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- Tsutsumi-Ishii, Y., Tadokoro,
K., Hanaoka, F., and Tsuchida, N. (1995) Response
of heat shock element within the human HSP70 promoter
to mutated p53 genes. Cell Growth Differ. 6, 1-8.
- Shiratori, A., Okumura, K., Nogami,
M., Taguchi, H., Onozaki, T., Inoue, T., Ando, T.,Shibata,
T., Izumi, M., Miyazawa, H., Hanaoka, F., Murakami,
Y., and Eki, T. (1995) Assignment of the 49-kDa (PRIM1)
and 58-kDa (PRIM2A and PRIM2B) subunit genes of the
human DNA primase to chromosome bands 1q44 and 6p11.1-p12.
Genomics 28, 350-353
- Matsuda, T., Saijo, M., Kuraoka,
I., Kobayashi, T., Nakatsu, Y., Nagai, A.,Enjoji,
T., Masutani, C., Sugasawa, K., Hanaoka, F., Yasui,
A., and Tanaka, K. (1995) DNA repair protein XPA
binds replication protein A (RPA). J. Biol. Chem.
270, 4152-4157.
- Kamiya, H., Murata-Kamiya, N.,
Fujimuro, M., Kido, K., Inoue, H., Nishimura, S.,
Masutani, C., Hanaoka, F., and Ohtsuka, E. (1995)
Comparison of incorporation and extension of nucleotides
in vitro opposite 8-hydroxyguanine (7,8-dihydro-8-oxoguanine)
in hot spots of the c-Ha-ras gene. Jpn. J. Cancer
Res. 86, 270-276.
- Matsumoto, K., Okuwaki, M., Kawase,
H., Handa, H., Hanaoka, F., and Nagata, K. (1995)
Stimulation of DNA transcription by the replication
factor from the adenovirus genome in a chromatin-like
structure. J. Biol. Chem. 270, 9645-9650.
- Sauer, F., Fondell, J. D., Ohkuma,
Y., Roeder, R. G., and Jackle, H. (1995) Control
of transcription by Kruppel through interactions
with TFIIB and TFIIE beta. Nature 375, 162-164.
- Eki, T., Hanaoka, F., Kohda, T.,
Seki, M., Ui, M., and Enomoto, T. (1995) Efficient
replication of polyomavirus DNA in a cell-free system
supplemented with Escherichia coli single-stranded
DNA binding protein, which exhibits species-specificity
in the requirement for DNA polymerase alpha-primase.
J. Biochem. (Tokyo) 118, 435-441.
- Yamaguchi, K., Kobayashi, M.,
Yamauchi, Y., Tanaka, A., Miyazawa, H., Izumi, M.,
and Hanaoka, F. (1995) Temperature-sensitive mutation
of DNA polymerase alpha induces growth-suppressive
phenotypes involving retinoblastoma protein and cyclin
D1. Cell Struct. Funct. 20, 285-291.
- Kamiya, H., Miura, H., Murata-Kamiya,
N., Ishikawa, H., Sakaguchi, T., Inoue, H., Sasaki,
T., Masutani, C., Hanaoka, F., Nishimura, S., and
Ohtsuka, E. (1995) 8-Hydroxyadenine (7,8-dihydro-8-oxoadenine)
induces misincorporation in in vitro DNA synthesis
and mutations in NIH 3T3 cells. Nucleic Acids Res.
23, 2893-2899.
- Ohkuma, Y., Hashimoto, S., Wang,
C.K., Horikoshi, M., and Roeder, R. G. (1995) Analysis
of the role of TFIIE in basal transcription and TFIIH-mediated
CTD-phosphorylation through structure-function studies
of TFIIE-alpha. Mol. Cell. Biol. 15, 4856-4866.
- Shimamoto, T., Tanimura, T., Yoneda,
Y., Kobayakawa, Y., Sugasawa, K., Hanaoka, F., Oka,
M., Okada, Y., Tanaka, K., and Kohno, K. (1995) Expression
and functional analyses of the Dxpa gene, the Drosophila
homolog of the human excision repair gene XPA. J.
Biol. Chem. 270, 22452-22459.
- Kagawa, Y., Yatagai, F., Suzuki,
M., Kase, Y., Kobayashi, A., Hirano, M., Kato, T.,
Watanabe, M., and Hanaoka, F. (1995) Analysis of
mutations in the human HPRT gene induced by accelerated
heavy-ion irradiation. J. Radiat. Res. (Tokyo) 36,
185-195.
- Tanaka, M., Sawada, M., Yoshida,
S., Hanaoka, F., and Marunouchi, T. (1995) Insulin
prevents apoptosis of external granular layer neurons
in rat cerebellar slice cultures. Neurosci. Lett.
199, 37-40.
- Taguchi, T., Ogihara, M., Maekawa,
T., Hanaoka, F., and Tanno, M. (1995) Stimulation
of DNA polymerase gamma activity by proliferating
cell nuclear antigen. Biochem. Biophys. Res. Commun.
216, 715-722.
- Hagiwara, H., Naitou, M., Shibata,
T., Hanaoka, F., Eki, T., and Murakami, Y. (1995)
Identification of the coding region of Saccharomyces
cerevisiae chromosome VI using the computer program
GenMark. DNA Res. 2, 247-253.
- Naitou, M., Ozawa, M., Sasanuma,
S., Kobayashi, M., Hagiwara, H., Shibata, T., Hanaoka,
F., Watanabe, K., Ono, A., Yamazaki, M., Tashiro,
H. Eki, T., and Murakami, Y. (1995) Sequencing of
an 18.8 kb fragment from Saccharomyces cerevisiae
chromosome VI. Yeast 11, 1525-1532.
- van der Spek, P. J., Visser, C.
E., Hanaoka, F., Smit, B., Hagemeijer, A., Bootsma,
D., and Hoeijmakers, J. H. (1996) Cloning, comparative
mapping, and RNA expression of the mouse homologues
of the Saccharomyces cerevisiae nucleotide excision
repair gene. RAD23. Genomics 31, 20-27.
- Naitou, M., Ozawa, M., Sasanuma,
S. I., Kobayashi, M., Hagiwara, H., Shibata, T.,
Hanaoka, F., Watanabe, K., Ono, A., Yamazaki, M.,
Tashiro, H., Eki, T., and Murakami, Y. (1996) Sequencing
of a 23 kb fragment from Saccharomyces cerevisiae
chromosome VI. Yeast 12, 77-84.
