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Organismal Biosystems Laboratories Developmental Genetics Group (Prof. Hamada)
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Biomedical Engineering Laboratories
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Department of Molecular Genetics
Laboratory of Intercellular Communications
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Laboratory of Protein Informatics
Laboratory of Biocatalysis Science

Collaborative institutes
Laboratory of Immune Regulation Chugai Pharmaceutical CO.,LTD.
Optical Nano Device Group
OMRON Corporation

  Publications

  1. Nakai, S., Kawano, H., Tamai, T., Nishii, M., Kuno, J., Nagata, A., Jishage, K., Fujii, H., Hamada, H., Kawamura, K., Shiba, K. and Noda, T. (1995). The POU-domain transcription factor Brn-2 is required for the determination of specific neuronal lineages in the hypothalamus of the mouse. Genes Dev. 9, 3109-3121.

  2. Saijoh, Y., Fujii, H., Meno, C., Sato, M., Hirota, H., Ikeda, M., Nagamatsu, S. and Hamada, H. (1996). Identification of putative downstream genes of Oct-3, a pluripotent cell-specific transcription factor. Genes Cells 1, 239-252.

  3. Meno,C., Saijoh, Y., Fujii, H., Ikeda, M., Yokoyama, T., Yokoyama, M., Toyoda, Y. and Hamada, H. (1996). Left-right asymmetric expression of the TGF b-family member lefty in mouse embryos. Nature 381, 151-155.

  4. Okazawa, H., Imafuku, I., Minowa, M., Kanazawa, I., Hamada, H. and Mouradian, M.M. (1996). POU transcription factors differentially regulate the expression of DIA dopamine receptor gene. Proc. Natl. Acad. Sci. USA 93, 11933-11937.

  5. Hagino-Yamagishi, K., Saijoh, Y., Ikeda, M. and Hamada, H. (1997). Predominant expression of Brn-2 transcription factor in postmitotic neurons of developing mouse cortex. Brain Res. 752, 261-268.

  6. Fujii, H., Sato, T., Kaneko, S., Goto, O., Fujii-Kuriyama, Y., Osawa, K., Kato, S. and Hamada, H. (1997). Metabolic inactivation of retinoic acid by a novel P450 differentially expressed in developing mouse embryos. EMBO J. 16, 4163-4173.

  7. Meno, C., Ito, Y., Saijoh, Y., Matsuda, Y., Tashiro, K. and Hamada, H. (1997). Two closely-related left-right asymmetrically-expressed genes, lefty-1 and lefty-2 : Their distinct expression domains, chromosomal linkage and direct neuralizing activity in Xenopus embryos. Genes Cells 2, 513-524.

  8. Mitsuya, K., Meguro, M., Sui, H., Schulz, T.C., Kugoh, H., Hamada, H., and Oshimura, M. (1998). Epigenetic reprogramming of the human H19 gene in mouse embryonic cells does not erase the primary parental imprinting. Genes Cells 3, 245-255.

  9. Meno, C., Shimono, A., Saijoh, Y., Yashiro, K., Mochida, K., Ohishi, S., Noji, S., Kondoh, H. and Hamada, H. (1998). lefty-1 is required for left-right determination as a regulator of lefty-2 and nodal. Cell 94, 287-297.

  10. Yoshioka, H., Meno C., Koshiba, K., Sugihara, M., Itoh, H., Ishimaru, Y., Inoue, T., Ohuchi, H., Semina, E.V., Murray, J.C., Hamada, H., and Noji, S. (1998). Ptx2, a bicoid homeobox gene, is involved in a Lefty-signaling pathway in determination of left-right asymmetry. Cell 94, 299-305.

  11. Hagino-Yamagishi, K., Saijoh, Y., Yamazaki, Y., Yazaki, K., and Hamada, H. (1998). Transcriptional regulaory region of Brn-2 required for the expression in olfactory epithelial cells.Dev. Brain Res. 109, 77-89.

  12. Mochizuki, T., Saijoh, Y.,Tsuchiya, K., Shirayoshi, Y., Takai, S., Taya, C., Yonekawa, H., Yamada, K., Nihei, H., Nakatsuji, N., Overbeek, P., Hamada, H., and Yokoyama, T. (1998). Cloning of inv, a gene that controls left/right asymmetry and kidney development. Nature 395, 177-181.

