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|
Name |
Email |
Telephone |
| Professor |
YONEDA, Yoshihiro |
 |
+81-6-6879-3211 |
| Associate Professor |
KATAHIRA, Jun |
 |
+81-6-6879-3211 |
| FAX |
+81-6-6879-3219 |
| Postal Mail Address |
Laboratories for Biomolecular
Networks, Department of Frontier Biosciences, Graduate
School of Frontier Biosciences, Osaka University 1-3
Yamadaoka, Suita, Osaka 565-0871 Japan |
In our laboratory, we focus on the nuclear
organization and function in eukaryotic cells. Especially, we
are investigating the molecular mechanism of intracellular signal
transduction via nuclear pores. Our projects are as follows.
| 1 |
Molecular Mechanism
of NucleoCytoplasmic Protein Transport |
| A eukaryotic cell is divided into two major
compartments, nucleus and cytoplasm, by nuclear envelope.
Intracellular signals are transmitted via the continuous
and bi-directional transport of proteins between the
nucleus and the cytoplasm through nuclear pores. To
elucidate the molecular basis for such intracellular
communication, we are investigating the mechanism of
nucleocytoplasmic protein transport. In addition, our
research interests include the regulation mechanism
of the transport in a variety of cells such as cancer
cells and neuronal cells, and intracellular signal
transduction in apoptosis and cell-cell contact. |
| 2 |
Analysis of the Functional
Molecules in Nucleocytoplasmic Transport Mechanism
using the Gene Targeting Approach |
| 3 |
Analysis of Nuclear
Localizing Factor Essential in Apoptosis |
| It is already shown that active nuclear
transport mediated by importin plays essential
roles in apoptosis. We are trying to identify signaling
molecules to trigger nuclear changes during apoptosis. |
| 4 |
Molecular Mechanism
of mRNA Export from the Nucleus |
| 5 |
Post-Transcriptional
mRNA Biogenesis and Gene Expression |
| We are interested in the cellular
and molecular mechanisms underlying the synaptic plasticity
of mammalian brain. On the basis of a hypothesis that
proteins encoded by the mRNAs that are transported
to and translated at the dendrites/synapses may play
key roles in synaptic plasticity, we have identified
a chromodomain-containing nuclear protein, MRG15 as
a novel type of dendritic mRNA in neurons. We will
create transgenic and knockout mice to test the role
of this gene in the process. |
| 7 |
Molecular Mechanisms
of Trafficking and Translational Control of Localized
mRNA in Neuron |
| 8 |
Novel Nano-biotechnology
for in vivo RNA Regulation |
|
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