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Organismal Biosystems Laboratories Human Cell Biology Group (Prof. Tanaka)
Nanobiology Laboratories
Soft Biosystem Group
Protonic NanoMachine Group
Sensory Transduction Group

Biomolecular Networks Laboratories
Research Group of Lipid Biosignals
Biomolecular Dynamics Group
Developmental Biology Group
Chromosome Replication Group

Integrated Biology Laboratories
Laboratory of Genetics
Pathology Division
KOKORO-Biology Group
Cellular Biology Group

Organismal Biosystems Laboratories
Laboratory of Developmental Immunology
Developmental Genetics Group
Human Cell Biology Group 
Medicine and Pathophysiology Group

Neuroscience Laboratories
Visual Neuroscience Group
Developmental and Functional Neuroscience Group
Cognitive Neuroscience Group
Cellular and Molecular Neurobiology Group
Synaptic Plasticity Group

Biophysical Dynamics Laboratories
Physiological Laboratory
Nonequilibrium Physics Group
Functional Proteomics Group
Nano-Biophotonics Group

Biomedical Engineering Laboratories
Systems Neuroscience Group
Department of Molecular Genetics
Laboratory of Intercellular Communications
Laboratory of Stem Cell Research
Laboratory of Protein Informatics
Laboratory of Biocatalysis Science

Collaborative institutes
Laboratory of Immune Regulation Chugai Pharmaceutical CO.,LTD.
Optical Nano Device Group
OMRON Corporation

Lab. Members

 Yoko HIROOKA  Secretary
 Keiko NARITA  Technician
 Hiroaki MURAI  Research Associate
 Arato TAKEDACHI  Med. Grad. Student, Doctor course grade 4
 Kyoko SUZUKI  Grad. Student, Doctor course grade 5
 Li Jing TAN  Grad. Student, Doctor course grade 3
 Ayumi SHIMODA  Grad. Student, Doctor course grade 2
 Xue ZHANG  Grad. Student, Doctor course grade 2
 Sayaka KOUNO  Grad. Student, Doctor course grade 2
 Masashi TANIMOTO  Grad. Student, Doctor course grade 2
 Hisami SUETOMO  Grad. Student, Doctor course grade 1
 Dawn KOH XIN PING  Research Student


  Publications

  1. Lin Ni, Makio Saeki, Li Xu, Hirokazu Nakahara, Masafumi Saijo, Kiyoji Tanaka, and Yoshinori Kamisaki. RPAP3 interacts with Reptin to regulate UV-induced phosphorylation of H2AX and DNA damage. J. Cellular Biochemistry, in press.

  2. Kiyoji Tanaka and Shinsuke Ito. Transcription-Coupled Repair and Its Defect in Cockayne Syndrome. In “Molecular Mechanisms of Cockayne Syndrome”. Landes Bioscience, in press (to be published on April 1, 2009)

  3. Hironobu Nakane, Seiichi Hirota, Philip J. Brooks, Yusaku Nakabeppu, Yoshimichi Nakatsu, Yoshitake Nishimune, Akihiro Iino and Kiyoji Tanaka. Impaired spermatogenesis and elevated spontaneous tumorigenesis in xeroderma pigmentosum group A gene (Xpa)-deficient mice. DNA Repair, 7: 1938-1950, 2008.

  4. Isao Kuraoka, Shinsuke Ito, Tadashi Wada, Mika Hayashida, Lily Lee, Masafumi Saijo, Yoshimichi Nakatsu, Megumi Matsumoto, Tsukasa Matsunaga, Hiroshi Handa, Jun Qin, Yoshihiro Nakatani and Kiyoji Tanaka. Isolation of XAB2 complex involved in pre-mRNA splicing, transcription and transcription-coupled repair. J. Biological Chemistry, 283: 940-950, 2008.

  5. Takashi Narita, Tetsu M. C. Yung, Junichi Yamamoto, Yasunori Tsuboi, Hideyuki Tanabe, Kiyoji Tanaka, Yuki Yamaguchi, and Hiroshi Handa. Molecular Cell, 26: 349-365, 2007.

