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Publication list

  1. Tsutsumi-Ishii, Y., Tadokoro, K., Hanaoka, F., and Tsuchida, N. (1995) Response of heat shock element within the human HSP70 promoter to mutated p53 genes. Cell Growth Differ. 6, 1-8.

  2. Shiratori, A., Okumura, K., Nogami, M., Taguchi, H., Onozaki, T., Inoue, T., Ando, T.,Shibata, T., Izumi, M., Miyazawa, H., Hanaoka, F., Murakami, Y., and Eki, T. (1995) Assignment of the 49-kDa (PRIM1) and 58-kDa (PRIM2A and PRIM2B) subunit genes of the human DNA primase to chromosome bands 1q44 and 6p11.1-p12. Genomics 28, 350-353

  3. Matsuda, T., Saijo, M., Kuraoka, I., Kobayashi, T., Nakatsu, Y., Nagai, A.,Enjoji, T., Masutani, C., Sugasawa, K., Hanaoka, F., Yasui, A., and Tanaka, K. (1995) DNA repair protein XPA binds replication protein A (RPA). J. Biol. Chem. 270, 4152-4157.

  4. Kamiya, H., Murata-Kamiya, N., Fujimuro, M., Kido, K., Inoue, H., Nishimura, S., Masutani, C., Hanaoka, F., and Ohtsuka, E. (1995) Comparison of incorporation and extension of nucleotides in vitro opposite 8-hydroxyguanine (7,8-dihydro-8-oxoguanine) in hot spots of the c-Ha-ras gene. Jpn. J. Cancer Res. 86, 270-276.

  5. Matsumoto, K., Okuwaki, M., Kawase, H., Handa, H., Hanaoka, F., and Nagata, K. (1995) Stimulation of DNA transcription by the replication factor from the adenovirus genome in a chromatin-like structure. J. Biol. Chem. 270, 9645-9650.

  6. Sauer, F., Fondell, J. D., Ohkuma, Y., Roeder, R. G., and Jackle, H. (1995) Control of transcription by Kruppel through interactions with TFIIB and TFIIE beta. Nature 375, 162-164.

  7. Eki, T., Hanaoka, F., Kohda, T., Seki, M., Ui, M., and Enomoto, T. (1995) Efficient replication of polyomavirus DNA in a cell-free system supplemented with Escherichia coli single-stranded DNA binding protein, which exhibits species-specificity in the requirement for DNA polymerase alpha-primase. J. Biochem. (Tokyo) 118, 435-441.

  8. Yamaguchi, K., Kobayashi, M., Yamauchi, Y., Tanaka, A., Miyazawa, H., Izumi, M., and Hanaoka, F. (1995) Temperature-sensitive mutation of DNA polymerase alpha induces growth-suppressive phenotypes involving retinoblastoma protein and cyclin D1. Cell Struct. Funct. 20, 285-291.

  9. Kamiya, H., Miura, H., Murata-Kamiya, N., Ishikawa, H., Sakaguchi, T., Inoue, H., Sasaki, T., Masutani, C., Hanaoka, F., Nishimura, S., and Ohtsuka, E. (1995) 8-Hydroxyadenine (7,8-dihydro-8-oxoadenine) induces misincorporation in in vitro DNA synthesis and mutations in NIH 3T3 cells. Nucleic Acids Res. 23, 2893-2899.

  10. Ohkuma, Y., Hashimoto, S., Wang, C.K., Horikoshi, M., and Roeder, R. G. (1995) Analysis of the role of TFIIE in basal transcription and TFIIH-mediated CTD-phosphorylation through structure-function studies of TFIIE-alpha. Mol. Cell. Biol. 15, 4856-4866.

  11. Shimamoto, T., Tanimura, T., Yoneda, Y., Kobayakawa, Y., Sugasawa, K., Hanaoka, F., Oka, M., Okada, Y., Tanaka, K., and Kohno, K. (1995) Expression and functional analyses of the Dxpa gene, the Drosophila homolog of the human excision repair gene XPA. J. Biol. Chem. 270, 22452-22459.

  12. Kagawa, Y., Yatagai, F., Suzuki, M., Kase, Y., Kobayashi, A., Hirano, M., Kato, T., Watanabe, M., and Hanaoka, F. (1995) Analysis of mutations in the human HPRT gene induced by accelerated heavy-ion irradiation. J. Radiat. Res. (Tokyo) 36, 185-195.

  13. Tanaka, M., Sawada, M., Yoshida, S., Hanaoka, F., and Marunouchi, T. (1995) Insulin prevents apoptosis of external granular layer neurons in rat cerebellar slice cultures. Neurosci. Lett. 199, 37-40.

  14. Taguchi, T., Ogihara, M., Maekawa, T., Hanaoka, F., and Tanno, M. (1995) Stimulation of DNA polymerase gamma activity by proliferating cell nuclear antigen. Biochem. Biophys. Res. Commun. 216, 715-722.

  15. Hagiwara, H., Naitou, M., Shibata, T., Hanaoka, F., Eki, T., and Murakami, Y. (1995) Identification of the coding region of Saccharomyces cerevisiae chromosome VI using the computer program GenMark. DNA Res. 2, 247-253.

  16. Naitou, M., Ozawa, M., Sasanuma, S., Kobayashi, M., Hagiwara, H., Shibata, T., Hanaoka, F., Watanabe, K., Ono, A., Yamazaki, M., Tashiro, H. Eki, T., and Murakami, Y. (1995) Sequencing of an 18.8 kb fragment from Saccharomyces cerevisiae chromosome VI. Yeast 11, 1525-1532.

  17. van der Spek, P. J., Visser, C. E., Hanaoka, F., Smit, B., Hagemeijer, A., Bootsma, D., and Hoeijmakers, J. H. (1996) Cloning, comparative mapping, and RNA expression of the mouse homologues of the Saccharomyces cerevisiae nucleotide excision repair gene. RAD23. Genomics 31, 20-27.

  18. Naitou, M., Ozawa, M., Sasanuma, S. I., Kobayashi, M., Hagiwara, H., Shibata, T., Hanaoka, F., Watanabe, K., Ono, A., Yamazaki, M., Tashiro, H., Eki, T., and Murakami, Y. (1996) Sequencing of a 23 kb fragment from Saccharomyces cerevisiae chromosome VI. Yeast 12, 77-84.