- Eki, T., Abe, M., Furuya, K.,
Ahmad, I., Fujishima, N., Kishida, H., Shiratori,
A., Onozaki, T., Yokoyama, K., Le Paslier, D., Cohen,
D., Hanaoka, F., and Murakami, Y. (1996) A long-range
physical map of human chromosome 21q22.1 band from
the YAC continuum. Mamm. Genome. 7, 303-311.
- Kawakami, K., Masuda, K., Nagano,
K., Ohkuma, Y., and Roeder, R. G. (1996) Characterization
of the core promoter of Na, K-ATPase a1 subunit gene:
Elements required for transcription by RNA polymerase
II and III in vitro. Eur. J. Biochem. 237, 440-446.
- Eki, T., Naitou, M., Hagiwara,
H., Abe, M., Ozawa, M., Sasanuma, S., Sasanuma, M.,
Tsuchiya, Y., Shibata, T., Watanabe, K., Ono, A.,
Yamazaki, M., Tashiro, H., Hanaoka, F., and Murakami,
Y. (1996) Fifteen open reading frames in a 30.8 kb
region of the right arm of chromosome VI from Saccharomyces
cerevisiae. Yeast 12, 177-190.
- van der Spek, P. J., Eker, A.,
Rademakers, S., Visser, C., Sugasawa, K., Masutani,
C., Hanaoka, F., Bootsma, D., and Hoeijmakers, J.
H. (1996) XPC and human homologs of RAD23: intracellular
localization and relationship to other nucleotide
excision repair complexes. Nucleic Acids Res. 24,
2551-2559.
- Ennas, M. G., Suzuki, H., Menegazzi,
M., Carcereri, A., Hanaoka, F., Gremo, F., Nieddu,
M., and Mezzanotte, R. (1996) On the presence of
DNA polymerase alpha in human lymphocyte nuclei and
chromosomes. Heredity 77, 186-191.
- Sugasawa, K., Masutani, C., Uchida,
A., Maekawa, T., van der Spek, P. J., Bootsma, D.,
Hoeijmakers, J. H., and Hanaoka, F. (1996) HHR23B,
a human Rad23 homolog, stimulates XPC protein in
nucleotide excision repair in vitro. Mol Cell Biol
16, 4852-4861.
- Eki, T., Okumura, K., Amin, A.,
Ishiai, M., Abe, M., Nogami, M., Taguchi, H., Hurwitz,
J., Murakami, Y., and Hanaoka, F. (1996) Mapping
of the human homologue (ORC1L) of the yeast origin
recognition complex subunit 1 gene to chromosome
band 1p32. Genomics 36, 559-561.
- Ito, K., Asano, M., Hughes, P.,
Kohzaki, H., Masutani, C., Hanaoka, F., Kerppola,
T., Curran, T., Murakami, Y., and Ito, Y. (1996)
c-Jun stimulates origin-dependent DNA unwinding by
polyomavirus large T antigen. EMBO J. 15, 5636-5646.
- Mizuno, T., Okamoto, T., Yokoi,
M., Izumi, M., Kobayashi, A., Hachiya, T., Tamai,
K., Inoue, T., and Hanaoka, F. (1996) Identification
of the nuclear localization signal of mouse DNA primase:
nuclear transport of p46 subunit is facilitated by
interaction with p54 subunit. J. Cell Sci. 109, 2627-2636.
- Eki, T., Okumura, K., Shiratori,
A., Abe, M., Nogami, M., Taguchi, H., Shibata, T.,
Murakami, Y., and Hanaoka, F. (1996) Assignment of
the closest human homologue (DNA2L:KIAA0083) of the
yeast Dna2 helicase gene to chromosome band 10q21.3-q22.1.
Genomics 37, 408-410.
- Saijo, M., Kuraoka, I., Masutani,
C., Hanaoka, F., and Tanaka, K. (1996) Sequential
binding of DNA repair proteins RPA and ERCC1 to XPA
in vitro. Nucleic Acids Res. 24, 4719-4724.
- Fujiwara, Y., Masutani, C., Hanaoka,
F., and Iwai, S. (1997) Detection, purification and
characterization of a protein that binds the (6-4)
photoproduct-containing DNA in HeLa cells. Nucleic
Acids Symp Ser 37, 277-278.
- Mahamed, M. M., Matsukage, A.,
Date, T., Hanaoka, F., and Yatagai, F. (1997) In
vitro DNA synthesis error specificity: A single amino-acid
replacement in rat DNA polymerase beta. Environ.
Mutagen Res. 19, 7-15.
- Osada, H., Cui, C. B., Onose,
R., and Hanaoka, F. (1997) Screening of cell cycle
inhibitors from microbial metabolites by a bioassay
using a mouse cdc2 mutant cell line, tsFT210. Bioorg.
Med. Chem. 5, 193-203.
- Kojima, S., Kobayashi, A., Gotoh,
O., Ohkuma, Y., Fujii-Kuriyama, Y., and Sogawa, K.
(1997) Transcriptional activation domain of human
BTEB2, a GC box-binding factor. J. Biochem. (Tokyo)
121, 389-396.
- Lapenta, V., Chiurazzi, P., van
der Spek, P., Pizzuti, A., Hanaoka, F., and Brahe,
C. (1997) SMT3A, a human homologue of the S. cerevisiae
SMT3 gene, maps to chromosome 21qter and defines
a novel gene family. Genomics 40, 362-366.
- Ikehata, H., Kaneda, S., Yamao,
F., Seno, T., Ono, T., and Hanaoka, F. (1997) Incubation
at the nonpermissive temperature induces deficiencies
in UV resistance and mutagenesis in mouse mutant
cells expressing a temperature-sensitive ubiquitin-activating
enzyme (E1). Mol. Cell. Biol. 17, 1484-1489.
- Eki, T., Abe, M., Naitou, M.,
Sasanuma, S. I., Nohata, J., Kawashima, K., Ahmad,
I., Hanaoka, F., and Murakami, Y. (1997) Cloning
and characterization of novel gene, DCRR1, expressed
from Down's syndrome critical region of human chromosome
21q22.2. DNA Seq. 7, 153-164.
