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Biomolecular Networks Laboratories Developmental Biology Group (Prof. Kondoh)
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Protonic NanoMachine Group
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Biomolecular Networks Laboratories
Research Group of Lipid Biosignals
Biomolecular Dynamics Group
Developmental Biology Group
Chromosome Replication Group

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Synaptic Plasticity Group

Biophysical Dynamics Laboratories
Physiological Laboratory
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Functional Proteomics Group
Nano-Biophotonics Group

Biomedical Engineering Laboratories
Systems Neuroscience Group
Department of Molecular Genetics
Laboratory of Intercellular Communications
Laboratory of Stem Cell Research
Laboratory of Protein Informatics
Laboratory of Biocatalysis Science

Collaborative institutes
Laboratory of Immune Regulation Chugai Pharmaceutical CO.,LTD.
Optical Nano Device Group
OMRON Corporation

Lab. Members

 Nobuhiko Mizuno  Postdoctoral Researcher
 Toshinori Hayashi  Postdoctoral Researcher
 Mitsuji Maruhashi  Graduate Student
 Noriyuki Nishioka  Graduate Student
 Miho Matsumata  Graduate Student
 Hiroki Yoda  Graduate Student
 Shinya Tanaka  Graduate Student
 Tatsuya Takemoto  Graduate Student
 Aki Yoshimoto  Graduate Student
 Tomonori Deguchi  Graduate Student
 Aki Nogimori  Graduate Student
 Tomoya Miyoshi  Graduate Student
 Yoko Ikegami  Technician
 Keiko Nagayama  Secretary


  Publications

  1. Higashi, Y., Moribe, H., Takagi, T., Sekido, R., Kawakami, K., Kikutani, H. and Kondoh, H. (1997) Impairment of T cell development in _EF1 mutant mice. J. Exp. Med. 185, 1467-1479.

  2. Sasaki, H., Hui, C-C., Nakafuku, M. and Kondoh, H. (1997) A binding site for Gli protein is essential for HNF-3b floor plate enhancer activity and is a Shh responsive element. Development 124, 1313-1322.

  3. Wakamatsu, Y., Watanabe, Y., Nakamura, H. and Kondoh, H. (1997) Regulation of the neural crest cell fate by N-myc: promotion of ventral migration and neuronal differentiation. Development 124, 1953-1962.

  4. Sekido, R., Murai, K., Kamachi, Y. and Kondoh, H. (1997) Two mechanisms in the action of repressor _EF1: binding site competition with an activator and active repression. Genes to Cells 2, 771-783.

  5. Takagi, T., Moribe, H., Kondoh, H. and Higashi, Y. (1998) _EF1, a zinc finger and homeodomain-containing factor is required for normal skeleton patterning in multiple lineages. Development 125, 21-32.

  6. Nishiguchi, S., Wood, H., Sockanathan, S., Kondoh, H., Lovell-Badge, R. and Episkopou, V. (1998) Sox1 directly regulates the _-crystallin genes and is essential for lens development in mice. Genes Dev. 12, 776-781.

  7. Kamachi, Y., Uchikawa, M., Collignon, J., Lovell-Badge, R. and Kondoh, H. (1998) Involvement of Sox1, 2 and 3 in the early and subsequent molecular events of lens induction. Development 125, 2521-2532.

  8. Kamachi, Y., Cheah, K.S.E. and Kondoh, H. (1999) Mechanism of regulatory target selection by the SOX High-Mobility-Group domain proteins as revealed by comparison of SOX1/2/3 and SOX9. Mol. Cell. Biol. 19, 107-120.

  9. Shimono, A., Okuda, T. and Kondoh, H. (1999) N-myc-dependent repression of Ndr1, a gene identified by direct subtraction of whole mouse embryo cDNAs between wild type and N-myc mutant. Mech. Dev. 83, 39-52.

  10. Uchikawa, M., Kamachi, Y. and Kondoh, H. (1999) Two distinct subgroups of Group B Sox genes for transcriptional activators and repressors: their expression during embryonic organogenesis of the chicken. Mech. Dev. 84, 103-120.

  11. Sasaki, H., Nishizaki, Y., Hui, C-c., Nakafuku, M. and Kondoh, H. (1999) Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling. Development 126, 3915-3924.

  12. Kondoh, H. (1999) Transcription factors for lens development assessed in vivo. Curr. Opin. Genet. Dev. 9, 301-308.

  13. Furusawa, T., Moribe, H. Kondoh, H. and Higashi, Y. (1999) Identification of CtBP1 and CtBP2 as corepressors of zinc finger-homeodomain factor _EF1. Mol. Cell. Biol.,19, 8581-8590.

  14. Kamachi, Y. Uchikawa, M. and Kondoh, H. (2000) Pairing SOX off with partners in regulation of embryonic development. Trends Genet. 16, 182-187.

  15. Moribe, H., Takagi, T., Kondoh, H. and Higashi, Y. (2000) Genetic interaction of Gli3 and _EF1 in limb skeletal patterning. Dev. Growth Differ. 42, 367-376.

  16. Kondoh, H., Uchikawa, M., Yoda, H., Takeda, H., Furutani-Seiki, M. and Karlstrom, R.O. (2000) Zebrafish mutations in Gli mediated hedgehog signaling lead to lens transdifferentiation from the adenohypophysis anlage. Mech. Dev. 96, 165-174.

  17. Nishizaki, Y., Shimazu, K., Kondoh, H. and Sasaki, H. (2001) Identification of essential sequence motifs in the node/notochord enhancer of Foxa2(Hnf3b) gene that are conserved across vertebrate species. Mech. Dev. 102, 57-66..

  18. Kamachi, Y., Uchikawa, M., Tanouchi, A., Sekido, R, and Kondoh, H. (2001) Pax6 and SOX2 form a co-DNA-binding partner complex that regulates initiation of lens development. Genes Dev. 15, 1272-1286.

  19. Muroyama, Y., Fujihara, M., Ikeya, M., Kondoh, H. and Takada, S. (2002).
    An essential role of Wnt signaling in neuronal specification of the dorsal spinal cord. Genes Dev., in press.

  20. Higashi, Y., Maruhashi, M., Nelles, l., Van de Putte, T., Verschueren, K., Miyoshi, T., Yoshimoto, A., Kondoh, H. and Huylebroeck, D. (2002). Generation of the floxed allele of the SIP1 (Smad-interacting protein 1) gene for the Cre-mediated conditional knockout in the mouse. Genesis, in press.

  21. Zhu, C.C., Dyer, M.A., Uchikawa, M., Kondoh, H., Cepko, C. Lagutin, O.V. and Oliver, G. (2002). Six3-mediated auto-repression and eye development requires its interaction with the Groucho family corepressors. Development, in press.

  22. Kondoh, H. (2002) Lens induction. In Encyclopedia of Life Sciences. Macmillan Reference Ltd (London), in press.

  23. Kondoh, H. (2002) Development of the eye. In "Mouse development: patterning, morphogenesis and organogenesis" (Ed. Rossant, J. and Tam, P), Academic Press, in press.

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