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Integrated Biology Laboratories Pathology Division (Prof. Nakano)
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Laboratory of Immune Regulation Chugai Pharmaceutical CO.,LTD.
Optical Nano Device Group
OMRON Corporation

Professor NAKANO, Toru, MD, PhD +81-6-6879-3720
Associate Prof. NOMURA, Shintaro, PhD +81-6-6879-3722
Assistant Prof. MIYAKAWA, Satomi, PhD +81-6-6879-3722
Assistant Prof. SAKAI, Eiko, PhD +81-6-6879-3722

FAX +81-6-6879-3729
Postal Mail Address Graduate school of Frontier Biosciences, Osaka University
2-2 Yamada-oka, Suita, Osaka 565-0871 Japan
For more information http://www.fbs.osaka-u.ac.jp/labs/nakano/

Our major interest is ?gWhat is stem cell??h We are currently studying how stem cells are maintained and how stem cells are differentiated. Based on the molecular understandings of stem cell systems, we hope to establish novel methods to manipulate stem cell systems for regenerative medicine.

1 Molecular understandings of ?gstemness?h
The most striking and specific feature of stem cells is their ability to maintain immaturity. There have been reported that some specific signaling cascades play crucial roles in stem cell systems. At the same time, common signals are also important in various stem cell systems. Our research interest is how common signals control “stemness”.

2 Transcriptional control of blood cell formation
Hematopoietic system is a typical stem cell systems which has been a top runner of stem cell field. More than eight lineages of blood cells are produced from single immature hematpoietic cells and the process is tightly controlled by transcriptional regulation. To analyze the transcriptional control of hematopoiesis, we have developed a method to induce differentiation from mouse ES cells to blood cells by co-culturing on OP9 stroma cells (OP9 system). We are studying how blood cell differentiation is controlled by a lot of transcription factors.

3 Development of germ lineage cells
Germ cells are special cells which can transmit genetic information from generation to generation. And the differentiation status of the cells is fascinating since the cells can be “de-differentiated” to pluripotent stem cells under an appropriate circumstance. Molecular mechanisms of germ cell development and de-differentiation would give a good wealth of information on cell commitment, maturation and re-programming.

4 Development of novel methods to manipulate stem cell systems
Based on the above-mentioned studies, we hope to develop novel methods to manipulate stem cell systems for regenerative medicine.

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