Japanese Site Map
Message Overview Research Laboratories Events / Publications Admission Access map
Home > Research Laboratories
Biomolecular Networks Laboratories Biomolecular Dynamics Group (Prof. Yoneda)
Nanobiology Laboratories
Soft Biosystem Group
Protonic NanoMachine Group
Sensory Transduction Group

Biomolecular Networks Laboratories
Research Group of Lipid Biosignals
Biomolecular Dynamics Group 
Developmental Biology Group
Chromosome Replication Group

Integrated Biology Laboratories
Laboratory of Genetics
Pathology Division
KOKORO-Biology Group
Cellular Biology Group

Organismal Biosystems Laboratories
Laboratory of Developmental Immunology
Developmental Genetics Group
Human Cell Biology Group
Medicine and Pathophysiology Group

Neuroscience Laboratories
Visual Neuroscience Group
Developmental and Functional Neuroscience Group
Cognitive Neuroscience Group
Cellular and Molecular Neurobiology Group
Synaptic Plasticity Group

Biophysical Dynamics Laboratories
Physiological Laboratory
Nonequilibrium Physics Group
Functional Proteomics Group
Nano-Biophotonics Group

Biomedical Engineering Laboratories
Systems Neuroscience Group
Department of Molecular Genetics
Laboratory of Intercellular Communications
Laboratory of Stem Cell Research
Laboratory of Protein Informatics
Laboratory of Biocatalysis Science

Collaborative institutes
Laboratory of Immune Regulation Chugai Pharmaceutical CO.,LTD.
Optical Nano Device Group
OMRON Corporation

Professor YONEDA, Yoshihiro +81-6-6879-3211
Associate Professor KATAHIRA, Jun +81-6-6879-3211

FAX +81-6-6879-3219
Postal Mail Address Laboratories for Biomolecular Networks, Department of Frontier Biosciences, Graduate School of Frontier Biosciences, Osaka University 1-3 Yamadaoka, Suita, Osaka 565-0871 Japan

In our laboratory, we focus on the nuclear organization and function in eukaryotic cells. Especially, we are investigating the molecular mechanism of intracellular signal transduction via nuclear pores. Our projects are as follows.

1 Molecular Mechanism of NucleoCytoplasmic Protein Transport

A eukaryotic cell is divided into two major compartments, nucleus and cytoplasm, by nuclear envelope. Intracellular signals are transmitted via the continuous and bi-directional transport of proteins between the nucleus and the cytoplasm through nuclear pores. To elucidate the molecular basis for such intracellular communication, we are investigating the mechanism of nucleocytoplasmic protein transport. In addition, our research interests include the regulation mechanism of the transport in a variety of cells such as cancer cells and neuronal cells, and intracellular signal transduction in apoptosis and cell-cell contact.

2 Analysis of the Functional Molecules in Nucleocytoplasmic Transport Mechanism using the Gene Targeting Approach

3 Analysis of Nuclear Localizing Factor Essential in Apoptosis

It is already shown that active nuclear transport mediated by importin plays essential roles in apoptosis. We are trying to identify signaling molecules to trigger nuclear changes during apoptosis.

4 Molecular Mechanism of mRNA Export from the Nucleus

5 Post-Transcriptional mRNA Biogenesis and Gene Expression

We are interested in the cellular and molecular mechanisms underlying the synaptic plasticity of mammalian brain. On the basis of a hypothesis that proteins encoded by the mRNAs that are transported to and translated at the dendrites/synapses may play key roles in synaptic plasticity, we have identified a chromodomain-containing nuclear protein, MRG15 as a novel type of dendritic mRNA in neurons. We will create transgenic and knockout mice to test the role of this gene in the process.
7 Molecular Mechanisms of Trafficking and Translational Control of Localized mRNA in Neuron

8 Novel Nano-biotechnology for in vivo RNA Regulation

Page Top
All rights reserved. Copyright © 2003 Graduate School of Frontier Biosciences, Osaka University