Graduate School of Frontier Biosciences, Osaka University


Nuclear Dynamics Group


Original Papers

  1. Tashiro S, Handa T,Matsuda A, Ban T, Takigawa T, Miyasato K, Ishii K, Kazuto Kugou K, Kunihiro Ohta K, Hiraoka Y, Masukata H, Kanoh J(2016) Shugoshin forms a specialized chromatin domain at subtelomeres that regulates transcription and replication timing. Nat. Commun., Jan 2015, 7:10393, doi:10.1038/ncomms10393(open-access)
  2. Asakawa H, Yang HJ, Hiraoka Y, Haraguchi T (2016) Virtual nuclear envelope breakdown and its regulators in fission yeast meiosis. Front. Cell Dev. Biol., Jan 15, 4:5, doi: 10.3389/fcell.2016.00005
  3. Yang HJ, Haraguchi T, Hiraoka Y(2016) A nucleoporin that facilitates meiotic kinetochore reorganization. Cell Cycle., Jan 4, 0, doi: 10.1080/15384101.2015.1125237

  1. Ohtsuki T, Miki S, Kobayashi S, Haraguchi T, Nakata E, Hirakawa K, Sumita K, Watanabe K, Okazaki S.(2015) The molecular mechanism of photochemical internalization of cell penetrating peptide-cargo-photosensitizer conjugates. Sci Rep., Dec 21, 5:18577, doi: 10.1038/srep18577
  2. Yamamoto J, Oura M, Yamashita T, Miki S, Jin T, Haraguchi T, Hiraoka Y, Terai H, Kinjo M (2015) Rotational diffusion measurements using polarization-dependent fluorescence correlation spectroscopy based on superconducting nanowire single-photon detector. Opt. Express., Dec 10, 23(25):32633-32642, doi: 10.1364/OE.23.032633
  3. Ding DQ, Matsuda A, Okamasa K, Nagahama Y, Haraguchi T, Hiraoka Y (2015) Meiotic cohesin-based chromosome structure is essential for homologous chromosome pairing in Schizosaccharomyces pombeChromosoma, Advanced Online publication Oct 28, doi:10.1007/s00412-015-0551-8
  4. Chikashige Y, Arakawa S, Leibnitz K, Tsutsumi C, Mori C, Osakada H, Murata M, Haraguchi T, Hiraoka Y (2015) Cellular economy in fission yeast cells continuously cultured with limited nitrogen resources. Sci. Rep., Oct 21, 5:15617, doi:10.1038/srep15617
  5. Yang HJ, Asakawa H, Haraguchi T,  Hiraoka Y. (2015) Nup132 modulates meiotic spindle attachment in fission yeast by regulating kinetochore assembly. J. Cell Biol., Oct 26, 211(2):295-308, doi: 10.1083/jcb.201501035
  6. Asakawa H, Yamamoto T. G, Hiraoka Y. (2015) Fission yeast meets a legend in Kobe: report of the Eighth International Fission Yeast Meeting. Genes Cells., Article first published online: 19 Oct, 20:967-971, doi:10.1111/gtc.12307
  7. Tsuchiya M, Isogai S, Taniguchi H, Tochio H, Shirakawa M, Morohashi K, Hiraoka Y, Haraguchi T, Ogawa H. (2015) Selective autophagic receptor p62 regulates the abundance of transcriptional coregulator ARIP4 during nutrient starvation. Sci. Rep., Sep 28, 5:14498, doi: 10.1038/srep14498(open-access)
  8. Iwamoto M, Hiraoka Y, Haraguchi H. The nuclear pore complex acts as a master switch for nuclear and cell differentiation. Commun. Integr. Biol., Aug 31, 8(4): e1056950, doi:10.1080/19420889.2015.1056950
  9. Ruan K, Yamamoto TG, Asakawa H, Chikashige Y, Kimura H, Masukata H, Haraguchi T, Hiraoka Y. (2015) Histone H4 acetylation required for chromatin decompaction during DNA replication. Sci. Rep., July 30, 5:12720, doi:10.1038/srep12720(open-access)
  10. Matsuda A, Chikashige Y, Ding DQ, Ohtsuki C, Mori C, Asakawa H, Kimura H, Haraguchi T, Hiraoka Y. (2015) Highly condensed chromatins are formed adjacent to subtelomeric and decondensed silent chromatin in fission yeast. Nat. Commun., Jul 24, 6:7753, doi: 10.1038/ncomms8753 (open-access)
  11. Poonperm R, Takata H, Hamano T, Matsuda A, Uchiyama S, Hiraoka Y, Fukui K. (2015) Chromosome Scaffold is a Double-Stranded Assembly of Scaffold Proteins. Sci. Rep., Jul 1, 5:11916, doi: 10.1038/srep11916(open-access)
  12. Hirano Y, Matsuda A, Hiraoka Y. (2015) Recent advancements in structured-illumination microscopy toward live-cell imaging. Microscopy (Oxf)., Aug, 64(4):237-249, doi: 10.1093/jmicro/dfv034, Epub 2015 Jun 30.