  19. Eki, T., Abe, M., Furuya, K., Ahmad, I., Fujishima, N., Kishida, H., Shiratori, A., Onozaki, T., Yokoyama, K., Le Paslier, D., Cohen, D., Hanaoka, F., and Murakami, Y. (1996) A long-range physical map of human chromosome 21q22.1 band from the YAC continuum. Mamm. Genome. 7, 303-311.

  20. Kawakami, K., Masuda, K., Nagano, K., Ohkuma, Y., and Roeder, R. G. (1996) Characterization of the core promoter of Na, K-ATPase a1 subunit gene: Elements required for transcription by RNA polymerase II and III in vitro. Eur. J. Biochem. 237, 440-446.

  21. Eki, T., Naitou, M., Hagiwara, H., Abe, M., Ozawa, M., Sasanuma, S., Sasanuma, M., Tsuchiya, Y., Shibata, T., Watanabe, K., Ono, A., Yamazaki, M., Tashiro, H., Hanaoka, F., and Murakami, Y. (1996) Fifteen open reading frames in a 30.8 kb region of the right arm of chromosome VI from Saccharomyces cerevisiae. Yeast 12, 177-190.

  22. van der Spek, P. J., Eker, A., Rademakers, S., Visser, C., Sugasawa, K., Masutani, C., Hanaoka, F., Bootsma, D., and Hoeijmakers, J. H. (1996) XPC and human homologs of RAD23: intracellular localization and relationship to other nucleotide excision repair complexes. Nucleic Acids Res. 24, 2551-2559.

  23. Ennas, M. G., Suzuki, H., Menegazzi, M., Carcereri, A., Hanaoka, F., Gremo, F., Nieddu, M., and Mezzanotte, R. (1996) On the presence of DNA polymerase alpha in human lymphocyte nuclei and chromosomes. Heredity 77, 186-191.

  24. Sugasawa, K., Masutani, C., Uchida, A., Maekawa, T., van der Spek, P. J., Bootsma, D., Hoeijmakers, J. H., and Hanaoka, F. (1996) HHR23B, a human Rad23 homolog, stimulates XPC protein in nucleotide excision repair in vitro. Mol Cell Biol 16, 4852-4861.

  25. Eki, T., Okumura, K., Amin, A., Ishiai, M., Abe, M., Nogami, M., Taguchi, H., Hurwitz, J., Murakami, Y., and Hanaoka, F. (1996) Mapping of the human homologue (ORC1L) of the yeast origin recognition complex subunit 1 gene to chromosome band 1p32. Genomics 36, 559-561.

  26. Ito, K., Asano, M., Hughes, P., Kohzaki, H., Masutani, C., Hanaoka, F., Kerppola, T., Curran, T., Murakami, Y., and Ito, Y. (1996) c-Jun stimulates origin-dependent DNA unwinding by polyomavirus large T antigen. EMBO J. 15, 5636-5646.

  27. Mizuno, T., Okamoto, T., Yokoi, M., Izumi, M., Kobayashi, A., Hachiya, T., Tamai, K., Inoue, T., and Hanaoka, F. (1996) Identification of the nuclear localization signal of mouse DNA primase: nuclear transport of p46 subunit is facilitated by interaction with p54 subunit. J. Cell Sci. 109, 2627-2636.

  28. Eki, T., Okumura, K., Shiratori, A., Abe, M., Nogami, M., Taguchi, H., Shibata, T., Murakami, Y., and Hanaoka, F. (1996) Assignment of the closest human homologue (DNA2L:KIAA0083) of the yeast Dna2 helicase gene to chromosome band 10q21.3-q22.1. Genomics 37, 408-410.

  29. Saijo, M., Kuraoka, I., Masutani, C., Hanaoka, F., and Tanaka, K. (1996) Sequential binding of DNA repair proteins RPA and ERCC1 to XPA in vitro. Nucleic Acids Res. 24, 4719-4724.

  30. Fujiwara, Y., Masutani, C., Hanaoka, F., and Iwai, S. (1997) Detection, purification and characterization of a protein that binds the (6-4) photoproduct-containing DNA in HeLa cells. Nucleic Acids Symp Ser 37, 277-278.

  31. Mahamed, M. M., Matsukage, A., Date, T., Hanaoka, F., and Yatagai, F. (1997) In vitro DNA synthesis error specificity: A single amino-acid replacement in rat DNA polymerase beta. Environ. Mutagen Res. 19, 7-15.

  32. Osada, H., Cui, C. B., Onose, R., and Hanaoka, F. (1997) Screening of cell cycle inhibitors from microbial metabolites by a bioassay using a mouse cdc2 mutant cell line, tsFT210. Bioorg. Med. Chem. 5, 193-203.

  33. Kojima, S., Kobayashi, A., Gotoh, O., Ohkuma, Y., Fujii-Kuriyama, Y., and Sogawa, K. (1997) Transcriptional activation domain of human BTEB2, a GC box-binding factor. J. Biochem. (Tokyo) 121, 389-396.

  34. Lapenta, V., Chiurazzi, P., van der Spek, P., Pizzuti, A., Hanaoka, F., and Brahe, C. (1997) SMT3A, a human homologue of the S. cerevisiae SMT3 gene, maps to chromosome 21qter and defines a novel gene family. Genomics 40, 362-366.

  35. Ikehata, H., Kaneda, S., Yamao, F., Seno, T., Ono, T., and Hanaoka, F. (1997) Incubation at the nonpermissive temperature induces deficiencies in UV resistance and mutagenesis in mouse mutant cells expressing a temperature-sensitive ubiquitin-activating enzyme (E1). Mol. Cell. Biol. 17, 1484-1489.

  36. Eki, T., Abe, M., Naitou, M., Sasanuma, S. I., Nohata, J., Kawashima, K., Ahmad, I., Hanaoka, F., and Murakami, Y. (1997) Cloning and characterization of novel gene, DCRR1, expressed from Down's syndrome critical region of human chromosome 21q22.2. DNA Seq. 7, 153-164.

