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Name |
Email |
Telephone |
| Professor |
NAKANO, Toru, MD,
PhD |
 |
+81-6-6879-3720 |
| Associate Prof. |
NOMURA,
Shintaro, PhD |
 |
+81-6-6879-3722 |
| Assistant Prof. |
MIYAKAWA, Satomi, PhD |
|
+81-6-6879-3722 |
| Assistant Prof. |
SAKAI,
Eiko, PhD |
|
+81-6-6879-3722 |
Our major interest is ?gWhat is stem cell??h We are currently studying how stem cells are maintained and how stem cells are differentiated. Based on the molecular understandings of stem cell systems, we hope to establish novel methods to manipulate stem cell systems for regenerative medicine.
| 1 |
Molecular understandings of ?gstemness?h |
| The most striking and specific
feature of stem cells is their ability to maintain
immaturity. There have been reported that some specific
signaling cascades play crucial roles in stem cell
systems. At the same time, common signals are also
important in various stem cell systems. Our research
interest is how common signals control “stemness”. |
| 2 |
Transcriptional control of blood cell formation |
| Hematopoietic
system is a typical stem cell systems which has been
a top runner of stem cell field. More than eight lineages
of blood cells are produced from single immature hematpoietic
cells and the process is tightly controlled by transcriptional
regulation. To analyze the transcriptional control
of hematopoiesis, we have developed a method to induce
differentiation from mouse ES cells to blood cells
by co-culturing on OP9 stroma cells (OP9 system). We
are studying how blood cell differentiation is controlled
by a lot of transcription factors. |
| 3 |
Development of germ lineage cells |
| Germ cells are special cells
which can transmit genetic information from generation
to generation. And the differentiation status of the
cells is fascinating since the cells can be “de-differentiated” to
pluripotent stem cells under an appropriate circumstance.
Molecular mechanisms of germ cell development and de-differentiation
would give a good wealth of information on cell commitment,
maturation and re-programming. |
| 4 |
Development of novel methods to manipulate stem cell systems |
| Based on the above-mentioned
studies, we hope to develop novel methods to manipulate
stem cell systems for regenerative medicine. |
|
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