- Ohkuma, Y. (1997) Multiple functions
of general transcription factors TFIIE and TFIIH
in transcription: Possible points of regulation by
trans-acting factors. (JB Review) J. Biochem. (Tokyo)
122, 481-489.
- Naitou, M., Hagiwara, H., Hanaoka,
F., Eki, T., and Murakami, Y. (1997) Expression profiles
of transcripts from 126 open reading frames in the
entire chromosome VI of Saccharomyces cerevisiae
by systematic northern analyses.Yeast 13, 1275-1290.
- Yokoi, M., Ito, M., Izumi, M.,
Miyazawa, H., Nakai, H., and Hanaoka, F. (1997) Molecular
cloning of the cDNA for the catalytic subunit of
plant DNA polymerase alpha and its cell-cycle dependent
expression. Genes Cells 2, 695-709.
- Sasaki, H., Yatagai, F., Kanai,
T., Furusawa, Y., Hanaoka, F., Zhu, W. G., and Mehnati,
P. (1997) Dependence of induction of interphase death
of Chinese hamster ovary cells exposed to accelerated
heavy ions on linear energy transfer. Radiat. Res.
148, 449-454.
- Masutani, C., Araki, M., Sugasawa,
K., van der Spek, P. J., Yamada, A., Uchida, A.,
Maekawa, T., Bootsma, D., Hoeijmakers, J. H., and
Hanaoka, F. (1997) Identification and characterization
of XPC-binding domain of hHR23B. Mol. Cell. Biol.
17, 6915-6923.
- Sugasawa, K., Ng, J. M., Masutani,
C., Maekawa, T., Uchida, A., van der Spek, P. J.,
Eker, A. P., Rademakers, S., Visser, C., Aboussekhra,
A., Wood, R. D., Hanaoka, F., Bootsma, D., and Hoeijmakers,
J. H. (1997) Two human homologs of Rad23 are functionally
interchangeable in complex formation and stimulation
of XPC repair activity. Mol. Cell. Biol. 17, 6924-6931.
- Withers-Ward, E. S., Jowett,
J. B., Stewart, S. A., Xie, Y. M., Garfinkel, A.,
Shibagaki, Y., Chow, S. A., Shah, N., Hanaoka, F.,
Sawitz, D. G., Armstrong, R. W., Souza, L. M., and
Chen, I. S. (1997) Human immunodeficiency virus type
1 Vpr interacts with HHR23A, a cellular protein implicated
in nucleotide excision DNA repair. J. Virol. 71,
9732-9742.
- Ishiai, M., Dean, F. B., Okumura,
K., Abe, M., Moon, K. Y., Amin, A. A., Kagotani,
K., Taguchi, H., Murakami, Y., Hanaoka, F., O'Donnell,
M., Hurwitz, J., and Eki, T. (1997) Isolation of
human and fission yeast homologues of the budding
yeast origin recognition complex subunit ORC5: human
homologue (ORC5L) maps to 7q22. Genomics 46, 294-298.
- Sakamoto, A., Ono, K., Abe, M.,
Jasmin, G., Eki, T., Murakami, Y., Masaki, T., Toyo-oka,
T., and Hanaoka, F. (1997) Both hypertrophic and
dilated cardiomyopathies are caused by mutation of
the same gene, delta-sarcoglycan, in hamster: an
animal model of disrupted dystrophin-associated glycoprotein
complex. Proc. Natl. Acad. Sci. USA 94, 13873-13878.
- Kimura, M., Matsuda, Y., Eki,
T., Yoshioka, T., Okumura, K., Hanaoka, F., and Okano,
Y. (1997) Assignment of STK6 to human chromosome
20q13.2-->q13.3 and a pseudogene STK6P to 1q41-->q42.
Cytogenet. Cell Genet. 79, 201-203.
- Eki, T., Okumura, K., Abe, M.,
Kagotani, K., Taguchi, H., Murakami, Y., Pan, Z.
Q., and Hanaoka, F. (1998) Mapping of the human genes
encoding cyclin H (CCNH) and the CDK-activating kinase
(CAK) assembly factor MAT1 (MNAT1) to chromosome
bands 5q13.3-q14 and 14q23, respectively. Genomics
47, 115-120.
- Yamauchi, Y., Tanaka, A., Yamaguchi,
K., Kobayashi, M., Shimamura, S., and Hanaoka, F.
(1998) Apoptosis was promoted at a nonpermissive
temperature in DNA replication-defective temperature-sensitive
mutants of mouse FM3A cells. Exp. Cell. Res. 238,
317-323.
- Yamauchi, Y., Tanaka, A., Hanaoka,
F., and Okumura, K. (1998) A mutant strain of mouse
FM3A cells defective in apoptotic DNA fragmentation.
Biochem. Biophys. Res. Commun. 243, 550-554.
- Carrier, F., Zhan, Q., Alamo,
I., Hanaoka, F., and Fornace, A. J., Jr. (1998) Evidence
for distinct kinase-mediated pathways in gadd gene
responses. Biochem. Pharmacol. 55, 853-861.
- Eki, T., Dean, F. B., Kohda, A.,
Okumura, K., Abe, M., Murakami, Y., Ishiai, M., Satomoto,
K., Hurwitz, J., O'Donnell, M., and Hanaoka, F. (1998)
Assignment of the homologue of the yeast origin recognition
complex subunit ORC4 (ORC4L) to human chromosome
band 2q22-->q23 by in situ hybridization and somatic
cell hybrid analysis. Cytogenet. Cell. Genet. 81,
89-90.
- Kai, M., Todo, T., Wada, M.,
Ryo, H., Masutani, C., Kobayashi, H., Morioka, H.,
Ohtsuka, E., Hanaoka, F., and Sakaguchi, K. (1998)
A new Drosophila ultraviolet light-damaged DNA recognition
endonuclease that selectively nicks a (6-4) photoproduct
site. Biochim. Biophys. Acta. 1397, 180-188.
- Chino, M., Nishikawa, K., Yamada,
A., Ohsono, M., Sawa, T., Hanaoka, F., Ishizuka,
M., and Takeuchi, T. (1998) Effect of a novel antibiotic,
heliquinomycin, on DNA helicase and cell growth.