  37. Ohkuma, Y. (1997) Multiple functions of general transcription factors TFIIE and TFIIH in transcription: Possible points of regulation by trans-acting factors. (JB Review) J. Biochem. (Tokyo) 122, 481-489.

  38. Naitou, M., Hagiwara, H., Hanaoka, F., Eki, T., and Murakami, Y. (1997) Expression profiles of transcripts from 126 open reading frames in the entire chromosome VI of Saccharomyces cerevisiae by systematic northern analyses.Yeast 13, 1275-1290.

  39. Yokoi, M., Ito, M., Izumi, M., Miyazawa, H., Nakai, H., and Hanaoka, F. (1997) Molecular cloning of the cDNA for the catalytic subunit of plant DNA polymerase alpha and its cell-cycle dependent expression. Genes Cells 2, 695-709.

  40. Sasaki, H., Yatagai, F., Kanai, T., Furusawa, Y., Hanaoka, F., Zhu, W. G., and Mehnati, P. (1997) Dependence of induction of interphase death of Chinese hamster ovary cells exposed to accelerated heavy ions on linear energy transfer. Radiat. Res. 148, 449-454.

  41. Masutani, C., Araki, M., Sugasawa, K., van der Spek, P. J., Yamada, A., Uchida, A., Maekawa, T., Bootsma, D., Hoeijmakers, J. H., and Hanaoka, F. (1997) Identification and characterization of XPC-binding domain of hHR23B. Mol. Cell. Biol. 17, 6915-6923.

  42. Sugasawa, K., Ng, J. M., Masutani, C., Maekawa, T., Uchida, A., van der Spek, P. J., Eker, A. P., Rademakers, S., Visser, C., Aboussekhra, A., Wood, R. D., Hanaoka, F., Bootsma, D., and Hoeijmakers, J. H. (1997) Two human homologs of Rad23 are functionally interchangeable in complex formation and stimulation of XPC repair activity. Mol. Cell. Biol. 17, 6924-6931.

  43. Withers-Ward, E. S., Jowett, J. B., Stewart, S. A., Xie, Y. M., Garfinkel, A., Shibagaki, Y., Chow, S. A., Shah, N., Hanaoka, F., Sawitz, D. G., Armstrong, R. W., Souza, L. M., and Chen, I. S. (1997) Human immunodeficiency virus type 1 Vpr interacts with HHR23A, a cellular protein implicated in nucleotide excision DNA repair. J. Virol. 71, 9732-9742.

  44. Ishiai, M., Dean, F. B., Okumura, K., Abe, M., Moon, K. Y., Amin, A. A., Kagotani, K., Taguchi, H., Murakami, Y., Hanaoka, F., O'Donnell, M., Hurwitz, J., and Eki, T. (1997) Isolation of human and fission yeast homologues of the budding yeast origin recognition complex subunit ORC5: human homologue (ORC5L) maps to 7q22. Genomics 46, 294-298.

  45. Sakamoto, A., Ono, K., Abe, M., Jasmin, G., Eki, T., Murakami, Y., Masaki, T., Toyo-oka, T., and Hanaoka, F. (1997) Both hypertrophic and dilated cardiomyopathies are caused by mutation of the same gene, delta-sarcoglycan, in hamster: an animal model of disrupted dystrophin-associated glycoprotein complex. Proc. Natl. Acad. Sci. USA 94, 13873-13878.

  46. Kimura, M., Matsuda, Y., Eki, T., Yoshioka, T., Okumura, K., Hanaoka, F., and Okano, Y. (1997) Assignment of STK6 to human chromosome 20q13.2-->q13.3 and a pseudogene STK6P to 1q41-->q42. Cytogenet. Cell Genet. 79, 201-203.

  47. Eki, T., Okumura, K., Abe, M., Kagotani, K., Taguchi, H., Murakami, Y., Pan, Z. Q., and Hanaoka, F. (1998) Mapping of the human genes encoding cyclin H (CCNH) and the CDK-activating kinase (CAK) assembly factor MAT1 (MNAT1) to chromosome bands 5q13.3-q14 and 14q23, respectively. Genomics 47, 115-120.

  48. Yamauchi, Y., Tanaka, A., Yamaguchi, K., Kobayashi, M., Shimamura, S., and Hanaoka, F. (1998) Apoptosis was promoted at a nonpermissive temperature in DNA replication-defective temperature-sensitive mutants of mouse FM3A cells. Exp. Cell. Res. 238, 317-323.

  49. Yamauchi, Y., Tanaka, A., Hanaoka, F., and Okumura, K. (1998) A mutant strain of mouse FM3A cells defective in apoptotic DNA fragmentation. Biochem. Biophys. Res. Commun. 243, 550-554.

  50. Carrier, F., Zhan, Q., Alamo, I., Hanaoka, F., and Fornace, A. J., Jr. (1998) Evidence for distinct kinase-mediated pathways in gadd gene responses. Biochem. Pharmacol. 55, 853-861.

  51. Eki, T., Dean, F. B., Kohda, A., Okumura, K., Abe, M., Murakami, Y., Ishiai, M., Satomoto, K., Hurwitz, J., O'Donnell, M., and Hanaoka, F. (1998) Assignment of the homologue of the yeast origin recognition complex subunit ORC4 (ORC4L) to human chromosome band 2q22-->q23 by in situ hybridization and somatic cell hybrid analysis. Cytogenet. Cell. Genet. 81, 89-90.

  52. Kai, M., Todo, T., Wada, M., Ryo, H., Masutani, C., Kobayashi, H., Morioka, H., Ohtsuka, E., Hanaoka, F., and Sakaguchi, K. (1998) A new Drosophila ultraviolet light-damaged DNA recognition endonuclease that selectively nicks a (6-4) photoproduct site. Biochim. Biophys. Acta. 1397, 180-188.

  53. Chino, M., Nishikawa, K., Yamada, A., Ohsono, M., Sawa, T., Hanaoka, F., Ishizuka, M., and Takeuchi, T. (1998) Effect of a novel antibiotic, heliquinomycin, on DNA helicase and cell growth. J. Antibiot. (Tokyo) 51, 480-486.

