Graduate School of Frontier Biosciences, Osaka University


Laboratory of Stem Cell Biology and Developmental Immunology


* corresponding author

  • Sugiyama, T., *Nagasawa, T.
    CXCL12 catches T-ALL at the entrance of the bone marrow.
    Trends Immunol. 36 (9); 504-506, 2015. Sep "Spotlight" article.
  • *Nagasawa, T.
    CXCL12/SDF-1 and CXCR4.
    Front. Immunol. 6; 301. doi: 10.3389/fimmu.2015.00301. eCollection 2015. Jun 12 Review.
  • Omatsu, Y., *Nagasawa, T.
    The critical and specific transcriptional regulator of the microenvironmental niche for hematopoietic stem and progenitor cells.
    Curr. Opin. Hematol. 22 (4); 330-336, 2015. Jul Review.
  • Sugiyama, T., *Nagasawa, T.
    Myeloid cells stimulate their progenitors in an emergency.
    Immunity 42 (1); 13-14, 2015. Jan 20. "Preview" article.
  • Ono, N., Ono, W., Nagasawa, T., *Kronenberg, H.M.
    A subset of chondrogenic cells provides early mesenchymal progenitors in growing bones.
    Nat. Cell Biol. 16; 1157-1167, 2014. Dec
  • Ono, N., Ono, W., Mizoguchi, T., Nagasawa, T., Frenette, P.S., *Kronenberg, H.M.
    Vasculature-associated cells expressing nestin in developing bones encompass early cells in the osteoblast and endothelial lineage.
    Dev. Cell 29 (3); 330-339, 2014. May 12
  • Omatsu, Y., Seike, M., Sugiyama, T., Kume, T., *Nagasawa, T.
    Foxc1 is a critical regulator of haematopoietic stem/progenitor cell niche formation.
    Nature 508; 536-540, 2014. Apr 24 Epub 2014 Mar 2.
  • *Nagasawa, T.
    CXC chemokine ligand 12 (CXCL12) and its receptor CXCR4.
    J. Mol. Med. 92; 433-439, 2014. May, Epub 2014 Apr 11. Review.
  • Bannard, O., Horton, R.M., Allen, C.D., An, J., Nagasawa, T., *Cyster, J.G.
    Germinal center centroblasts transition to a centrocyte phenotype according to a timed program and depend on the dark zone for effective selection.
    Immunity 39; 912-924, 2013. Nov 14.
  • Nakagawa, R., Togawa, A., Nagasawa, T., *Nishikawa, S.
    Peyer's patch inducer cells play a leading role in the formation of B and T cell zone architecture.
    J. Immunol. 190; 3309-3318, 2013. Apr 1
  • Greenbaum, A., Hsu, Y.M., Day, R.B., Schuettpelz, L.G., Christopher, M.J., Borgerding, J.N., Nagasawa, T., *Link, D.C.
    CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance.
    Nature 495; 227-230, 2013 Mar 14
  • Li, W., Kohara, H., Uchida, Y., James, J.M., Soneji, K., Cronshaw, D.G., Zou, Y.R., Nagasawa, T., *Mukouyama, Y.S.
    Peripheral nerve-derived CXCL12 and VEGF-A regulate the patterning of arterial vessel branching in developing limb skin.
    Dev. Cell 24; 359-371, 2013 Feb 25
  • *Kanatsu-Shinohara, M., Inoue, K., Takashima, S., Takehashi, M., Ogonuki, N., Morimoto, H., Nagasawa, T., Ogura, A., Shinohara, T.
    Reconstitution of mouse spermatogonial stem cell niches in culture.
    Cell Stem Cell 11; 567-578, 2012. Oct 5.
  • Nishiyama, C., Uesaka, T., Manabe, T., Yonekura, Y., Nagasawa, T., Newgreen, D.F., Young, H.M., *Enomoto, H.
    Trans-mesenteric neural crest cells are the principal source of the colonic enteric nervous system.
