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Name |
Email |
Telephone |
| Professor |
HAMADA,Hiroshi,M.D.,D.M.Sc. |
  |
+81-6-6879-7994
|
| Assistant Prof. |
SHIRATORI,Hidetaka, D.M.Sc. |
 |
+81-6-6879-7994 |
| Assistant Prof. |
YAMAMOTO,Masamichi |
 |
+81-6-6879-7994 |
| FAX |
+81-6-6878-9846 |
| Postal Mail Address |
Developmental Genetics Droup,
Graduate School of Frontier Biosciences, Osaka University,
1-3 Yamadaoka, Suita, Osaka 565-0871 Japan |
| Fore more information |
http://www.imcb.osaka-u.ac.jp/hamada/ |
Our research is focused on regulation of
cell differentiation and morphogenesis during mammalian embryogenesis.
Following projects are currentlyin progress.
| 1 |
Determination of left-right
polarity |
| Vertebrates have numerous lateral asymmetries
such as heart and spleen on the left side. We have
recently identified a novel TGFr-related factor(lefty)
as a determinant of left-right polarity. With lefty
as a starting point, we wish to reveal the whole genetic
program regulating left-right specification and to
know how asymmetric organs such as heart are formed
at the correct position. |
| 2 |
Maintenance of pluri
(toti) potency |
| Oct-3 is a POU-domain transcription factor
expressed only in pluri (toti) potent cells, and is
implicated in maintenance of pluri (toti) potency.
By identifying the downstream genes of Oct-3 and by
analysing their function, we are investigating how
early embryonic cells and germ cells maintain pluri
(toti) potency. |
| 3 |
Differentiation and
maturation of neural cells |
| Genes regulating neurogenesis have been
searched, by using a culture cell system as a model.
Their role in neurogenesis are being studied at molecular
and cellular levels. Currently, our effort is focused
on a molecule regulating intracellular concentration
of retinoic acid, andreceptor and ligand molecules
involved in cell-cell interaction. |
| Lefty-right asymmetric location of human
organs(left) and asymmetric expression of lefty in
a mouse embryo. |
|
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| Genetic pathway determining left-right
asymmetry of vertebrate body. |
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