  13. Asakawa H, Mori C, Ohtsuki C, Iwamoto M, Hiraoka Y, Haraguchi T. (2015) Uncleavable Nup98-Nup96 is functional in fission yeast. FEBS Open Bio., Jun 12, 5:508-514, doi: 10.1016/j.fob.2015.06.004. eCollection 2015(open-access)
  14. Kobayashi S, Koujin T, Kojidani T, Osakada H, Mori C, Hiraoka Y, Haraguchi T, (2015) BAF is a cytosolic DNA sensor that leads to exogenous DNA avoiding autophagy. Proc. Nat.l Acad. Sci. USA, Jun 2, 112(22):7027-7032, doi: 10.1073/pnas.1501235112, Epub 2015 May 19.(open-access)
  15. Iwamoto M, Koujin T, Osakada H, Mori C, Kojidani T, Matsuda A, Asakawa H, Hiraoka Y, Haraguchi T. (2015) Biased assembly of the nuclear pore complex is required for somatic and germline nuclear differentiation in TetrahymenaJ. Cell Sci., Advance Online Article March 18, 128(9):1812-1823, doi:10.1242/jcs.167353(open-access)
  16. Ozaki K, Chikashige Y, Hiraoka Y, Matsumoto T. (2015) Fission Yeast Scp3 Potentially Maintains Microtubule Orientation through Bundling. PLoS One., Mar 13, 10(3):e0120109. doi: 10.1371/journal.pone.0120109 (open-access)
  17. Liu NA, Sun J, Kono K, Horikoshi Y, Ikura T, Tong X, Haraguchi T, Tashiro S.(2015) Regulation of homologous recombinational repair by lamin B1 in radiation-induced DNA damage. FASEB J., Jun, 29(6):2514-25, doi: 10.1096/fj.14-265546, Epub 2015 Mar 2.
  18. Ruan K, Yamamoto TG, Asakawa H, Chikashige Y, Masukata H, Haraguchi T,Hiraoka Y. (2015) Meiotic nuclear movements in fission yeast are regulated by the transcription factor Mei4 downstream of a Cds1-dependent replication checkpoint pathway. Genes Cells., 20:160-172, Epub Dec 10, doi: 10.1111/gtc.12207(open-access)
  19. Haraguchi T, Osakada H, Koujin T. (2015) Live CLEM Imaging to Analyze Nuclear Structures at High Resolution. Methods Mol. Biol., 1262:89-103. doi: 10.1007/978-1-4939-2253-6_6

  1. Nakano T, Kobayashi S, Suda T, Okaie Y, Hiraoka Y, Haraguchi T.(2014) Externally Controllable Molecular Communication Systems. IEEE Journal of Selected Areas in Communications, Vol 32, No 12, pp2417-2431. (open-access)
  2. Yamashita T, Liu D, Miki S,  Yamamoto J, Haraguchi T, Kinjo M, Hiraoka Y, Wang Z, Terai H.(2014) Fluorescence correlation spectroscopy with visible-wavelength superconducting nanowire single-photon detector. Opt. Express, 22(23): 28783-28789.