  6. Shinsuke Ito, Isao Kuraoka, Pierre Chymkowitch, Emmanuel Compe, Arato Takedachi, Chie Ishigami, Frederic Coin, Jean-Marc Egly and Kiyoji Tanaka.XPG stabilizes TFIIH allowing transactivation of nuclear receptors: Implications for Cockayne syndrome in XP-G/CS patients. Molecular Cell, 26: 231-243, 2007.

  7. Kawanishi Masanobu, Matsukawa Kazuki, Kuraoka Isao, Takamura-Enya Takeji, Totsuka Yukari, Matsumoto Yasuko, Watanabe Masahiko, Zou Yue, Tanaka Kiyoji, Sugimura Takashi, Wakabayashi Keiji. and Yagi Takashi. Molecular evidence of involvement of nucleotide excision repair (NER) system in repair of the mono ADP-ribosylated DNA adduct produced by pierisin-1, an apoptosis-inducing protein from cabbage butterfly. Chemical Research in Toxicology, 20: 694-700, 2007.

  8. Isao Kuraoka, Kyoko Suzuki, Shinsuke Ito, Mika Hayashida, Joan Seah Mei Kwei, Takahisa Ikegami, Hiroshi Handa, Yusaku Nakabeppu and Kiyoji Tanaka. RNA polymerase II bypasses 8-oxoguanine in the presence of transcription elongation factor TFIIS. DNA Repair, 6: 841-851, 2007.

  9. Tsuyoshi Ikura, Satoshi Tashiro, Akemi Kakino, Hiroki Shima, Naduparambil Jacob, Ravindra Amunugama, Kristine Yoder, Shunsuke Izumi, Isao Kuraoka, Kiyoji Tanaka, Hiroshi Kimura, Masae Ikura, Shuichi Nishikubo, Takashi Ito, Akihiko Muto, Kiyoshi Miyagawa, Shunichi Takeda, Richard Fishel, Kazuhiko Igarashi and Kenji Kamiya. DNA damage-dependent acetylation and ubiquitination of H2AX enhances chromatin dynamics. Molecular and Cellular Biology, 27: 7028-7040, 2007.

  10. Masafumi Saijo, Tamami Hirai, Akiko Ogawa, Aki Kobayashi, Shinya Kamiuchi, and Kiyoji Tanaka. Functional TFIIH is required for UV-induced translocation of CSA to nuclear matrix. Molecular and Cellular Biology, 27: 2538-2547, 2007.

  11. Hironobu Ikehata, Tetsuya Ono, Kiyoji Tanaka and Takeshi Todo. Triplet mutations result from error-prone translesional DNA synthesis on UV photolesions. DNA Repair., 6: 658-668, 2007.

  12. Ingrid van der Pluijm, George A. Garinis, Renata M.C. Brandt, Theo G.M.F. Gorgels, Susan W. Wijnhoven, Karin E.M. Diderich, Jan de Wit, James R. Mitchell, Conny van Oostrom, Rudolf Beems, Laura J. Niedernhofer, Susana Velasco, Errol C. Friedberg, Kiyoji Tanaka, Harry van Steeg, Jan H.J. Hoeijmakers, and Gijsbertus T.J. van der Horst. Impaired genome maintenance suppresses the GH/IGF1 axis in Cockayne syndrome mice. PLoS Biology, 5: 23-38, 2007.

  13. Hironobu Ikehata, Fumitaka Yanase, Toshio Mori, Osamu Nikaido, Kiyoji Tanaka and Tetsuya Ono. Mutation spectrum in UVB-exposed skin epidermis of Xpa-knockout mice: frequent recovery of triplet mutations. Environ. Mol. Mutagen., 48: 1-13, 2007

  14. Inger-Lise Steffensen, Herman A.J. Schut, Jahn M. Nesland, Kiyoji Tanaka, and Jan Alexander. Role of nucleotide excision repair deficiency in intestinal tumorigenesis in multiple intestinal neoplasia (Min) mice. Mutation Research, Genetic Toxicology and Environmental Mutagenesis, 611:71-82, 2006.