J. Antibiot. (Tokyo) 51, 480-486.
- Mizuno, T., Ito, N., Yokoi, M.,
Kobayashi, A., Tamai, K., Miyazawa, H., and Hanaoka,
F. (1998) The second-largest subunit of the mouse
DNA polymerase alpha-primase complex facilitates
both production and nuclear translocation of the
catalytic subunit of DNA polymerase a. Mol. Cell.
Biol. 18, 3552-3562.
- Fujita, M., Yamada, C., Tsurumi,
T., Hanaoka, F., Matsuzawa, K., and Inagaki, M. (1998)
Cell cycle- and chromatin binding state-dependent
phosphorylation of human MCM heterohexameric complexes.
A role for cdc2 kinase. J. Biol. Chem. 273, 17095-17101.
- Okamoto, T., Yamamoto, S., Watanabe,
Y., Ohta, T., Hanaoka, F., Roeder, R. G., and Ohkuma,
Y. (1998) Analysis of the role of TFIIE in transcriptional
regulation through structure-function studies of
the TFIIE beta subunit. J. Biol. Chem. 273, 19866-19876.
- Sugasawa, K., Ng, J. M., Masutani,
C., Iwai, S., van der Spek, P. J., Eker, A. P., Hanaoka,
F., Bootsma, D., and Hoeijmakers, J. H. (1998) Xeroderma
pigmentosum group C protein complex is the initiator
of global genome nucleotide excision repair. Mol.
Cell 2, 223-232.
- Hoshino, S., Imai, M., Mizutani,
M., Kikuchi, Y., Hanaoka, F., Ui, M., and Katada,
T. (1998) Molecular cloning of a novel member of
the eukaryotic polypeptide chain-releasing factors
(eRF). Its identification as eRF3 interacting with
eRF1. J. Biol. Chem. 273, 22254-22259.
- Ohtaka-Maruyama, C., Hanaoka,
F., and Chepelinsky, A. B. (1998) A novel alternative
spliced variant of the transcription factor AP2 alpha
is expressed in the murine ocular lens. Dev. Biol.
202, 125-135.
- Lee, C.-G., Eki, T., Okumura,
K., Nogami, M., da Costa Soares, V., Murakami, Y.,
Hanaoka, F., and Hurwitz, J. (1999, Jan) The human
RNA helicase A (DDX9) gene maps to the prostate cancer
susceptibility locus at chromosome band 1q25 and
its pseudogene (DDX9P) to 13q22, respectively. Somat.
Cell Mol. Genet. 25, 33-39.
- Shiratori, A., Shibata, T., Arisawa,
M., Hanaoka, F., Murakami, Y., and Eki, T. (1999)
Systematic identification, classification, and characterization
of the open reading frames which encode novel helicase-related
proteins in Saccharomyces cerevisiae by gene disruption
and Northern analysis. Yeast 15, 219-253.
- Kagawa, Y., Shimazu, T., Gordon,
A. J. E., Fukunishi, N., Inabe, N., Suzuki, M., Hirano,
M., Kato, T., Watanabe, M., Hanaoka, F., and Yatagai,
F. (1999) Complex hprt deletion events are recovered
after exposure of human lymphoid cells to high-LET
carbon and neon ion beams. Mutagenesis 14, 199-205.
- Shimada, M., Konishi, Y., Ohkawa,
N., Ohtaka-Maruyama, C., Hanaoka, F., Makino, Y.,
and Tamura, T. (1999) Distribution of AP-2 subtypes
in the adult brain. Neuroscience. Res. 33, 275-280.
- Iwai, S., Mizukoshi, T., Fujiwara,
Y., Masutani, C., Hanaoka, F., and Hayakawa, Y. (1999)
Benzimidazolium triflate-activated synthesis of (6-4)
photoproduct-containing oligonucleotides and its
application. Nucleic Acids Res. 27, 2299-2303.
- Masutani, C., Araki, M., Yamada,
A., Kusumoto, R., Nogimori, T., Maekawa, T., Iwai,
S., and Hanaoka, F. (1999) Xeroderma pigmentosum
variant (XP-V) correcting protein from HeLa cells
has a thymine dimer bypass DNA polymerase activity.
EMBO J. 18, 3491-3501.
- Masutani, C., Kusumoto, R., Yamada,
A., Dohmae, N., Yokoi, M., Yuasa, M., Araki, M.,
Iwai, S., Takio, K., and Hanaoka, F. (1999) The XPV
(xeroderma pigmentosum variant) gene encodes human
DNA polymerase eta. Nature 399, 700-704.
- Sato, M., Ura, K., Hohmura, K.,
Tokumasu, F., Yoshimura, S. H., Hanaoka, F., and
Takeyasu, K. (1999) Atomic force microscopy sees
nucleosome positioning and histone H1-induced compaction
in reconstituted chromatin. FEBS Lett. 452, 267-271.
- Fujiwara, Y., Masutani, C., Mizukoshi,
T., Kondo, J., Hanaoka, F., and Iwai, S. (1999) Characterization
of DNA recognition by the human UV-damaged-DNA binding
protein. J. Biol. Chem. 274, 20027-20033.
- Hiyama, H., Yokoi, M., Masutani,
C., Sugasawa, K., Maekawa, T., Tanaka, K., Hoeijmakers,
J. H. J., and Hanaoka, F. (1999) Interaction of hHR23
with S5a: The ubiquitin-like domain of hHR23 mediates
interaction with S5a subunit of 26S proteasome. J.
Biol. Chem. 274, 28019-28025.
- Mizuno, T., Yamagishi, K., Miyazawa,
H., and Hanaoka, F. (1999) Molecular architecture
of the mouse DNA polymerase alpha?primase complex.
Mol. Cell. Biol. 19, 7886-7896.
- Araki, M., Masutani, C., Maekawa,
T., Watanabe, Y., Yamada, A., Kusumoto, R., Sakai,
D., Sugasawa, K., Ohkuma, Y., and Hanaoka, F. (2000)
Reconstitution of damage DNA excision reaction from
SV40 minichromosomes with purified nucleotide excision
repair proteins. Mutat. Res. 459, 147-160.