  54. Mizuno, T., Ito, N., Yokoi, M., Kobayashi, A., Tamai, K., Miyazawa, H., and Hanaoka, F. (1998) The second-largest subunit of the mouse DNA polymerase alpha-primase complex facilitates both production and nuclear translocation of the catalytic subunit of DNA polymerase a. Mol. Cell. Biol. 18, 3552-3562.

  55. Fujita, M., Yamada, C., Tsurumi, T., Hanaoka, F., Matsuzawa, K., and Inagaki, M. (1998) Cell cycle- and chromatin binding state-dependent phosphorylation of human MCM heterohexameric complexes. A role for cdc2 kinase. J. Biol. Chem. 273, 17095-17101.

  56. Okamoto, T., Yamamoto, S., Watanabe, Y., Ohta, T., Hanaoka, F., Roeder, R. G., and Ohkuma, Y. (1998) Analysis of the role of TFIIE in transcriptional regulation through structure-function studies of the TFIIE beta subunit. J. Biol. Chem. 273, 19866-19876.

  57. Sugasawa, K., Ng, J. M., Masutani, C., Iwai, S., van der Spek, P. J., Eker, A. P., Hanaoka, F., Bootsma, D., and Hoeijmakers, J. H. (1998) Xeroderma pigmentosum group C protein complex is the initiator of global genome nucleotide excision repair. Mol. Cell 2, 223-232.

  58. Hoshino, S., Imai, M., Mizutani, M., Kikuchi, Y., Hanaoka, F., Ui, M., and Katada, T. (1998) Molecular cloning of a novel member of the eukaryotic polypeptide chain-releasing factors (eRF). Its identification as eRF3 interacting with eRF1. J. Biol. Chem. 273, 22254-22259.

  59. Ohtaka-Maruyama, C., Hanaoka, F., and Chepelinsky, A. B. (1998) A novel alternative spliced variant of the transcription factor AP2 alpha is expressed in the murine ocular lens. Dev. Biol. 202, 125-135.

  60. Lee, C.-G., Eki, T., Okumura, K., Nogami, M., da Costa Soares, V., Murakami, Y., Hanaoka, F., and Hurwitz, J. (1999, Jan) The human RNA helicase A (DDX9) gene maps to the prostate cancer susceptibility locus at chromosome band 1q25 and its pseudogene (DDX9P) to 13q22, respectively. Somat. Cell Mol. Genet. 25, 33-39.

  61. Shiratori, A., Shibata, T., Arisawa, M., Hanaoka, F., Murakami, Y., and Eki, T. (1999) Systematic identification, classification, and characterization of the open reading frames which encode novel helicase-related proteins in Saccharomyces cerevisiae by gene disruption and Northern analysis. Yeast 15, 219-253.

  62. Kagawa, Y., Shimazu, T., Gordon, A. J. E., Fukunishi, N., Inabe, N., Suzuki, M., Hirano, M., Kato, T., Watanabe, M., Hanaoka, F., and Yatagai, F. (1999) Complex hprt deletion events are recovered after exposure of human lymphoid cells to high-LET carbon and neon ion beams. Mutagenesis 14, 199-205.

  63. Shimada, M., Konishi, Y., Ohkawa, N., Ohtaka-Maruyama, C., Hanaoka, F., Makino, Y., and Tamura, T. (1999) Distribution of AP-2 subtypes in the adult brain. Neuroscience. Res. 33, 275-280.

  64. Iwai, S., Mizukoshi, T., Fujiwara, Y., Masutani, C., Hanaoka, F., and Hayakawa, Y. (1999) Benzimidazolium triflate-activated synthesis of (6-4) photoproduct-containing oligonucleotides and its application. Nucleic Acids Res. 27, 2299-2303.

  65. Masutani, C., Araki, M., Yamada, A., Kusumoto, R., Nogimori, T., Maekawa, T., Iwai, S., and Hanaoka, F. (1999) Xeroderma pigmentosum variant (XP-V) correcting protein from HeLa cells has a thymine dimer bypass DNA polymerase activity. EMBO J. 18, 3491-3501.

  66. Masutani, C., Kusumoto, R., Yamada, A., Dohmae, N., Yokoi, M., Yuasa, M., Araki, M., Iwai, S., Takio, K., and Hanaoka, F. (1999) The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta. Nature 399, 700-704.

  67. Sato, M., Ura, K., Hohmura, K., Tokumasu, F., Yoshimura, S. H., Hanaoka, F., and Takeyasu, K. (1999) Atomic force microscopy sees nucleosome positioning and histone H1-induced compaction in reconstituted chromatin. FEBS Lett. 452, 267-271.

  68. Fujiwara, Y., Masutani, C., Mizukoshi, T., Kondo, J., Hanaoka, F., and Iwai, S. (1999) Characterization of DNA recognition by the human UV-damaged-DNA binding protein. J. Biol. Chem. 274, 20027-20033.

  69. Hiyama, H., Yokoi, M., Masutani, C., Sugasawa, K., Maekawa, T., Tanaka, K., Hoeijmakers, J. H. J., and Hanaoka, F. (1999) Interaction of hHR23 with S5a: The ubiquitin-like domain of hHR23 mediates interaction with S5a subunit of 26S proteasome. J. Biol. Chem. 274, 28019-28025.

  70. Mizuno, T., Yamagishi, K., Miyazawa, H., and Hanaoka, F. (1999) Molecular architecture of the mouse DNA polymerase alpha?primase complex. Mol. Cell. Biol. 19, 7886-7896.

  71. Araki, M., Masutani, C., Maekawa, T., Watanabe, Y., Yamada, A., Kusumoto, R., Sakai, D., Sugasawa, K., Ohkuma, Y., and Hanaoka, F. (2000) Reconstitution of damage DNA excision reaction from SV40 minichromosomes with purified nucleotide excision repair proteins. Mutat. Res. 459, 147-160.

  72. Okuda, M., Watanabe, Y., Okamura, H., Hanaoka, F., Ohkuma, Y., and Nishimura, Y. (2000) Structure of the central core domain of TFIIEb with a novel double-stranded DNA-binding surface. EMBO J. 19, 1346-1356.