  15. Isao Kuraoka and Kiyoji Tanaka. Assays for transcription elongation by RNA polymerase II using oligo(dC)-tailed template with single DNA damage. Methods Enzymol., 408: 214-223, 2006

  16. Regina Groisman, Isao Kuraoka, Odile Chevallier, Nogaye Gaye, Thierry Magnaldo, Kiyoji Tanaka, Alexei F. Kisselev, Annik Harel-Bellan and Yoshihiro Nakatani. CSA-dependent degradation of CSB by ubiquitin-proteasome pathway establishes a link between complementation factors of the Cockayne syndrome. Genes & Development, 20: 1429-1434, 2006 .

  17. Hiroko Miyauchi-Hashimoto, Akira Sugihara, Kiyoji Tanaka and Takeshi Horio. Ultraviolet radiation-induced impairment of tumor rejection is enhanced in xeroderma pigmentosum A gene-deficient mice. J. Invest. Dermatol., 124: 1313-1317, 2005.

  18. Taketo Itoh, Hiroko Miyauchi-hashimoto, Akira Sugihara, Kiyoji Tanaka and Takeshi Horio. The photocarcinogenesis of antibiotic lomefloxacin and UVA radiation is enhanced in xeroderma pigmentosum group A gene-deficient mice. J. Investigative Dermatology, 125. 554-559, 2005.

  19. Lioudmila Solovjeva, Maria Svetlova, Lioudmila Sasina, Kiyoji Tanaka, Masafumi Saijo, Igor Nazarov, Morton Bradbury and Nikolai Tomilin. High mobility of Flap endonuclease 1 and DNA polymerase eta associated with replication foci in mammalian S-phase nucleus.  Molecular Biology of the Cell, 2005 May;16(5):2518-28.

  20. Kaoru Sugasawa, Yuki Okuda, Masafumi Saijo, Ryotaro Nishi, Noriyuki Matsuda, Gilbert Chu, Toshio Mori, Shigenori Iwai, Keiji Tanaka, Kiyoji Tanaka and Fumio Hanaoka. UV-induced ubiquitylation of XPC protein mediated by UV-DDB-ubiquitin ligase complex. Cell,2005 May 6;121(3):387-400.

  21. Fumikazu Yamazaki, Hiroyuki Okamoto, Yasuhiro Matsumura, Kiyoji Tanaka, Takahiro Kunisada and Takeshi Horio. Development of a new mouse model (XPA-deficient, stem cell factor-transgenic) of UVB-induced melanoma. J. Investigative Dermatology, 125, 521-525, 2005.

  22. Noriyuki Matsuda,Keiko Azuma, Masafumi Saijo, Shun-ichiro Iemura, Yusaku Hioki, Tohru Natsume,Tomoki Chiba, Kiyoji Tanaka and Keiji Tanaka. DDB2, the xeroderma pigmentosum group E gene product, is directly ubiquitylated by Cullin 4A-based ubiquitin ligase complex. DNA Repair, 2005 May 2;4(5):537-45.

  23. Rie Yonemasu, Mitsuyoshi Minami, Yoshimichi Nakatsu, Masayo Takeuchi, Isao Kuraoka, Yoichi Matsuda, Yujiro Higashi, Hisato Kondoh and Kiyoji Tanaka. Disruption of mouse XAB2 gene involved in pre-mRNA splicing, transcription and transcription-coupled DNA repair results in preimplantation lethality. DNA Repair, 4, 479-491, 2005.

  24. Naoko Shiomi, Masahiko Mori, Seiji Kito, Yoshi-Nobu Harada, Kiyoji Tanaka and Tadahiro Shiomi. Severe growth retardation and short life span of double mutant mice lacking Xpa and Exon 15 of Xpg. DNA Repair, 4, 351-357, 2005.

  25. Errol C. Friedberg, Fumio Hanaoka, Kiyoji Tanaka, Akira Yasui and Samuel H. Wilson. The 2nd US-Japan DNA Repair Meeting, Honolulu, Hawaii, June 4-8, 2004. DNA Repair, 3, 1661-1674, 2004.