- Okuda, M., Watanabe, Y., Okamura,
H., Hanaoka, F., Ohkuma, Y., and Nishimura, Y. (2000)
Structure of the central core domain of TFIIEb with
a novel double-stranded DNA-binding surface. EMBO
J. 19, 1346-1356.
- Yokoi, M., Masutani, C., Maekawa,
T., Sugasawa, K., Ohkuma, Y., and Hanaoka, F. (2000)
The xeroderma pigmentosum group C protein complex
XPC-HR23B plays an important role in the recruitment
of transcription factor IIH to damaged DNA. J. Biol.
Chem. 275, 9870-9875.
- Nishikawa, N. S., Izumi, M., Uchida,
H., Yokoi, M., Miyazawa, H., and Hanaoka, F. (2000)
Cloning and characterization of the 5'-upstream sequence
governing the cell cycle-dependent transcription
of mouse DNA polymerase alpha-p 68-kDa subunit gene.
Nucleic Acids Res. 28, 1525-1534.
- Vaisman, A., Masutani, C., Hanaoka,
F., and Chaney, S. G. (2000) Efficient translesion
replication past oxaliplatin and cisplatin GpG adducts
by human DNA polymerase eta. Biochemistry 39, 4575-4580.
- Matsuda, T., Bebenek, K., Masutani,
C., Hanaoka, F., and Kunkel, T. A. (2000) Low fidelity
DNA synthesis by human DNA polymerase eta. Nature
404, 1011-1013.
- Watanabe, Y., Fujimoto, H., Watanabe,
T., Maekawa, T., Masutani, C., Hanaoka, F., and Ohkuma,
Y. (2000) Modulation of TFIIH-associated kinase activity
by complex formation and its relationship with CTD
phosphorylation of RNA polymerase II. Genes Cells
5, 407-423.
- Masutani, C., Kusumoto, R., Iwai,
S., and Hanaoka, F. (2000) Mechanisms of accurate
translesion synthesis by human DNA polymerase eta.
EMBO J. 19, 3100-3109.
- Yamada, A., Masutani, C., Iwai,
S., and Hanaoka, F. (2000) Complementation of defective
translesion synthesis and ultraviolet light sensitivity
in xeroderma pigmentosum variant cells by human and
mouse DNA polymerase eta. Nucleic Acids Res. 28,
2473-2480.
- Ohashi, E., Ogi, T., Kusumoto,
R., Iwai, S., Masutani, C., Hanaoka, F., and Ohmori,
H. (2000) Error-prone bypass of certain DNA lesions
by the human DNA polymerase kappa. Genes Dev. 14,
1589-1594.
- Izumi, M., Yokoi, M., Nishikawa,
N., Miyazawa, H., Sugino, A., Yamagishi, M., Yamaguchi,
M., Matsukage, A., Yatagai, F., and Hanaoka, F. (2000)
Transcription of the catalytic 180-kDa subunit gene
of mouse DNA polymerase alpha is controlled by E2F,
an Ets-related transcription factor, and Sp1. Biochim.
Biophys. Acta 1492, 341-352.
- Miao, F., Bouziane, M., Dammann,
R., Masutani, C., Hanaoka, F., Pfeifer, G. P., and
O'Connor, T. R. (2000) 3-methyladenine-DNA glycosylase
(MPG protein) interacts with huamn RAD23 proteins.
J. Biol. Chem. 275, 28433-28438.
- Yuasa, M., Masutani, C., Eki,
T., and Hanaoka, F. (2000) Genomic structure, chromosomal
localization and identification of mutations in the
xeroderma pigmentosum variant (XPV) gene. Oncogene,
19, 4721-4728.
- Tissier, A., Frank, E. G., McDonald,
J. P., Iwai, S., Hanaoka, F., and Woodgate, R. (2000)
Misinsertion and bypass of thymine-thymine dimers
by human DNA polymerase iota. EMBO J. 19, 5259-5266.
- Mizushina, Y., Kamisuki, S., Mizuno,
T., Takemura, M., Asahara, H., Linn, S., Yamaguchi,
M., Matsukage, A., Hanaoka, F., Yoshida, S., Saneyoshi,
M., Sugawara, F., and Sakaguchi, K. (2000) Dehydroaltenusin:
A mammalian DNA polymerase alpha inhibitor. J. Biol.
Chem. 275, 33957-33961.
- Douziech, M., Coin, F., Chipoulet,
J.-M., Arai, Y., Ohkuma, Y., Egly, J.-M. and Coulombe,
B. (2000) Mechanism of promoter melting by the Xeroderma
pigmentosum complementation group B helicase of transcription
factor IIH revealed by protein-DNA photo-cross-linking.
Mol. Cell. Biol. 20, 8168-8177.
- Izumi, M., Yanagi, K., Mizuno,
T., Yokoi, M., Kawasaki, Y., Moon, K.-Y., Hurwitz,
J., Yatagai, F., and Hanaoka, F. (2000) The human
homolog of Saccharomyces cerevisiae Mcm10 interacts
with replication factors and dissociates from nuclease-resistant
nuclear structures in G2 phase. Nucleic Acids Res.
28, 4769-4777.
- Masutani, C., Kusumoto, R., Yamada,
A., Yuasa, M., Araki, M., Nogimori, T., Yokoi, M.,
Eki, T., Iwai, S., and Hanaoka, F. (2000) Xeroderma
pigmentosum variant: From a human genetic disorder
to a novel DNA polymerase. Cold Spring Harbor Symp.
Quant. Biol. 65, 71-80.
- Hanaoka, F. (2001) SOS polymerases.
Nature 409, 33-34.
- Yamamoto, S., Watanabe, Y., van
der Spek, P., Watanabe, T., Fujimoto, H., Hanaoka,
F., and Ohkuma, Y. (2001) Studies of nematode TFIIE
function reveal a link between Ser-5 phosphorylation
of RNA polymerase II and the transition from transcription
initiation to elongation. Mol. Cell. Biol. 21, 1-15.
- Kannouche, P., Broughton, B. C.,
Volker, M., Hanaoka, F., Mullenders, L. H. F., and
Lehmann, A. R. (2001) Domain structure, localization
and function of DNA polymerase eta, defective in
xeroderma pigmentosum variant cells. Genes Dev. 15,
158-172.
- Nishikawa, N. S., Izumi, M., Yokoi,
M., Miyazawa, H., and Hanaoka, F. (2001) E2F regulates
growth-dependent transcription of genes encoding
both catalytic and regulatory subunits of mouse primase.
