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Professor HAMADA,Hiroshi,M.D.,D.M.Sc. +81-6-6879-7994
Assistant Prof. SHIRATORI,Hidetaka, D.M.Sc. +81-6-6879-7994
Assistant Prof. YAMAMOTO,Masamichi +81-6-6879-7994

FAX +81-6-6878-9846
Postal Mail Address Developmental Genetics Droup, Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamadaoka, Suita, Osaka 565-0871 Japan
Fore more information http://www.imcb.osaka-u.ac.jp/hamada/

Our research is focused on regulation of cell differentiation and morphogenesis during mammalian embryogenesis. Following projects are currentlyin progress.

1 Determination of left-right polarity

Vertebrates have numerous lateral asymmetries such as heart and spleen on the left side. We have recently identified a novel TGFr-related factor(lefty) as a determinant of left-right polarity. With lefty as a starting point, we wish to reveal the whole genetic program regulating left-right specification and to know how asymmetric organs such as heart are formed at the correct position.

2 Maintenance of pluri (toti) potency

Oct-3 is a POU-domain transcription factor expressed only in pluri (toti) potent cells, and is implicated in maintenance of pluri (toti) potency. By identifying the downstream genes of Oct-3 and by analysing their function, we are investigating how early embryonic cells and germ cells maintain pluri (toti) potency.

3 Differentiation and maturation of neural cells

Genes regulating neurogenesis have been searched, by using a culture cell system as a model. Their role in neurogenesis are being studied at molecular and cellular levels. Currently, our effort is focused on a molecule regulating intracellular concentration of retinoic acid, andreceptor and ligand molecules involved in cell-cell interaction.


Lefty-right asymmetric location of human organs(left) and asymmetric expression of lefty in a mouse embryo.


Genetic pathway determining left-right asymmetry of vertebrate body.

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