  26. Katsuyoshi Horibata, Yuka Iwamoto, Isao Kuraoka, Nicolaas G. J. Jaspers, Masahiro Kurimasa, Mitsuo Oshimura, Masamitsu Ichihashi and Kiyoji Tanaka.Complete absence of Cockayne syndrome group B gene product gives rise to UV-sensitive syndrome but not Cockayne syndrome.Proc. Natl. Acad. Sci., USA, Oct 26;101(43):15410-5,2004.

  27. Masafumi Saijo, Toshiro Matsuda, Isao Kuraoka and Kiyoji Tanaka.Inhibition of nucleotide excision repair by anti-XPA monoclonal antibodies which interfere with binding to RPA, ERCC1 and TFIIH.Biochemical and Biophysical Research Communications, 321, 815-822, 2004.

  28. Joan Seah Mei Kwei, Isao Kuraoka, Katsuyoshi Horibata, Manabu Ubukata, Eiry Kobatake, Shigenori Iwai, Hiroshi Handa and Kiyoji Tanaka.Blockage of transcription elongation by mammalian RNA polymearse II at cyclobutane pyrimidine dimer and 6-4 photoproduct.Biochemical and Biophysical Research Communications, 320, 1133-1138, 2004.

  29. Fumikazu Yamazaki, Hiroyuki Okamoto, Hiroko Miyauchi-Hashimoto, Yasuhiro Matsumura, Taketo Itoh, Kiyoji Tanaka, Takehiro Kunisada and Takeshi Horio. XPA gene-deficient, SCF-transgenic mice with epidermal melanin are resistant to UV-induced carcinogenesis.J. Investigative Dermatology, 123, 220-228, 2004.

  30. G. E. Kisby, H. Lesselroth, A. Olivas, L. Samson, B. Gold, K. Tanaka, M. S. Turker. Role of nucleotide- and base-excision repair in genotoxin-induced neuronal cell death.DNA Repair, 3, 617-627, 2004.

  31. Li Lan, Tsuyuko Hayashi, Rokshana M. rabeya, Satoshi Nakajima, Shin-ichiro Kanno, Masashi Takao, Tsukasa Matsunaga, Masafumi Yoshino, Minoru Ichikawa, Hein te Riele, Shigeru Tsuchiya, Kiyoji Tanaka and Akira Yasui.Functional and physical interactions between ERCC1 and MSH2 complexes for resistance to cis-diamminedichloroplatinum (II) in mammalian cells.DNA Repair, 3, 135-143, 2004.

  32. Naoto Inukai, Yuki Yamaguchi, Isao Kuraoka, Tomoko Yamada, Sachiko Kamijo, Junko Kato, Kiyoji Tanaka and Hiroshi Handa.A novel hydrogen peroxide-induced phosphorylation and ubiquitination pathway leading to RNA polymerase II proteolysis.Journal of Biological Chemistry, 279, 8190-8195, 2004

  33. Errol C. Friedberg, Fumio Hanaoka, Kiyoji Tanaka, Samuel H. Wilson, Akira Yasui.Report on the First US-Japan DNA Repair Meetin, Sendai, Japan, October 27-31, 2002DNA repair, 2, 639-652, 2003

  34. Regina Groisman, Jolanta Polanowska, Isao Kuraoka, Jun-ichi Sawada, Masafumi Saijo, Ronny Drapkin, Alexei F. Kisselev, Kiyoji Tanaka and Yoshihiro Nakatani.The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage.Cell, 113, 357-367, 2003.

  35. Yan Ren, Masafumi Saijo, Yoshimichi Nakatsu, Hiroshi Nakai, Masaru Yamaizumi and Kiyoji Tanaka.Three novel mutations responsible for Cockayne syndrome group A.Genes & Genetic Systems, 78, 93-102, 2003.

  36. Isao Kuraoka, Masaki Endou, Yuki Yamaguchi, Tadashi Wada, Hiroshi Handa and Kiyoji Tanaka.Effects of endogeneous DNA base lesions on transcription elongation by mammalian RNA polymerase II:Implications for transcription-coupled DNA repair and transcriptional mutagenesis.J. Biological Chemistry, 278, 7294-7299, 2003.