  73. Yokoi, M., Masutani, C., Maekawa, T., Sugasawa, K., Ohkuma, Y., and Hanaoka, F. (2000) The xeroderma pigmentosum group C protein complex XPC-HR23B plays an important role in the recruitment of transcription factor IIH to damaged DNA. J. Biol. Chem. 275, 9870-9875.

  74. Nishikawa, N. S., Izumi, M., Uchida, H., Yokoi, M., Miyazawa, H., and Hanaoka, F. (2000) Cloning and characterization of the 5'-upstream sequence governing the cell cycle-dependent transcription of mouse DNA polymerase alpha-p 68-kDa subunit gene. Nucleic Acids Res. 28, 1525-1534.

  75. Vaisman, A., Masutani, C., Hanaoka, F., and Chaney, S. G. (2000) Efficient translesion replication past oxaliplatin and cisplatin GpG adducts by human DNA polymerase eta. Biochemistry 39, 4575-4580.

  76. Matsuda, T., Bebenek, K., Masutani, C., Hanaoka, F., and Kunkel, T. A. (2000) Low fidelity DNA synthesis by human DNA polymerase eta. Nature 404, 1011-1013.

  77. Watanabe, Y., Fujimoto, H., Watanabe, T., Maekawa, T., Masutani, C., Hanaoka, F., and Ohkuma, Y. (2000) Modulation of TFIIH-associated kinase activity by complex formation and its relationship with CTD phosphorylation of RNA polymerase II. Genes Cells 5, 407-423.

  78. Masutani, C., Kusumoto, R., Iwai, S., and Hanaoka, F. (2000) Mechanisms of accurate translesion synthesis by human DNA polymerase eta. EMBO J. 19, 3100-3109.

  79. Yamada, A., Masutani, C., Iwai, S., and Hanaoka, F. (2000) Complementation of defective translesion synthesis and ultraviolet light sensitivity in xeroderma pigmentosum variant cells by human and mouse DNA polymerase eta. Nucleic Acids Res. 28, 2473-2480.

  80. Ohashi, E., Ogi, T., Kusumoto, R., Iwai, S., Masutani, C., Hanaoka, F., and Ohmori, H. (2000) Error-prone bypass of certain DNA lesions by the human DNA polymerase kappa. Genes Dev. 14, 1589-1594.

  81. Izumi, M., Yokoi, M., Nishikawa, N., Miyazawa, H., Sugino, A., Yamagishi, M., Yamaguchi, M., Matsukage, A., Yatagai, F., and Hanaoka, F. (2000) Transcription of the catalytic 180-kDa subunit gene of mouse DNA polymerase alpha is controlled by E2F, an Ets-related transcription factor, and Sp1. Biochim. Biophys. Acta 1492, 341-352.

  82. Miao, F., Bouziane, M., Dammann, R., Masutani, C., Hanaoka, F., Pfeifer, G. P., and O'Connor, T. R. (2000) 3-methyladenine-DNA glycosylase (MPG protein) interacts with huamn RAD23 proteins. J. Biol. Chem. 275, 28433-28438.

  83. Yuasa, M., Masutani, C., Eki, T., and Hanaoka, F. (2000) Genomic structure, chromosomal localization and identification of mutations in the xeroderma pigmentosum variant (XPV) gene. Oncogene, 19, 4721-4728.

  84. Tissier, A., Frank, E. G., McDonald, J. P., Iwai, S., Hanaoka, F., and Woodgate, R. (2000) Misinsertion and bypass of thymine-thymine dimers by human DNA polymerase iota. EMBO J. 19, 5259-5266.

  85. Mizushina, Y., Kamisuki, S., Mizuno, T., Takemura, M., Asahara, H., Linn, S., Yamaguchi, M., Matsukage, A., Hanaoka, F., Yoshida, S., Saneyoshi, M., Sugawara, F., and Sakaguchi, K. (2000) Dehydroaltenusin: A mammalian DNA polymerase alpha inhibitor. J. Biol. Chem. 275, 33957-33961.

  86. Douziech, M., Coin, F., Chipoulet, J.-M., Arai, Y., Ohkuma, Y., Egly, J.-M. and Coulombe, B. (2000) Mechanism of promoter melting by the Xeroderma pigmentosum complementation group B helicase of transcription factor IIH revealed by protein-DNA photo-cross-linking. Mol. Cell. Biol. 20, 8168-8177.

  87. Izumi, M., Yanagi, K., Mizuno, T., Yokoi, M., Kawasaki, Y., Moon, K.-Y., Hurwitz, J., Yatagai, F., and Hanaoka, F. (2000) The human homolog of Saccharomyces cerevisiae Mcm10 interacts with replication factors and dissociates from nuclease-resistant nuclear structures in G2 phase. Nucleic Acids Res. 28, 4769-4777.

  88. Masutani, C., Kusumoto, R., Yamada, A., Yuasa, M., Araki, M., Nogimori, T., Yokoi, M., Eki, T., Iwai, S., and Hanaoka, F. (2000) Xeroderma pigmentosum variant: From a human genetic disorder to a novel DNA polymerase. Cold Spring Harbor Symp. Quant. Biol. 65, 71-80.

  89. Hanaoka, F. (2001) SOS polymerases. Nature 409, 33-34.

  90. Yamamoto, S., Watanabe, Y., van der Spek, P., Watanabe, T., Fujimoto, H., Hanaoka, F., and Ohkuma, Y. (2001) Studies of nematode TFIIE function reveal a link between Ser-5 phosphorylation of RNA polymerase II and the transition from transcription initiation to elongation. Mol. Cell. Biol. 21, 1-15.

  91. Kannouche, P., Broughton, B. C., Volker, M., Hanaoka, F., Mullenders, L. H. F., and Lehmann, A. R. (2001) Domain structure, localization and function of DNA polymerase eta, defective in xeroderma pigmentosum variant cells. Genes Dev. 15, 158-172.

  92. Nishikawa, N. S., Izumi, M., Yokoi, M., Miyazawa, H., and Hanaoka, F. (2001) E2F regulates growth-dependent transcription of genes encoding both catalytic and regulatory subunits of mouse primase. Genes Cells 6, 57-70.