Genes Cells 6, 57-70.
- McDonald, J. P., Tissier, A.,
Frank, E. G., Iwai, S., Hanaoka, F., and Woodgate,
R. (2001) DNA polymerase iota and related rad30-like
enzymes. Philos. Trans. R. Soc. Lond. B. Biol. Sci.
356, 53-60.
- Bebenek, K., Matsuda, T., Masutani,
C., Hanaoka, F., and Kunkel, T. A. (2001) Proofreading
of DNA polymerase eta-dependent replication errors.
J. Biol. Chem. 276, 2317-2320.
- Sugasawa, K., Okamoto, T., Shimizu,
Y., Masutani, C., Iwai, S., and Hanaoka, F. (2001)
Multi-step recognition mechanism in the global genomic
nucleotide excision repair. Genes Dev. 15, 507-521.
- Mehnali, P., Yatagai, F., Tsuzuki,
T., Hanaoka, F., and Sasaki, H. (2001) Judgement
on “hit or non-hit” of CHO cells exposed to accelerated
heavy-ions (Fe- or Ar-ions) using division delay
and CR-39 plastics as an indicator. Fukuoka Igaku
Zasshi 92, 46-57.
- Kusumoto, R., Masutani, C., Sugasawa,
K., Iwai, S., Araki, M., Uchida, A., Mizukoshi, T.,
and Hanaoka, F. (2001) Diversity of the damage recognition
step in the global genomic nucleotide excision repair
in vitro. Mutation Res. 485, 219-227.
- Ura, K., Araki, M., Saeki, H.,
Masutani, C., Ito, T., Iwai, S., Mizukoshi, T., Kaneda,
Y., and Hanaoka, F. (2001) ATP-dependent chromatin
remodeling facilitates nucleotide excision repair
of UV-induced DNA lesions in synthetic dinucleosomes.
EMBO J. 20, 2004-2014.
- Ishikawa, T., Uematsu, N., Mizukoshi,
T., Iwai, S., Iwasaki, H., Masutani, C., Hanaoka,
F., Ueda, R., Ohmori, H., and Todo, T. (2001) Mutagenic
and non-mutagenic bypass of DNA lesions by Drosophila
DNA polymerases dpolh and dpoli. J. Biol. Chem. 276,
15155-15163.
- Araki, M., Masutani, C., Takemura,
M., Uchida, A., Sugasawa, K., Kondoh, J., Ohkuma,
Y., and Hanaoka, F. (2001) Centrosome protein centrin2/caltractin1
is part of the xeroderma pigmentosum group C complex
that initiates global genome nucleotide excision
repair. J. Biol. Chem. 276, 18665-18672.
- Levine, R. L., Miller, H., Grollman,
A., Ohashi, E., Ohmori, H., Masutani, C., Hanaoka,
F., and Moriya, M. (2001) Translesion DNA synthesis
catalyzed by human pol eta and pol kappa across 1,N6-ethenodeoxyadenosine.
J. Biol. Chem. 276, 18717-18721.
- Ohmori, H., Friedberg, E. C.,
Fuchs, R. P. P., Goodman, M. F., Hanaoka, F., Hinkle,
D., Kunkel, T. A., Lawrence, C. W., Livneh, Z., Nohmi,
T., Prakash, L., Prakash, S., Todo, T., Walker, G.
C., Wang, Z., and Woodgate, R. (2001) The Y-family
of DNA polymerases. Mol. Cell 8, 7-8.
- Matsuda, T., Bebenek, K., Masutani,
C., Rogozin, I. B., Hanaoka. F., and Kunkel, T. A.
(2001) Error rate and specificity of human and murine
DNA polymerase eta. J. Mol. Biol. 312, 335-346.
- Katsumi, S., Kobayashi, N., Imoto,
K., Nakagawa, A., Yamashina, Y., Muramatsu, T., Shirai,
T., Miyagawa, S., Sugiura, S., Hanaoka, F., Matsunaga,
T., Nikaido, O., and Mori, T. (2001) In situ visualization
of ultraviolet-light-induced DNA damage repair in
locally irradiated human fibroblasts. J. Invest.
Dermatol. 117, 1156-1161.
- Boudsocq, F., Iwai, S., Hanaoka,
F., and Woodgate, R. (2001) Sulfolobus solfataricus
P2 DNA polymerase IV (Dpo4): an archaeal DinB-like
DNA polymerase with lesion-bypass properties akin
to eukaryotic pol eta. Nucleic Acids Res. 29, 4607-4616.
- Burgers, P. M., Koonin, E. V.,
Bruford, E., Blanco, L., Burtis, K. C., Christman,
M. F., Copeland, W. C., Friedberg, E. C., Hanaoka,
F., Hinkle, D. C., Lawrence, C. W., Nakanishi, M.,
Ohmori, H., Prakash, L., Prakash, S., Reynaud, C.
A., Sugino, A., Todo, T., Wang, Z., Weill, J. C.,
and Woodgate, R. (2001) Eukaryotic DNA polymerases:
proposal for a revised nomenclature. J. Biol. Chem.
276, 43487-43490.
- Izumi, M., Yatagai, F., and Hanaoka,
F. (2001) Cell cycle-dependent proteolysis and phosphorylation
of human Mcm10. J. Biol. Chem. 276, 48526-48531.
- Ito, N., Nureki, O., Shirouzu,
M., Yokoyama, S., and Hanaoka, F. (2001) Crystallization
and preliminary X-ray analysis of a DNA primase from
the hyperthermophilic archaeon, Pyrococcus horikoshii.
J. Biochem. (Tokyo) 130, 727-730.
- Kuraoka, I., Robins, P., Masutani,
C., Hanaoka, F., Gasparutto, D., Cadet, J., Wood,
R. D., and Lindahl, T. (2001) Oxygen free-radical
damage to DNA: translesion synthesis by DNA polymerase
eta and resistance to exonuclease action at cyclopurine
deoxynucleoside residues. J. Biol. Chem. 276, 49283-49288.
- Yatagai, F., Nohmi, T., Kusakabe,
M., Masumura, K., Yoshiki, A., Yamaguchi, H., Kurobe,
T., Kuniya, K., Hanaoka, F., and Yano, Y. (2001)
Mutation induction by heavy-ion irradiation of gpt
delta transgenic mice. Phys. Med. 17, 192-193.