  37. Takehiro Kobayashi, Makoto Uchiyama, Shuhei Fukuro and Kiyoji Tanaka.Mutations in the XPD gene in xeroderma pigmentosum group D cell strains.American Journal of Medical Genetics, 110, 248-252, 2002.

  38. Masafumi Yoshino, Yoshimichi Nakatsu, Hein te Riele, Seiichi Hirota, Yukihiko Kitamura and Kiyoji Tanaka.Additive roles of XPA and MSH2 genes in UVB-induced skin tumorigenesis in mice.DNA Repair, 1, 935-940, 2002.

  39. Tomoo Ogi, Yoichi Shinkai, Kiyoji Tanaka and Haruo Ohmori.Pol kappa protects mammalian cells against the lethal and mutagenic effects of benzo[a]pyrene.Proc. Natl. Acad. Sci., USA, 99, 15548-15553, 2002.

  40. Takahashi Y., Nakatsuru Y., Zhang S., Shimizu Y., Tanaka K., Ide F. and Ishikawa T. (2002) Enhanced spontaneous and aflatoxin-induced liver tumorigenesis in xeroderma pigmentosum group A gene-deficient mice. Carcinogenesis 23, 627-633.

  41. Kamiuchi S., Saijo M., Citterio E., de Jager M., Hoeijmakers JHJ. and Tanaka K. (2002) Translocation of Cockayne syndrome group A protein to the nuclear matrix :possible relevance to transcription-coupled DNA repair. Proc. Natl. Acad. Sci. USA 99, 201-206.

  42. Takeshi Horio, Hiroko Miyauchi-Hashimoto, Kazue Kuwamoto, Satoshi Horiki, Hiroyuki Okamoto and Tanaka K. (2001) Photobiologic and photoimmunologic characteristics of XPA gene-deficient mice. J. Investigative Dermatology Symposium Proceedings 6, 58-63.

  43. Murai M., Enokido Y., Inamura N., Yoshino M., Nakatsu Y., van der Horst GTJ., Hoeijmakers JHJ., Tanaka K., and Hatanaka H. (2001) Early postnatal ataxia and abnormal cerebellar development in mice lacking xeroderma pigmentosum group A and the Cockayne syndrome group B DNA repair genes. Proc. Natl. Acad. Sci., USA 98, 13379-13384.

  44. Ishikawa T., Ide F., Qin X., Zhang S., Takahashi Y., Sekiguchi M., Tanaka K. and Nakatsuru Y. (2001) Importance of DNA repair in carcinogenesis:evidence from transgenic and gene targeting studies. Mutation Research 477, 41-49.

  45. Tanaka K., Kamiuchi S., Ren Y., Yonemasu R., Ichikawa M., Murai H., Yoshino M., Takeuchi S., Saijo M., Nakatsu Y., Miyauchi-Hashimoto H. and Horio T. (2001) UV-induced skin carcinogenesis in xeroderma pigmentosum group A (XPA) gene-knockout mice with nucleotide excision repair-deficiency. Mutation Research 477, 31-40.

  46. Ide F., Iida N., Oda H., Nakatsuru Y., Tanaka K. and Ishikawa T. (2001) Xeroderma pigmentosum group A gene action as a protection factor against 4-nitroquinoline-1-oxide-induced tongue carcinogenesis. Carcinogenesis 22, 567-572.

  47. Miyauchi-Hashimoto H., Kuwamoto K., Urade Y., Tanaka K. and Horio T. (2001) Carcinogen-induced inflammation and immunosuppression are enhanced in xeroderma pigmentosum group A (XPA) model mice associated with hyperproduction of prostaglandin E2. The Journal of Immunology 166, 5782-5791.

  48. Horiki S., Miyauchi-Hashimoto H., Tanaka K., Nikaido O. and Horio T. (2000) Protecticve effects of sunscreening agents on photocarcinogenesis, photoaging, and DNA damage in XPA gene knockout mice. Arch. Dermatol. Res. 292, 511-518.