  93. McDonald, J. P., Tissier, A., Frank, E. G., Iwai, S., Hanaoka, F., and Woodgate, R. (2001) DNA polymerase iota and related rad30-like enzymes. Philos. Trans. R. Soc. Lond. B. Biol. Sci. 356, 53-60.

  94. Bebenek, K., Matsuda, T., Masutani, C., Hanaoka, F., and Kunkel, T. A. (2001) Proofreading of DNA polymerase eta-dependent replication errors. J. Biol. Chem. 276, 2317-2320.

  95. Sugasawa, K., Okamoto, T., Shimizu, Y., Masutani, C., Iwai, S., and Hanaoka, F. (2001) Multi-step recognition mechanism in the global genomic nucleotide excision repair. Genes Dev. 15, 507-521.

  96. Mehnali, P., Yatagai, F., Tsuzuki, T., Hanaoka, F., and Sasaki, H. (2001) Judgement on “hit or non-hit” of CHO cells exposed to accelerated heavy-ions (Fe- or Ar-ions) using division delay and CR-39 plastics as an indicator. Fukuoka Igaku Zasshi 92, 46-57.

  97. Kusumoto, R., Masutani, C., Sugasawa, K., Iwai, S., Araki, M., Uchida, A., Mizukoshi, T., and Hanaoka, F. (2001) Diversity of the damage recognition step in the global genomic nucleotide excision repair in vitro. Mutation Res. 485, 219-227.

  98. Ura, K., Araki, M., Saeki, H., Masutani, C., Ito, T., Iwai, S., Mizukoshi, T., Kaneda, Y., and Hanaoka, F. (2001) ATP-dependent chromatin remodeling facilitates nucleotide excision repair of UV-induced DNA lesions in synthetic dinucleosomes. EMBO J. 20, 2004-2014.

  99. Ishikawa, T., Uematsu, N., Mizukoshi, T., Iwai, S., Iwasaki, H., Masutani, C., Hanaoka, F., Ueda, R., Ohmori, H., and Todo, T. (2001) Mutagenic and non-mutagenic bypass of DNA lesions by Drosophila DNA polymerases dpolh and dpoli. J. Biol. Chem. 276, 15155-15163.

  100. Araki, M., Masutani, C., Takemura, M., Uchida, A., Sugasawa, K., Kondoh, J., Ohkuma, Y., and Hanaoka, F. (2001) Centrosome protein centrin2/caltractin1 is part of the xeroderma pigmentosum group C complex that initiates global genome nucleotide excision repair. J. Biol. Chem. 276, 18665-18672.

  101. Levine, R. L., Miller, H., Grollman, A., Ohashi, E., Ohmori, H., Masutani, C., Hanaoka, F., and Moriya, M. (2001) Translesion DNA synthesis catalyzed by human pol eta and pol kappa across 1,N6-ethenodeoxyadenosine. J. Biol. Chem. 276, 18717-18721.

  102. Ohmori, H., Friedberg, E. C., Fuchs, R. P. P., Goodman, M. F., Hanaoka, F., Hinkle, D., Kunkel, T. A., Lawrence, C. W., Livneh, Z., Nohmi, T., Prakash, L., Prakash, S., Todo, T., Walker, G. C., Wang, Z., and Woodgate, R. (2001) The Y-family of DNA polymerases. Mol. Cell 8, 7-8.

  103. Matsuda, T., Bebenek, K., Masutani, C., Rogozin, I. B., Hanaoka. F., and Kunkel, T. A. (2001) Error rate and specificity of human and murine DNA polymerase eta. J. Mol. Biol. 312, 335-346.

  104. Katsumi, S., Kobayashi, N., Imoto, K., Nakagawa, A., Yamashina, Y., Muramatsu, T., Shirai, T., Miyagawa, S., Sugiura, S., Hanaoka, F., Matsunaga, T., Nikaido, O., and Mori, T. (2001) In situ visualization of ultraviolet-light-induced DNA damage repair in locally irradiated human fibroblasts. J. Invest. Dermatol. 117, 1156-1161.

  105. Boudsocq, F., Iwai, S., Hanaoka, F., and Woodgate, R. (2001) Sulfolobus solfataricus P2 DNA polymerase IV (Dpo4): an archaeal DinB-like DNA polymerase with lesion-bypass properties akin to eukaryotic pol eta. Nucleic Acids Res. 29, 4607-4616.

  106. Burgers, P. M., Koonin, E. V., Bruford, E., Blanco, L., Burtis, K. C., Christman, M. F., Copeland, W. C., Friedberg, E. C., Hanaoka, F., Hinkle, D. C., Lawrence, C. W., Nakanishi, M., Ohmori, H., Prakash, L., Prakash, S., Reynaud, C. A., Sugino, A., Todo, T., Wang, Z., Weill, J. C., and Woodgate, R. (2001) Eukaryotic DNA polymerases: proposal for a revised nomenclature. J. Biol. Chem. 276, 43487-43490.

  107. Izumi, M., Yatagai, F., and Hanaoka, F. (2001) Cell cycle-dependent proteolysis and phosphorylation of human Mcm10. J. Biol. Chem. 276, 48526-48531.

  108. Ito, N., Nureki, O., Shirouzu, M., Yokoyama, S., and Hanaoka, F. (2001) Crystallization and preliminary X-ray analysis of a DNA primase from the hyperthermophilic archaeon, Pyrococcus horikoshii. J. Biochem. (Tokyo) 130, 727-730.

  109. Kuraoka, I., Robins, P., Masutani, C., Hanaoka, F., Gasparutto, D., Cadet, J., Wood, R. D., and Lindahl, T. (2001) Oxygen free-radical damage to DNA: translesion synthesis by DNA polymerase eta and resistance to exonuclease action at cyclopurine deoxynucleoside residues. J. Biol. Chem. 276, 49283-49288.

  110. Yatagai, F., Nohmi, T., Kusakabe, M., Masumura, K., Yoshiki, A., Yamaguchi, H., Kurobe, T., Kuniya, K., Hanaoka, F., and Yano, Y. (2001) Mutation induction by heavy-ion irradiation of gpt delta transgenic mice. Phys. Med. 17, 192-193.