- Sugasawa, K., Shimizu, Y., Iwai,
S., and Hanaoka, F. (2002) A molecular mechanism
for DNA damage recognition by the xeroderma pigmentosum
group C protein complex. DNA Repair 1, 95-107.
- Broughton, B. C., Cordonier, A.,
Kleijer, W. J., Jaspers, N. G., Fawcett, H., Raams,
A., Garritsen, V. H., Stary, A., Avril, M. F., Boudsocq,
F., Masutani, C., Hanaoka, F., Fuchs, R. P., Sarasin,
A., and Lehmann, A. R. (2002) Molecular analysis
of mutations in DNA polymerase eta in xeroderma pigmentosum-variant
patients. Proc. Natl. Acad. Sci. USA 99, 815-820.
- Ng, J. M., Vrieling, H., Sugasawa,
K., Ooms, M. P.,. Grootegoed, J. A., Vreeburg, J.
T. M., Visser, P., Beems, R. B., Gorgels, T. G. M.
F., Hanaoka, F., Hoeijmakers, J. H. J., and van der
Horst, G. T. J. (2002) Developmental defects and
male sterility in mice lacking the ubiquitin-like
DNA repair gene mHR23B. Mol. Cell. Biol. 22, 1233-1245.
- Nakanishi, A., Imajoh-Ohmi, S.,
and Hanaoka, F. (2002) Characterization of the interaction
between GyrI (DNA gyrase inhibitor) and DNA gyrase
of Escherichia coli. J. Biol. Chem. 277, 8949-8954.
- Wada, M., Miyazawa, H., Wang,
R.-S.,Mizuno, T., Sato, A., Asashima, M., and Hanaoka,
F. (2002) The second subunit of mouse DNA polymerase
epsilon, DPE2, interacts with SAP18 and recruits
the Sin3 Co-repressor protein to DNA. J. Biochem.
(Tokyo) 131, 307-311.
- Chiapperino, D., Kroth, H., Kramarczuk,
I., Sayer, J. M., Masutani, C., Hanaoka, F., Jerina,
D. M., and Cheh, A. M. (2002, Apr) Preferential misincorporation
of purine nucleotides by human DNA polymerase eta
opposite benzo[a]pyrene 7,8-diol 9,10-epoxide deoxyguanosine
adducts. J. Biol. Chem. 277, 11765-11771.
- Ahmad, S. I., Hanaoka, F., and
Kirk, S. H. (2002) Molecular biology of Fanconi anaemia
? an old problem, a new insight. BioEssays 24, 439-448.
- Morimoto, S., Kato, T., Honma,
M., Hayashi, M., Hanaoka, F., and Yatagai, F. (2002)
Detection of genetic alterations induced by low-dose
X rays: analysis of loss of heterozygosity for TK
mutation in human lymphoblastoid cells. Radiat. Res.
157, 533-538.
- Kusumoto, R., Masutani, C., Iwai,
S., and Hanaoka, F. (2002) Translesion synthesis
by human DNA polymerase eta across thymins glycol
lesions. Biochemistry, 41, 6090-6099.
- Hey, T., Lipps, G., Sugasawa,
K., Iwai, S., Hanaoka, F., and Krauss, G. (2002)
The XPC-HR23B complex displays high addinity and
specificity for damaged DNA in a true-equilibrium
fluorescence assay. Biochemistry, 41, 6583-6587.
- Uchida, A., Sugasawa, K., Masutani,
C., Dohmae, N., Araki, M., Yokoi, M., Ohkuma, Y.,
and Hanaoka, F. (2002) The carboxy-terminal domain
of the XPC protein plays a crucial role in nucleotide
excision repair through interactions with transcription
factor IIH. DNA Repair, 1, 449-461.
- Pavlov, Y. I., Rogozin, I. B.,
Galkin, A. P., Aksenova, A. Y., Hanaoka, F., Rada,
C., and Kunkel, T. A. (2002) Correlation of somatic
hypermuqtation specificity and A-T base pair substitution
errors by DNA polymerase eta during copying of a
mouse immunoglobulin kappa light chain transgene.
Proc. Natl. Acad. Sci. USA, 99, 9954-9959.
- Fukumoto, Y., Hiyama, H., Yokoi,
M., Nakaseko, Y., Yanagida, M., and Hanaoka, F. (2002)
Two budding yeast RAD4 homologs in fission yeast
play different roles in the repair of UV-induced
DNA damage. DNA Repair, 10, 855-868.
- Yamada, A., Masutani, C., and
Hanaoka, F. (2002) Detection of reduced RNA synthesis
in UV-irradiated Cockayne syndrome group B cells
using an isolated nuclear system. Biochim. Biophys.
Acta, 1592, 129-134.
- Yanagi, K., Mizuno, T., You, Z.,
and Hanaoka, F. (2002) Mouse geminin inhibits not
only Cdt1-MCM6 interactions but also a novel intrinsic
Cdt1 DNA binding activity. J. Biol. Chem. 277, 40871-40880.
- You, Z., Ishimi, Y., Masai, H.,
and Hanaoka, F. (2002) Roles of Mcm7 and Mcm4 subunits
in DNA helicase activity of mouse Mcm4/6/7 complex.
J. Biol. Chem. 277, 42471-42479.
- Servant, L., Cazaux, C., Bieth,
A., Iwai, S., Hanaoka, F., and Hoffmann, J. S. (2002)
A role for DNA polymerase beta?in mutagenic UV lesions
bypass. J. Biol. Chem. 277, 50046-50053.
- Bassett, E., Vaisman, A., Tropea,
K. A., McCall, C. M., Masutani, C., Hanaoka, F.,
and Chaney, S. G. (2002) Frameshifts and deletions
during in vitro translesion synthesis past Pt-DNA
adducts by DNA polymerases beta and eta. DNA Repair
1, 1003-1016.
- Shimizu, Y., Iwai, S., Hanaoka,
F., and Sugasawa, K. (2003) Xeroderma pigmentosum
group C protein interacts physically and functionally
with thymine DNA glycosylase. EMBO J. 22, 164-173.
- Janicievic, A., Sugasawa, K.,
Shimizu, Y., Hanaoka, F., Wijgers, N., Djurica, M.,
Hoeijmakers, J. H. J., and Wyman, C. (2003) DNA bending
by the human damage recognition complex XPC-HR23B.