  49. Nitta M., Saijo M., Kodo N., Matsuda T., Nakatsu Y., Tamai H. and Tanaka K. (2000) A novel cytoplasmic GTPase XAB1 interacts with DNA repair protein XPA. Nucleic Acid Research 28, 4212-4218.

  50. Nakatsu Y., Asahina H., Citterio E., Rademakers S., Vermeulen W., Kamiuchi S., Yeo J., Khaw M., Saijo M., Kodo N., Matsuda T., Hoeijmakers JHJ. and Tanaka K. (2000) XAB2, a novel tetratricopeptide repeat protein, involved in transcription-coupled DNA repair and transcription. J. Biol. Chem. 275, 34931-34937.

  51. Murai H., Takeuchi S., Nakatsu Y., Ichikawa M., Yoshino M., Gondo Y., Katsuki M. and Tanaka K. (2000) Studies of in vivo mutations in rpsL transgene in UVB-irradiated epidermis of XPA-deficient mice. Mutation Research 450, 181-192.

  52. Ide F., Iida N., Nakatsuru Y., Oda H., Tanaka K. and Ishikawa T. (2000) Mice deficient in the nucleotide excision repair gene XPA have elevated sensitivity to benzo[a]pyrene induction of lung tumors. Carcinogenesis 21, 1263-1265.

  53. Ichikawa M., Nakane H., Marra G., Corti C., Jiricny J., Fitch M., Ford JM., Ikejima M, Shimada T., Yoshino M., Takeuchi S., Nakatsu Y. and Tanaka K. (2000) Decreased UV sensitivity, mismatch repair activity and abnormal cell cycle checkpoints in skin cancer cell lines derived from UVB-irradiated XPA-deficient mice. Mutation Research 459, 285-298.

  54. Kuwamoto K., Miyauchi-Hashimoto H., Tanaka K., Eguchi N., Inui T., Urade Y., Ito S. and Horio T. (2000) Possible involvement of enhanced prostaglandin E2 production in the photosensitivity in xeroderma pigmentosum group A model mice. J. Invest. Dermatol. 114, 241-246.

  55. Imaida K., Ogawa K., Takahashi S., Ito T., Yamaguchi T., Totsuka Y., Wakabayashi K, Tanaka K., Ito N., and Shirai T. (2000) Delay of DNA-adduct repair and severe toxicity in xeroderma pigmentosum group A gene (XPA) deficient mice treated with 2-amino-1-methyl-6-phenyl-imidazo [4,5-b] pyridine. Cancer Lett. 150 (1), 63-69.

  56. Okamoto, H., Mizuno, K., Itoh, T., Tanaka, K., and Horio, T. (1999) Evaluation of apoptotic cells induced by ultraviolet light B radiation in epidermal sheets stained by the TUNEL technique. J. Invest. Dermatol. 113, 802-807.

  57. Miyauchi-Hashimoto, H., Okamoto, H., Tanaka, K., and Horio, T. (1999) Ultraviolet Radiation-induced suppression of natural killer cell activity is enhanced in xeroderma pigmentosum group A (XPA) model mice. J. Invest. Dermatol. 112, 965-970.

  58. Ikegami, T., Kuraoka, I., Saijo, M., Kodo, N., Y. Kyogoku, Morikawa, K., Tanaka, K., and Shirakawa, M. (1999) Resonance assignments, solution structure, and backbone dynamics of the DNA- and RPA-binding domain of human repair factor XPA J. Biochem. 125, 495-506.

  59. Kobayashi, T., Takeuchi, S., Saijo, M., Nakatsu, Y., Morioka, H., Otsuka, E., Wakasugi, M., Nikaido, O., andTanaka, K. (1998) Mutational analysis of a function of xeroderma pigmentosum group A (XPA) protein in strand specific DNA repair. Nucleic Acid Research 26, 4662-4668.

  60. Ikegami, T., Kuraoka, I., Saijo, M., Kodo, N., Y. Kyogoku, Morikawa, K., Tanaka, K., and Shirakawa, M. (1998) Solution structure of the DNA- and RPA-binding domain of the human repair factor XPA. Nature Structural Biology 5, 701-706.