  13. Saijoh, Y., Adachi, H., Mochida, K., Ohishi, S.,Hirao, A., and Hamada, H. (1999) Distinct transcriptional regulatory mechanisms underlie left-right asymmetric expression of lefty-1 and lefty-2. Genes Dev. 13, 259-269.

  14. Adachi, H., Saijoh, Y., Mochida, K., Ohishi, S., Hashiguchi, H., Hirao, A., and Hamada, H. (1999). Determination of left-right asymmetric expression of nodal by a left side-specific enhancer with sequence homology to a lefty-2 enhancer. Genes Dev. 13, 1589-1600.

  15. Nishino, J., Mochida K., Ohfuji Y., Shimazaki T., Meno C., Ohishi S., Matsuda Y., Fujii H., Saijoh Y. and Hamada H. (1999) GFRa3, a Component of the Artemin Receptor, Is Required for Migration and Survival of the Superior Cervical Ganglion. Neuron 23, 725-736.

  16. Meno, C., Gritsman, K., Ohishi, S., Ohfuji, Y., Heckscher, E., Mochida, K., Shimono, A., Kondoh, H., Talbot, W.S., Robertson, E.J., Schier, A.F., and Hamada, H. (1999) Mouse Lefty2 and zebrafish antivin are feedback inhibitors of nodal signaling during vertebrate gastrulation. Mol. Cell 4, 287-298.

  17. Yashiro, K., Saijoh, Y., Sakuma, R., Tada, M., Tomita, N., Amano, K., Matsuda, Y., Monden, M., Okada, S., and Hamada, H. (2000) Distinct transcriptional regulation and phylogenetic divergence of human LEFTY genes. Genes Cells 5, 343-357.

  18. Saijoh, Y., Adachi, H., Sakuma, R., Yeo, CY., Yashiro, K., Watanabe, M., Hashiguchi, H., Mochida, K., Ohishi, S., Kawabata, M., Miyazono, K., Whitman, M., and Hamada, H. (2000) Left-right asymmetric expression of lefty2 and nodal is induced by a signaling pathway that includes the transcription factor FAST2. Mol. Cell 5, 35-47.

  19. Shiratori, H., Sakuma, R., Watanabe, M., Hashiguchi, H., Mochida, K., Nishino, J., Sakai, Y., Saijoh, Y., Whitman, M., and Hamada, H. (2001) Two-step regulation of asymmetric Pitx2 expression: intiation by Nodal signaling and maintenance by Nkx2. Mol. Cell 7, 137-149.

  20. Sakai Y., Meno C., Fujii H., Nishino J., Shiratori H., Saijoh Y., Rossant J. and Hamada H. (2001) The retinoic acid inactivating enzyme CYP26 is essential for establishing an uneven distribution of retinoic acid along the anterio-posterior axis within the mouse embryo. Genes Dev. 15, 213-225.

  21. Yamamoto M., Meno C., Sakai Y., Shiratori H., Mochida K., Ikawa Y., Saijoh Y. and Hamada H. (2001) The transcription factor FoxH1 (FAST) mediates Nodal signaling during anterior-posterior patterning and node formation in the mouse. Genes Dev. 15, 1242-1256.

  22. Meno C., Takeuchi J., Sakuma R., Koshiba-Takeuchi K., Ohishi S., Saijoh Y., Miyazaki J., ten-Dijke P., Ogura T. and Hamada H. (2001) Diffusion of Nodal Signaling Activity in the Absence of the Feedback Inhibitor Lefty2. Dev. Cell 1, 127-138.

  23. Sakuma R., Ohnishi Y., Meno C., Fujii H., Juan H., Takeuchi J., Ogura T., Li E., Miyazono K. and Hamada H. (2002) Inhibition of Nodal signalling by Lefty mediated through interaction with common receptors and efficient diffusion. Genes to Cells 7, 401-412

  24. Hamada H., Meno C., Watanabe D. and Saijoh Y. (2002) Establishment of Vertebrate Left-Right Asymmetry. Nature Rev. Genetics 3, 103-113.

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