  3. Nakano T, Kobayashi S, Suda T, Okaie Y, Hiraoka Y, Haraguchi T.(2014) Externally Controllable Molecular Communication Systems for Pattern Formation. ACM NANOCOM 2014 Proceedings, No. 14, doi:10.1145/2619955.2619971
  4. Chikashige Y, Yamane M, Okamasa K, Mori C, Fukuta N, Matsuda A, Haraguchi T, Hiraoka Y.(2014) Chromosomes rein back the spindle pole body during horsetail movement in fission yeast meiosis. Cell Struct. Funct. 39: 93-100.  Epub 2014 Jun 20. (open-access)
  5. Kuramoto K, Sakai F, Yoshinori N, Nakamura TY, Wakabayashi S, Kojidani T, Haraguchi T, Hirose F, Osumi T.(2014) Deficiency of a lipid droplet protein, Perilipin 5, suppresses myocardial lipid accumulation, thereby preventing type 1 diabetes-induced heart malfunction. Mol. Cell Biol. 34 (14): 2721-2731. May 12. [Epub ahead of print]
  6. Asakawa H, Yang HJ, Yamamoto TG, Ohtsuki C, Chikashige Y, Sakata-Sogawa K, Tokunaga M, Iwamoto M, Hiraoka Y, Haraguchi T. (2014) Characterization of nuclear pore complex components in fission yeast Schizosaccharomyces pombe. Nucleus. 5(2):149-162. doi: 10.4161/nucl.28487(open-access)
  7. Asakawa H, Hiraoka Y, Haraguchi T. (2014) A method of correlative light and electron microcopy for yeast cells. Micron, 61: 53-61.
  8. Oana H, Nishikawa K, Matsuhara H, Yamamoto A, Yamamoto TG, Haraguchi T, Hiraoka Y, Washizu M. (2014) Non-destructive handling of individual chromatin fibers isolated from single cells in a microfluidic device utilizing an optically driven microtool. Lab on a Chip. 14 (4): 696-704.

  1. Miyabayashi K, Katoh-Fukui Y, Ogawa H, Baba T, Shima Y, Sugiyama N, Kitamura K, Morohashi K. (2013) Aristaless related homeobox gene, Arx, is implicated in mouse fetal Leydig cell differentiation possibly through expressing in the progenitor cells. PLoS One, Jun 28;8(6):e68050. doi: 10.1371/journal.pone.0068050.
  2. Iwamoto M, Mori C, Hiraoka Y, Haraguchi T (2013) Puromycin resistance gene as an effective selection marker for ciliate TetrahymenaGene 534: 249-255.
  3. Ding DQ, Haraguchi T, Hiraoka Y.(2013) The role of chromosomal retention of noncoding RNA in meiosis. Chromosome Res. Dec;21(6-7):665-672. doi: 10.1007/s10577-013-9389-1.
  4. Fujita N, Morita E, Itoh T, Tanaka A, Nakaoka M, Osada Y, Umemoto T, Saitoh T, Nakatogawa H, Kobayashi S, Haraguchi T, Guan J-L, Iwai K, Tokunaga F, Saito K,  Ishibashi K, Akira S, Fukuda M, Noda T, Yoshimori T. (2013) Recruitment of the autophagic machinery to endosomes during infection is mediated by ubiquitin. J. Cell Biol., 203(1): 115-128. jcb.201304188. Published October 7, 2013, doi:10.1083/jcb.201304188
  5. Tadashi Nakano, Andrew W. Eckford, Tokuko Haraguchi  (2013) Molecular Communication Cambridge University Press,  2013 Sep. 12
  6. Oya E, Kato H, Chikashige Y, Tsutsumi C, Hiraoka Y, Murakami Y. (2013) Mediator Directs Co-transcriptional Heterochromatin Assembly by RNA Interference-Dependent and -Independent Pathways. PLoS Genet., Aug;9(8):e1003677. doi: 10.1371/journal.pgen.1003677. Epub 2013 Aug 15.(open-access)
  7. Sato Y, Mukai M, Ueda J, Muraki M, Stasevich TJ, Horikoshi N, Kujirai T, Kita H, Kimura T, Hira S, Okada Y, Hayashi-Takanaka Y, Obuse C, Kurumizaka H, Kawahara A, Yamagata K, Nozaki N, and Kimura H. (2013) Genetically encoded system to track histone modification in vivo. Sci. Rep. 3;2436.
  8. Sadaie M, Salma R, Carroll T, Tomimatsu K, Chandra T, Young AR, Narita M, Pérez-Mancera, Bennett DC, Chong H, Kimura H, and Narita M. (2013) Uneven alterations in the lamin B1 genomic profile regulate heterochromatin formation and gene expression during senescence. Genes Dev. 27, 1800-1808.