  61. Winter, D. B., Phung, Q. H., Umar, A., Baker, S. M., Tarone, R. E., Tanaka. K., Liskay, R. M., Kunkel, T. A., Bohr, V. A., and Gearhart, P. J. (1998) Altered spectra of hypermutation in antibodies from mice deficient for the DNA mismatch repair protein PMS2. Proc. Natl. Acad. Sci. USA 95, 6953-6958.

  62. Yeo, J. P., Nakatsu, Y., Goldstein, A. M., Tucker, M. A., Kraemer, K. H., and Tanaka, K. (1998) RPA2, A gene for 32 kDa subunit of replication protein A on chromosome 1p35-36, is not mutated in patients with familial melanoma linked to chromosome 1p36. Melanoma Research 8, 47-52.

  63. Takeuchi, S., Nakatsu, Y., Nakane, H., Murai, H., Hirota, S., Kitamura, Y., Okuyama, A., and Tanaka, K. (1998) Strand specificity and absence of hotspots for p53 mutations in UVB-induced skin tumors of XPA-deficient mice. Cancer Research 58, 641-646.

  64. Nocentini, S., Coin, F., Saijo, M., Tanaka, K., and Egly, J-M. (1997) DNA damage recognition by XPA protein promotes efficient recruitment of TFIIH. J. Biol. Chem.,272, 22991-22994.

  65. Enokido, Y. Inamura, N., Toshiyuki, A., Satoh, T., Nakane, H., Yoshino, M. Nakatsu Y., Tanaka, K. and Hatanaka, H. (1997) The xeroderma pigmentosum group A (XPA) gene is involved in UV-induced but not in Low-K+ medium-induced apoptosis of cultured cerebellar neurons. J. Neurochemistry 69, 246-251.

  66. Kobayashi, T., Kuraoka, I., Saijo, M., Nakatsu, Y., Tanaka, A., Someda, Y., Fukuro, S. and Tanaka, K. (1997) Mutations in the XPD gene leading to xeroderma pigmentosum symptoms. Human Mutation 9, 322-331.

  67. Saijo, M., Kuraoka, I., Masutani, C., Hanaoka, F. and Tanaka, K. (1996) Sequential binding of DNA repair proteins RPA and ERCC1 to XPA in vitro. Nucl. Acid Res. 24, 4719-4724.

  68. Miyauchi, H., Tanaka, K. and Horio, T. (1996) Enhanced inflammation and immunosuppression by ultraviolet radiation in xeroderma pigmentosum group A (XPA) model mice. J. Invest. Dermatol. 107, 343-348.

  69. Morita, E. H., Ohkubo, T., Kuraoka, I., Shirakawa, M., Tanaka, K., Morikawa, K. (1996) Implications of the zinc-finger motif found in the DNA-binding domain of the human XPA protein. Genes to Cells 1, 437-442.

  70. Kuraoka, I., Morita, E. H., Saijo, M., Matsuda, T., Morikawa, K., Shirakawa, M. and Tanaka, K. (1996) Identification of a damaged-DNA binding domain of the XPA protein. Mutat. Res. 362, 87-95.

  71. Satokata, I., Uchiyama, M., and Tanaka, K. (1995) Two novel splicing mutations in the XPA gene in patients with group A xeroderma pigmentosum. Human Molecular Genetics 4, 1993-1994.

  72. Shimamoto, T., Tanimura, T., Yoneda, Y., Kobayakawa, Y., Sugasawa, K., Hanaoka, F., Oka, M., Okada, Y., Tanaka, K. and Kohno, K. (1995) Expression and functional analyses of Dxpa gene, the Drosophila homolog of a human excision repair gene XPA. J. Biol. Chem. 270, 22452-22459.

  73. Nakane, H., Takeuchi, H., Yuba, S., Saijo, M., Nakatsu, Y., Murai, H., Nakatsuru, Y., Ishikawa, Hirota, S., Kitamura, Y., Kato, Y., Tsunoda, Y., Miyauchi, H., Horio, T., Tokunaga, T., Matsunaga, T., Nikaido, O., Nishimune, Y., Okada, Y., and Tanaka, K. (1995) High incidence of ultraviolet-B-or chemical-carcinogen-induced skin tumours in mice lacking the xeroderma pigmentosum group A gene. Nature 377, 165-168.