    Nat. Neurosci. 15; 1211-1218, 2012. Aug 19
  • Noda, M., Omatsu, Y., Sugiyama, T., Oishi, S., Fujii, N., *Nagasawa, T.
    CXCL12-CXCR4 chemokine signaling is essential for NK-cell development in adult mice.
    Blood 117; 451-458, 2011. Jan 13.
  • *Nagasawa, T., Omatsu, Y., Sugiyama, T.
    Control of hematopoietic stem cells by the bone marrow stromal niche: the role of reticular cells.
    Trends Immunol. 32; 315-320, 2011. July, Epub 2011 Apr 29. Review.
  • Sugiyama, T.,*Nagasawa, T.
    Emergency evacuation! Hematopoietic niches induce cell exit in infection.
    Immunity 34; 463-465, 2011. April 22. "Preview" article.
  • Sanematsu, F., Hirashima, M., Laurin, M., Takii, R., Nishikimi, A., Kitajima, K., Ding, G., Noda, M., Murata, Y., Tanaka, Y., Masuko, S., Suda, T., Meno, C., Côté, JF., Nagasawa, T., *Fukui, Y.
    Dock 180 is a rac activator that regulates cardiovascular development by acting downstream of CXCR4.
    Circ. Res. 107; 1102-1105, 2010.
  • Omatsu, Y., Sugiyama, T., Kohara, H., Kondoh, G., Fujii, N., Kohno, K., *Nagasawa, T.
    The essential functions of adipo-osteogenic progenitors as the hematopoietic stem and progenitor cell niche.
    Immunity 33; 387-399, 2010. Sep 24.
  • *Zhu, Y., Matsumoto, T., Mikami, S., Nagasawa, T., *Murakami, F.
    SDF-1/CXCR4 signalling regulates two distinct processes of precerebellar neuron and its deletion leads to abnormal pontine nuclei formation.
    Development 136; 1919-1928, 2009 Jun.
  • *Nagasawa, T.
    New niches for B cell.
    Nat. Immunol. 9 (4); 345-346, 2008. "News and Views" article.
  • Kohara, H., Omatsu, Y., Sugiyama, T., Noda, M., Fujii, N., *Nagasawa, T.
    Development of plasmacytoid dendritic cells in bone marrow stromal cell niches requires CXCL12-CXCR4 chemokine signaling.
    Blood 110; 4153-4160, 2007. Dec 15
  • Sugiyama, T., Kohara, H., Noda, M., *Nagasawa, T.
    Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches.
    Immunity 25; 977-988, 2006. Dec
  • *Nagasawa, T.
    Microenvironmental niches in the bone marrow required for B-cell development.
    Nat. Rev. Immunol. 6 (2); 107-116, 2006. Review.
  • Ara, T., Tokoyoda, K., Okamoto, R., Koni, P.A., and *Nagasawa, T.
    The role of CXCL12 in the organ-specific process of artery formation.
    Blood 105; 3155-3161, 2005. Apr 15
  • Lieberam, I., Agalliu/ D., Nagasawa, T., Ericson, J., *Jessell, T.M.
    A CXCL12-CXCR4 chemokine signaling pathway defines the initial trajectory of Mammalian motor axons.
    Neuron 47; 667-679, 2005. Sep 1
  • Tokoyoda, K., Egawa, T., Sugiyama, T., Choi, B.I., *Nagasawa, T.
    Cellular niches controlling B lymphocyte behavior within bone marrow during development.
    Immunity 20; 707-718, 2004. Jun
  • Ara, T., Nakamura, Y., Egawa, T., Sugiyama, T., Abe, K., Kishimoto, T., Matsui, Y., *Nagasawa, T.
    Impaired colonization of the gonads by primordial germ cells in mice lacking a chemokine, stromal cell-derived factor (SDF-1)
    Proc. Natl. Acad. Sci. USA. 100; 5319-5323, 2003
  • Ara, T., Itoi M., Kawabata, K., Egawa, T., Tokoyoda, K., Sugiyama, T., Fujii, N., Amagai, T., *Nagasawa, T.