DNA Repair 2, 325-336.
- Shimizu, M., Gruz, P., Kamiya,
H., Kim, S.-R., Pisani, F. M., Masutani, C., Kanke,
Y., Harashima, H., Hanaoka, F., and Nohmi, T. (2003)
Erroneous incorporation of oxidized DNA precursors
by Y-family DNA polymerases. EMBO Rep. 4, 269-273.
- Watanabe, T., Hayashi, K., Tanaka,
A., Furumoto, T., Hanaoka, F., and Ohkuma, Y. (2003)
The carboxy terminus of the small subunit of TFIIE
regulates the transition from transcription initiation
to elongation by RNA polymerase II. Mol. Cell. Biol.
23, 2914-2926.
- Yang, I. Y., Miller, H., Wang,
Z., Frank, E. G., Ohmori, H., Hanaoka, F., and Moriya,
M. (2003) Mammalian translesion DNA synthesis across
an acrolen-derived deoxyguanosine adduct: Participation
of DNA polymerase eta in error-prone synthesis in
human cells. J. Biol. Chem. 278, 13989-13994.
- Friedberg, E. C., Hanaoka, F.,
Tanaka, K., Wilson, S. H., and Yasui, A. (2003) Report
on the First US-Japan DNA Repair Meeting. Sendai,
Japan, October 27-31, 2002. DNA Repair 2, 639-652.
- Kamada, K., Hanaoka, F., and Burley,
S. K. (2003) Crystal structure of the MazE/MazF complex.
Molecular bases of antidote-toxin recognition. Mol.
Cell 11, 875-884.
- McDonald, J. P., Frank, E. G.,
Plosky, B. S., Rogozin, I. B., Masutani, C., Hanaoka,
F., Woodgate, R., and Gearhart, P. J. (2003) 129-derived
strains of mice are deficient in DNA polymerase?iota
and have normal immunoglobulin hypermutation. J.
Exp. Med. 198, 635-643.
- Vaisman, A., Frank, E. G., Iwai,
S., Ohashi, E., Ohmori, H., Hanaoka, F., and Woodgate,
R. (2003) Sequence context-dependent replication
of DNA templates containing UV-induced lesions by
human DNA polymerase iota. DNA Repair 2, 991-1006.
- Riedl, T., Hanaoka, F., and Egly,
J.-M. (2003) The comings and goings of nucleotide
excision repair factors on damaged DNA. EMBO J. 22,
5293-5303.
- Jaloszynski, P., Masutani, C.,
Hanaoka, F., Perez, A. B., and Nishimura, S. (2003)
8-Hydroxyguanine in a mutational hotspot of the c-Ha-ras
gene causes misreplication, ‘action-at-a-distance’
mutagenesis and inhibition of replication. Nucleic
Acids Res. 31, 6085-6095.
- You, Z., Ishimi, Y., Mizuno, T.,
Sugasawa, K., Hanaoka, F., and Masai, H. (2003) Thymine-rich
single-stranded DNA sequences specifically activates
mouse Mcm4/6/7 helicase on Y-fork and bubble-like
substrates. EMBO J. 22, 6148-6160.
- Bassett, E., Vaisman, A., Havener,
J. M., Masutani, C., Hanaoka, F., and Chaney, S.
G. (2003) Efficiency of extension of mismatched primer
termini across from cisplatin and oxaliplatin adducts
by human DNA polymerases beta and eta in vitro. Biochemistry
42, 14197-14206.
- Ito, N., Nureki, O., Shirouzu,
M., Yokoyama, S., and Hanaoka, F. (2003) Crystal
structure of the Pyrococcus horikoshii DNA primase-UTP
complex: implications for the mechanism of primer
synthesis. Genes Cells 8, 913-923.
- Higurashi, M., Ohtsuki, T., Inase,
A., Kusumoto, R., Masutani, C., Hanaoka, F., and
Iwai, S. (2003) Idenitification and characterization
of an intermediate in the alkali degradation of (6-4)
photoproduct-containing DNA. J. Biol. Chem. 278,
51968-51973.
- Takemoto, A., Kimura, K., Yokoyama,
S., and Hanaoka, F. (2004) Cell cycle-dependent phosphorylation,
nuclear localization, and activation of human condensin.
J. Biol. Chem. 279, 4551-4559.
- Fujiwara, K., Tenno, T., Sugasawa,
K., Jee, J. G., Ohki, I., Kojima, C., Tochio, H.,
Hiroaki, H., Hanaoka, F., and Shirakawa, M. (2004)
Structure of the ubiquitin-interacting motif of S5a
bound to the ubiquitin-like domain of HR23B. J. Biol.
Chem. 279, 4760-4767.
- McCulloch, S. D., Kokoska, R.
J., Masutani, C., Iwai, S., Hanaoka, F., and Kunkel,
T. A. (2004) Preferential cis-syn thymine dimer bypass
by DNA polymerase eta occurs with biased fidelity.
Nature 428, 97-100.
- Kino, K., Shimizu, Y., Sugasawa,
K., Sugiyama, H., and Hanaoka, F. (2004) Nucleotide
excision repair of 5-formyluracil in vitro is enhanced
by the presence of mismatched bases. Biochemistry
43, 2682-2687.
- Takasawa, K., Masutani, C., Hanaoka,
F., and Iwai, S. (2004) Chemical synthesis and translesionreplication
of cis-syn cyclobutane thymine-uracil dimer. Nucleic
Acids Res. 32, 1738-1745.
- Murakami, C., Mizuno, T., Hanaoka,
F., Yoshida, H., Sakaguchi, K., and Mizushina, Y.
(2004) Mechanism of cell cycle arrest by sulfoquinovosyl
monoacylglycerol with a C18-saturated fatty acid
(C18-SQMG). Biochem. Pharmacol. 67, 1373-1380.
- Niimi, A., Limsirichaikul, S.,
Yoshida, S., Iwai, S., Masutani, C., Hanaoka, F.,
Kool, E. T., Nishiyama, Y., and Suzuki, M. (2004)
Palm residue mutants in DNA polymerases alpha and
eta alter DNA replication fidelity and translesion
activity. Mol. Cell. Biol. 24, 2734-2746
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