  74. Nagai, A., Saijo, M., Kuraoka, I., Matsuda, T., Kodo, N., Nakatsu, Y., Mimaki, T., Mino, M., Biggerstaff, M., Wood, R. D., Seijbers, A., Hoeijmakers, J. H. J. and Tanaka, K. (1995) Enhancement of the damaged DNA binding activity of XPA by interaction with the ERCC1 DNA repair protein. Biochem. Biophys. Res. Comm. 211, 960-966.

  75. Matsuda, T., Saijo, M., Kuraoka, I., Kobayashi, T., Nakatsu, Y., Nagai, A., Enjoji, T., Masutani, C., Sugasawa, K., Hanaoka, F. Yasui, A. and Tanaka, K. (1995) DNA repair protein XPA binds Replication Protein A. J. Biol. Chem. 270, 4152-4157.

  76. Asahina, H., Kuraoka, I., Shirakawa, M., Eugene H. Morita, Miura, N., Miyamoto, I., Ohtsuka, E., Okada, Y. and Tanaka, K. (1994) The XPA protein is a zinc metalloprotein with an ability to recognize various kinds of DNA damage. Mutat. Res. 315, 229-237.

  77. Tanaka, K. and Wood, R. D. (1994) Xeroderma pigmentosum and nucleotide excision repair of DNA. Trends in Biochemical Sciences 19,107-110.

  78. Satokata, I., Iwai, K., Matsuda, T., Okada, Y. and Tanaka, K. (1993) Genomic characterization of the human DNA excision repair-controlling gene XPAC. Gene 136, 345-348.

  79. Satokata, I., Tanaka, K., Yuba, S. and Okada, Y. (1992) Identification of splicing mutations of the last nucleotides of exons, a nonsense mutation, and a missense mutation of the XPAC gene as causes of group A xeroderma pigmentosum. Mutat. Res. 273, 203-212.

  80. Satokata, I., Tanaka, K., Miura, N., Mimaki, T., Satoh, Y., Kondo, S. and Okada, Y. (1992) Three nonsense mutations responsible for group A xeroderma pigmentosum. Mutat. Res. 273, 193-202.

  81. Satokata, I., Tanaka, K. and Okada, Y. (1992) Molecular basis of group A xeroderma pigmentosum: a missense mutation and two deletions located in a zinc finger consensus sequence of the XPAC gene. Hum. Genet. 88, 603-607.

  82. Miyamoto, I., Miura, N., Niwa, H., Miyazaki, J. and Tanaka, K. (1992) Mutational analysis of the structure and function of the xeroderma pigmentosum group A complementing protein. J. Biol. Chem. 267, 12182-12187.

  83. Shimamoto, T., Kohno, K., Tanaka, K. and Okada, Y. (1991) Molecular cloning of human XPAC gene homologs from chicken, xenopus laevis and drosophila melanogaster. Biochem. Biophys. Res. Comm. 181, 1231-1237.

  84. Miura, N., Miyamoto, I., Asahina, H., Satokata, I., Tanaka., K. and Okada, Y. (1991) Identification and characterization of xpac protein, the gene product of the human XPAC (Xeroderma Pigmentosum Group A Complementing) Gene. J. Biol. Chem. 266, 19786-19789.

  85. Satokata, I., Tanaka, K., Miura, N., Miyamoto, I., Satoh, Y., Kondo, S. and Okada, Y. (1990) Characterization of a splicing mutation in group A xeroderma pigmentosum. Proc. Natl. Acad. Sci. USA 87, 9908-9912.

  86. Tanaka, K., Miura, N., Satokata, I., Miyamoto, I., Yoshida, M. C., Satoh, Y., Kondo, S., Yasui, A., Okayama, H. and Okada, Y. (1990) Analysis of a human DNA excision repair gene involved in group A xeroderma pigmentosum and containing a zinc-finger domain. Nature 348, 73-76.

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