  9. Dinant C, Ampatziadis-Michailidis G, Lans H, Tresini M, Lagarou A, Grosbart M, Theil A, van Cappellen WA, Kimura H, Bartek J, Fousteri M, Houtsmuller AB, Vermeulen W, and Marteijn JA. (2013) Enhanced chromatin dynamics by FACT promotes transcriptional restart after UV-induced DNA damage. Mol. Cell 51, 469-479.
  10. Eberhart A, Feodorova Y, Song C, Wanner G, Kiseleva E, Furukawa T, Kimura H, Schotta G, Leonhardt H, Joffe B, and Solovei I. (2013) Epigenetics of eu- and heterochromatin in inverted and conventional nuclei from mouse retina. Chromosome Res. 21, 535-554.
  11. Muramatsu D, Singh PB, Kimura H, Tachibana M, and Shinkai Y. (2013) Pericentric heterochromatin generated by HP1 interaction-defective histone methyltransferase Suv39h1. J. Biol. Chem. 288, 25285-25296.
  12. Yokoyama Y, Hieda M, Nishioka Y, Matsumoto A, Higashi S, Kimura H, Yamamoto H, Mori M, Matsuura S, and Matsuura N. (2013) Cancer associated up-regulation of H3K9 trimethylation promotes cell motility in vitro and drives tumor formation in vivo. Cancer Sci 104, 889-895. Kimura H. Histone modifications for human epigenome analysis. J. Hum. Genet. 58, 439-445.
  13. Nozawa RS, Nagao K, Igami K, Shibata S, Shirai N, Nozaki N, Sado T, Kimura H, and Obuse C. (2013) Human inactive X chromosome is compacted through a PRC2-independent SMCHD1-HBiX1 pathway. Nat. Struct. Mol. Biol. 20, 566-573.
  14. Iwamoto M, Asakawa H, Ohtsuki C, Osakada H, Koujin T, Hiraoka Y, Haraguchi T. (2013) Monoclonal Antibodies Recognize Gly-Leu-Phe-Gly Repeat of Nucleoporin Nup98 of Tetrahymena, Yeasts and Humans. Monoclonal Antibodies in Immunodiagnosis and Immunotherapy, 32(2): 81-90., Selected for "Highlighted Articles"
  15. Haraguchi T. (2013) 13C2 Anti-Nup98 Monoclonal Antibodies in Immunodiagnosis and Immunotherapy, 32(2): 141-141.
  16. Haraguchi T. (2013) 21A10 Anti-Nup98 Monoclonal Antibodies in Immunodiagnosis and Immunotherapy, 32(2): 142-142.
  17. Hamasaki M, Furuta N, Matsuda A, Nezu A, Yamamoto A, Fujita N, Oomori H, Noda T, Haraguchi T, Hiraoka Y, Amano A, Yoshimori T.(2013) Autophagosomes form at ER-mitochondria contact sites. Nature 495, 389-393.
  18. Yoshida M, Katsuyama S, Tateho K, Nakamura H, Miyoshi J, Ohba T, Matsuhara H, Miki F, Okazaki K, Haraguchi T, Niwa O, Hiraoka Y, Yamamoto A. (2013) Microtubule-organizing center formation at telomeres induces meiotic telomere clustering. J. Cell Biol., 200(4): 385-395.
  19. Ichikawa Y, Kagawa W, Saito K, Chikashige Y, Haraguchi T, Hiraoka Y, Kurumizaka H. (2013) Purification and characterization of the fission yeast telomere clustering factors, Bqt1 and Bqt2. Protein Expr Purif., 88(2): 207-213.

  1. Ding, D.-Q., Haraguchi, T., Hiraoka, Y.(2012) Chromosomally-retained RNA mediates homologous pairing. Nucleus, 3(6): 516-519.
  2. Hashimoto T, Segawa H, Okuno M, Kano H, Hamaguchi HO, Haraguchi T, Hiraoka Y, Hasui S, Yamaguchi T, Hirose F, Osumi T.(2012) Active involvement of micro-lipid droplets and lipid droplet-associated proteins in hormone-stimulated lipolysis in adipocytes. J. Cell Sci. 125(24):6127-36.
  3. Asakawa H, Hiraoka Y, Haraguchi T.(2012) Live CLEM imaging: an application for yeast cells In "Current microscopy contributions to advances in science and technology", vol. 1; 478-485. A. Méndez-Vilas (Ed.)
  4. Hirano Y, Hizume K, Kimura H, Takeyasu K, Haraguchi T, Hiraoka Y.(2012) Lamin B receptor recognizes specific modification of histone H4 in heterochromatin formation. J. Biol. Chem. , 287(51): 42654-42663.