    A role of CXCL12/SDF-1/PBSF and its receptor CXCR4 in fetal and adult T cell development in vivo
    J. Immunol. 170; 4649-4655, 2003
  • Stumm, R., Zhou, C., Ara, T., Lazarini, F, Dubois-Dalcq, M., Nagasawa, T., Hollt, V., *Schulz, S.
    CXCR4 regulates interneuron migration in the developing neocortex.
    J. Neurosci. 23; 5123-5130, 2003
  • Ara, T., Tokoyoda, K., Sugiyama, T., Egawa, T., Kawabata, K., *Nagasawa, T.
    Long-term hematopoietic stem cells require stromal cell-derived factor-1 for colonizing bone marrow during ontogeny.
    Immunity 19; 257-267, 2003 (cover photo). Aug
  • Egawa, T., Kawabata, K., Kawamoto, H., Amada, K., Okamoto, R., Fujii, N., Kishimoto, T., Katsura, Y., *Nagasawa, T.
    The earliest stages of B cell development require a chemokine stromal cell-derived factor / pre-B cell growth-stimulating factor.
    Immunity 15; 323-334, 2001. Aug
  • Kawabata, K., Ujikawa, M., Egawa, T., Kawamoto, H., Tachibana, K., Iizasa, H., Katsura, Y., Kishimoto, T., *Nagasawa, T.
    A cell-autonomous requirement for CXCR4 in long-term lymphoid and myeloid reconstitution.
    Proc. Natl. Acad. Sci. USA. 96; 5663-5667, 1999.
  • Tachibana, K., Hirota, S., Iizasa, H., Yoshida, H., Kawabata, K., Kataoka, Y., Kitamura, Y., Matsushima, K., Yoshida, N., Nishikawa, S., Kishimoto, T., *Nagasawa, T.
    The chomokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract.
    Nature 393 (6685); 591-594, 1998. Jun 11
  • Tachibana, K., Nakajima, T., Sato, A., Igarashi, K., Shida, H., Iizasa, H., Yoshida, N., Yoshie, O., Kishimoto, T., *Nagasawa, T.
    CXCR4/fusin is not a species-specific barrier in murine cells for HIV-1 entry.
    J. Exp. Med. 186; 1389-1393, 1997.
  • Murakami, T., Nakajima, T., Koyanagi, Y., Tachibana, K., Fujii, N., Tamamura, H., Yoshida, N., Waki, M., Matsumoto, A., Yoshie, O., Kishimoto, T., Yamamoto, N., *Nagasawa, T.
    A small molecule CXCR4 inhibitor that blocks T cell line-tropic HIV-1 infection.
    J. Exp. Med. 186; 1389-1393, 1997.
  • *Nagasawa, T., Hirota, S., Tachibana, K., Takakura, N., Nishikawa, S.-I., Kitamura, Y.,Yoshida, N., Kikutani, H., Kishimoto, T.
    Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1.
    Nature 382 (6592); 635-638, 1996. Aug 15
  • Nagasawa, T., Nakajima, T., Tachibana, K., Iizasa, H., Bleul, C. C., Yoshie, O., Matsushima, K., Yoshida, N., Springer, T. A., Kishimoto, T.
    Molecular cloning and characterization of a murine pre-B-cell growth-stimulating factor/stromal cell-derived factor 1 receptor, a murine homolog of the human immunodeficiency virus 1 entry coreceptor fusin.
    Proc. Natl. Acad. Sci. USA. 93; 14726-14729, 1996.
  • Nagasawa, T., Kikutani, H., Kishimoto, T.
    Molecular cloning and structure of a pre-B-cell growth-stimulating factor.
    Proc. Natl. Acad. Sci. USA. 91 (6); 2305-2309, 1994. Dec