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Name
Email
Telephone
Professor YONEDA, Yoshihiro +81-6-6879-3211
Associate Professor KATAHIRA, Jun +81-6-6879-3211

FAX +81-6-6879-3219
Postal Mail Address Laboratories for Biomolecular Networks, Department of Frontier Biosciences, Graduate School of Frontier Biosciences, Osaka University 1-3 Yamadaoka, Suita, Osaka 565-0871 Japan



In our laboratory, we focus on the nuclear organization and function in eukaryotic cells. Especially, we are investigating the molecular mechanism of intracellular signal transduction via nuclear pores. Our projects are as follows.

1 Molecular Mechanism of NucleoCytoplasmic Protein Transport

A eukaryotic cell is divided into two major compartments, nucleus and cytoplasm, by nuclear envelope. Intracellular signals are transmitted via the continuous and bi-directional transport of proteins between the nucleus and the cytoplasm through nuclear pores. To elucidate the molecular basis for such intracellular communication, we are investigating the mechanism of nucleocytoplasmic protein transport. In addition, our research interests include the regulation mechanism of the transport in a variety of cells such as cancer cells and neuronal cells, and intracellular signal transduction in apoptosis and cell-cell contact.

2 Analysis of the Functional Molecules in Nucleocytoplasmic Transport Mechanism using the Gene Targeting Approach


3 Analysis of Nuclear Localizing Factor Essential in Apoptosis

It is already shown that active nuclear transport mediated by importin plays essential roles in apoptosis. We are trying to identify signaling molecules to trigger nuclear changes during apoptosis.

4 Molecular Mechanism of mRNA Export from the Nucleus


5 Post-Transcriptional mRNA Biogenesis and Gene Expression


6  
We are interested in the cellular and molecular mechanisms underlying the synaptic plasticity of mammalian brain. On the basis of a hypothesis that proteins encoded by the mRNAs that are transported to and translated at the dendrites/synapses may play key roles in synaptic plasticity, we have identified a chromodomain-containing nuclear protein, MRG15 as a novel type of dendritic mRNA in neurons. We will create transgenic and knockout mice to test the role of this gene in the process.
7 Molecular Mechanisms of Trafficking and Translational Control of Localized mRNA in Neuron


8 Novel Nano-biotechnology for in vivo RNA Regulation


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