  111. Sugasawa, K., Shimizu, Y., Iwai, S., and Hanaoka, F. (2002) A molecular mechanism for DNA damage recognition by the xeroderma pigmentosum group C protein complex. DNA Repair 1, 95-107.

  112. Broughton, B. C., Cordonier, A., Kleijer, W. J., Jaspers, N. G., Fawcett, H., Raams, A., Garritsen, V. H., Stary, A., Avril, M. F., Boudsocq, F., Masutani, C., Hanaoka, F., Fuchs, R. P., Sarasin, A., and Lehmann, A. R. (2002) Molecular analysis of mutations in DNA polymerase eta in xeroderma pigmentosum-variant patients. Proc. Natl. Acad. Sci. USA 99, 815-820.

  113. Ng, J. M., Vrieling, H., Sugasawa, K., Ooms, M. P.,. Grootegoed, J. A., Vreeburg, J. T. M., Visser, P., Beems, R. B., Gorgels, T. G. M. F., Hanaoka, F., Hoeijmakers, J. H. J., and van der Horst, G. T. J. (2002) Developmental defects and male sterility in mice lacking the ubiquitin-like DNA repair gene mHR23B. Mol. Cell. Biol. 22, 1233-1245.

  114. Nakanishi, A., Imajoh-Ohmi, S., and Hanaoka, F. (2002) Characterization of the interaction between GyrI (DNA gyrase inhibitor) and DNA gyrase of Escherichia coli. J. Biol. Chem. 277, 8949-8954.

  115. Wada, M., Miyazawa, H., Wang, R.-S.,Mizuno, T., Sato, A., Asashima, M., and Hanaoka, F. (2002) The second subunit of mouse DNA polymerase epsilon, DPE2, interacts with SAP18 and recruits the Sin3 Co-repressor protein to DNA. J. Biochem. (Tokyo) 131, 307-311.

  116. Chiapperino, D., Kroth, H., Kramarczuk, I., Sayer, J. M., Masutani, C., Hanaoka, F., Jerina, D. M., and Cheh, A. M. (2002, Apr) Preferential misincorporation of purine nucleotides by human DNA polymerase eta opposite benzo[a]pyrene 7,8-diol 9,10-epoxide deoxyguanosine adducts. J. Biol. Chem. 277, 11765-11771.

  117. Ahmad, S. I., Hanaoka, F., and Kirk, S. H. (2002) Molecular biology of Fanconi anaemia ? an old problem, a new insight. BioEssays 24, 439-448.

  118. Morimoto, S., Kato, T., Honma, M., Hayashi, M., Hanaoka, F., and Yatagai, F. (2002) Detection of genetic alterations induced by low-dose X rays: analysis of loss of heterozygosity for TK mutation in human lymphoblastoid cells. Radiat. Res. 157, 533-538.

  119. Kusumoto, R., Masutani, C., Iwai, S., and Hanaoka, F. (2002) Translesion synthesis by human DNA polymerase eta across thymins glycol lesions. Biochemistry, 41, 6090-6099.

  120. Hey, T., Lipps, G., Sugasawa, K., Iwai, S., Hanaoka, F., and Krauss, G. (2002) The XPC-HR23B complex displays high addinity and specificity for damaged DNA in a true-equilibrium fluorescence assay. Biochemistry, 41, 6583-6587.

  121. Uchida, A., Sugasawa, K., Masutani, C., Dohmae, N., Araki, M., Yokoi, M., Ohkuma, Y., and Hanaoka, F. (2002) The carboxy-terminal domain of the XPC protein plays a crucial role in nucleotide excision repair through interactions with transcription factor IIH. DNA Repair, 1, 449-461.

  122. Pavlov, Y. I., Rogozin, I. B., Galkin, A. P., Aksenova, A. Y., Hanaoka, F., Rada, C., and Kunkel, T. A. (2002) Correlation of somatic hypermuqtation specificity and A-T base pair substitution errors by DNA polymerase eta during copying of a mouse immunoglobulin kappa light chain transgene. Proc. Natl. Acad. Sci. USA, 99, 9954-9959.

  123. Fukumoto, Y., Hiyama, H., Yokoi, M., Nakaseko, Y., Yanagida, M., and Hanaoka, F. (2002) Two budding yeast RAD4 homologs in fission yeast play different roles in the repair of UV-induced DNA damage. DNA Repair, 10, 855-868.

  124. Yamada, A., Masutani, C., and Hanaoka, F. (2002) Detection of reduced RNA synthesis in UV-irradiated Cockayne syndrome group B cells using an isolated nuclear system. Biochim. Biophys. Acta, 1592, 129-134.

  125. Yanagi, K., Mizuno, T., You, Z., and Hanaoka, F. (2002) Mouse geminin inhibits not only Cdt1-MCM6 interactions but also a novel intrinsic Cdt1 DNA binding activity. J. Biol. Chem. 277, 40871-40880.

  126. You, Z., Ishimi, Y., Masai, H., and Hanaoka, F. (2002) Roles of Mcm7 and Mcm4 subunits in DNA helicase activity of mouse Mcm4/6/7 complex. J. Biol. Chem. 277, 42471-42479.

  127. Servant, L., Cazaux, C., Bieth, A., Iwai, S., Hanaoka, F., and Hoffmann, J. S. (2002) A role for DNA polymerase beta?in mutagenic UV lesions bypass. J. Biol. Chem. 277, 50046-50053.

  128. Bassett, E., Vaisman, A., Tropea, K. A., McCall, C. M., Masutani, C., Hanaoka, F., and Chaney, S. G. (2002) Frameshifts and deletions during in vitro translesion synthesis past Pt-DNA adducts by DNA polymerases beta and eta. DNA Repair 1, 1003-1016.

  129. Shimizu, Y., Iwai, S., Hanaoka, F., and Sugasawa, K. (2003) Xeroderma pigmentosum group C protein interacts physically and functionally with thymine DNA glycosylase. EMBO J. 22, 164-173.

  130. Janicievic, A., Sugasawa, K., Shimizu, Y., Hanaoka, F., Wijgers, N., Djurica, M., Hoeijmakers, J. H. J., and Wyman, C. (2003) DNA bending by the human damage recognition complex XPC-HR23B. DNA Repair 2, 325-336.

