asai H, Kitamura Y.
    Effect of 5-fluorouracil on "primitive" hematopoietic stem cells that reconstitute whole erythropoiesis of genetically anemic W/Wv mice.
    Blood, 73:425-430, 1989

  26. Nakano T, Waki N, Asai H, Kitamura Y.
    Long term monoclonal reconstitution of erythropoiesis in genetically anemic W/Wv mice by injection of 5-fluorouracil treated bone marrow cells of Pgk-1b/Pgk-1a mice.
    Blood, 70:1758-1763, 1987

  27. Hamaguchi Y, Kanakura Y, Fujita J, Takeda S, Nakano T, Tarui S, Honjo T, Kitamura Y.
    Interleukin 4 as an essential factor for in vitro clonal growth of murine connective tissue type mast cells.
    J Exp Med, 165:268-273, 1987

  28. Nakano T, Sonoda T, Hayashi C, Yamatodani A, Kanayama Y, Yamamura T, Asai H, Yonezawa T, Kitamura Y, Galli S J.
    Fate of bone marrow derived cultured mast cells after intracutaneous, intraperitoneal and intravenous transfer into mast cell-deficient W/Wv mice; evidence that cultured mast cells can give rise to both connective tissue type and mucosal mast cells.
    J Exp Med, 162:1025-1043, 1985

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