  131. Shimizu, M., Gruz, P., Kamiya, H., Kim, S.-R., Pisani, F. M., Masutani, C., Kanke, Y., Harashima, H., Hanaoka, F., and Nohmi, T. (2003) Erroneous incorporation of oxidized DNA precursors by Y-family DNA polymerases. EMBO Rep. 4, 269-273.

  132. Watanabe, T., Hayashi, K., Tanaka, A., Furumoto, T., Hanaoka, F., and Ohkuma, Y. (2003) The carboxy terminus of the small subunit of TFIIE regulates the transition from transcription initiation to elongation by RNA polymerase II. Mol. Cell. Biol. 23, 2914-2926.

  133. Yang, I. Y., Miller, H., Wang, Z., Frank, E. G., Ohmori, H., Hanaoka, F., and Moriya, M. (2003) Mammalian translesion DNA synthesis across an acrolen-derived deoxyguanosine adduct: Participation of DNA polymerase eta in error-prone synthesis in human cells. J. Biol. Chem. 278, 13989-13994.

  134. Friedberg, E. C., Hanaoka, F., Tanaka, K., Wilson, S. H., and Yasui, A. (2003) Report on the First US-Japan DNA Repair Meeting. Sendai, Japan, October 27-31, 2002. DNA Repair 2, 639-652.

  135. Kamada, K., Hanaoka, F., and Burley, S. K. (2003) Crystal structure of the MazE/MazF complex. Molecular bases of antidote-toxin recognition. Mol. Cell 11, 875-884.

  136. McDonald, J. P., Frank, E. G., Plosky, B. S., Rogozin, I. B., Masutani, C., Hanaoka, F., Woodgate, R., and Gearhart, P. J. (2003) 129-derived strains of mice are deficient in DNA polymerase?iota and have normal immunoglobulin hypermutation. J. Exp. Med. 198, 635-643.

  137. Vaisman, A., Frank, E. G., Iwai, S., Ohashi, E., Ohmori, H., Hanaoka, F., and Woodgate, R. (2003) Sequence context-dependent replication of DNA templates containing UV-induced lesions by human DNA polymerase iota. DNA Repair 2, 991-1006.

  138. Riedl, T., Hanaoka, F., and Egly, J.-M. (2003) The comings and goings of nucleotide excision repair factors on damaged DNA. EMBO J. 22, 5293-5303.

  139. Jaloszynski, P., Masutani, C., Hanaoka, F., Perez, A. B., and Nishimura, S. (2003) 8-Hydroxyguanine in a mutational hotspot of the c-Ha-ras gene causes misreplication, ‘action-at-a-distance’ mutagenesis and inhibition of replication. Nucleic Acids Res. 31, 6085-6095.

  140. You, Z., Ishimi, Y., Mizuno, T., Sugasawa, K., Hanaoka, F., and Masai, H. (2003) Thymine-rich single-stranded DNA sequences specifically activates mouse Mcm4/6/7 helicase on Y-fork and bubble-like substrates. EMBO J. 22, 6148-6160.

  141. Bassett, E., Vaisman, A., Havener, J. M., Masutani, C., Hanaoka, F., and Chaney, S. G. (2003) Efficiency of extension of mismatched primer termini across from cisplatin and oxaliplatin adducts by human DNA polymerases beta and eta in vitro. Biochemistry 42, 14197-14206.

  142. Ito, N., Nureki, O., Shirouzu, M., Yokoyama, S., and Hanaoka, F. (2003) Crystal structure of the Pyrococcus horikoshii DNA primase-UTP complex: implications for the mechanism of primer synthesis. Genes Cells 8, 913-923.

  143. Higurashi, M., Ohtsuki, T., Inase, A., Kusumoto, R., Masutani, C., Hanaoka, F., and Iwai, S. (2003) Idenitification and characterization of an intermediate in the alkali degradation of (6-4) photoproduct-containing DNA. J. Biol. Chem. 278, 51968-51973.

  144. Takemoto, A., Kimura, K., Yokoyama, S., and Hanaoka, F. (2004) Cell cycle-dependent phosphorylation, nuclear localization, and activation of human condensin. J. Biol. Chem. 279, 4551-4559.

  145. Fujiwara, K., Tenno, T., Sugasawa, K., Jee, J. G., Ohki, I., Kojima, C., Tochio, H., Hiroaki, H., Hanaoka, F., and Shirakawa, M. (2004) Structure of the ubiquitin-interacting motif of S5a bound to the ubiquitin-like domain of HR23B. J. Biol. Chem. 279, 4760-4767.

  146. McCulloch, S. D., Kokoska, R. J., Masutani, C., Iwai, S., Hanaoka, F., and Kunkel, T. A. (2004) Preferential cis-syn thymine dimer bypass by DNA polymerase eta occurs with biased fidelity. Nature 428, 97-100.

  147. Kino, K., Shimizu, Y., Sugasawa, K., Sugiyama, H., and Hanaoka, F. (2004) Nucleotide excision repair of 5-formyluracil in vitro is enhanced by the presence of mismatched bases. Biochemistry 43, 2682-2687.

  148. Takasawa, K., Masutani, C., Hanaoka, F., and Iwai, S. (2004) Chemical synthesis and translesionreplication of cis-syn cyclobutane thymine-uracil dimer. Nucleic Acids Res. 32, 1738-1745.

  149. Murakami, C., Mizuno, T., Hanaoka, F., Yoshida, H., Sakaguchi, K., and Mizushina, Y. (2004) Mechanism of cell cycle arrest by sulfoquinovosyl monoacylglycerol with a C18-saturated fatty acid (C18-SQMG). Biochem. Pharmacol. 67, 1373-1380.

  150. Niimi, A., Limsirichaikul, S., Yoshida, S., Iwai, S., Masutani, C., Hanaoka, F., Kool, E. T., Nishiyama, Y., and Suzuki, M. (2004) Palm residue mutants in DNA polymerases alpha and eta alter DNA replication fidelity and translesion activity. Mol. Cell. Biol. 24, 2734-2746

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