  5. Fujita I, Nishihara Y, Tanaka M, Tsujii H, Chikashige Y, Watanabe Y, Saito M, Ishikawa F, Hiraoka Y, Kanoh J.(2012). Telomere-Nuclear Envelope Dissociation Promoted by Rap1 Phosphorylation Ensures Faithful Chromosome Segregation. Curr. Biol., 22, 1932-1937.
  6. Vielle A, Lang J, Dong Y, Ercan S, Kotwaliwale C, Rechtsteiner A, Appert A, Chen QB, Dose A, Egelhofer T, Kimura H, Stempor P, Dernburg A, Lieb JD, Strome S, and Ahringer J. (2012).  H4K20me1 Contributes to Downregulation of X-Linked Genes for C. elegans Dosage Compensation. PLoS Genet. 8, e1002933.
  7. Karmodiya K, Krebs AR, Oulad-Abdelghani M, Kimura H, and Tora L. (2012).  H3K9 and H3K14 acetylation co-occur at many gene regulatory elements, while H3K14ac marks a subset of inactive inducible promoters in mouse embryonic stem cells. BMC Genomics 13, 424.
  8. Sato K, Ishiai M, Toda K, Furukoshi S, Osakabe A, Tachiwana H, Takizawa Y, Kagawa W, Kitao H, Dohmae N, Obuse C, Kimura H, *Takata M, and Kurumizaka H. (2012). Histone chaperone activity of Fanconi anemia proteins, FANCD2 and FANCI, is required for DNA crosslink repair. EMBO J. 31, 3524-3536.
  9. Chandra T, Kirschner K, Thuret JY, Pope BD, Ryba T, Newman S, Ahmed K, Samarajiwa SA, Salama R, Carroll T, Stark R, Janky R, Narita M, Xue L, Chicas A, Nũnez S, Janknecht R, Hayashi-Takanaka Y, Wilson MD, Marshall A, Odom DT, Babu MM, Bazett-Jones DP, Tavaré S, Edwards PA, Lowe SW, Kimura H, Gilbert DM, and Narita M. (2012). Independence of repressive histone marks and chromatin compaction during senescent heterochromatic layer formation. Mol. Cell 47, 203-214.
  10. Katayama T, Kobayashi H, Okamura T, Yamasaki-Katayama Y, Kibayashi T, Kimura H, Ohsawa K, Kohsaka S, and Minami M. (2012).  Accumulating Microglia Phagocytose Injured Neurons in Hippocampal Slice Cultures: Involvement of p38 MAP Kinase. PLoS One 7, e40813.
  11. Kim J-M, To TK, Ishida J, Matsui A, Kimura H, Seki M. (2012). Transition of Chromatin Status During The Recovery Process from Drought Stress in Arabidopsis thalianaPlant Cell Physiol. 53, 847-856.
  12. Ohzeki J-i, Bergmann JH, Kouprina N, Noskov VN, Nakano M, Kimura H, Earnshaw WC, Larionov V, and Masumoto H. (2012). Breaking the HAC Barrier: Histone H3K9 acetyl/methyl balance regulates CENP-A assembly. EMBO J. 31, 2391-2402.
  13. Tange Y, Kurabayashi A, Goto B, Hoe K-L, Kim D-U, Park H-O, Hayles J, Chikashige Y,Tsutumi C, Hiraoka Y, Yamao F, Nurse P, and Niwa O.(2012) The CCR4-NOT Complex Is Implicated in the Viability of Aneuploid Yeasts. PLoS Genetics, Jun;8(6):e1002776. Epub 2012 Jun 21.
  14. Ding DQ , Okamasa K, Yamane M, Tsutsumi C, Haraguchi T, Yamamoto M, and Hiraoka Y. (2012)  Meiosis-specific non-coding RNA mediates robust pairing of homologous chromosomes in meiosis. Science, 336(6082): 732-736.
  15. Ushijima Y, Inoue YH, Konishi T, Kitazawa D, Yoshida H, Shimaji K, Kimura H, and Yamaguchi M. (2012) Roles of histone H3K9 methyltransferases during Drosophila spermatogenesis. Chromosome Res. 20, 319-331.
  16. Yamashita A, Shichino Y, Tanaka H, Hiriart E, Touat-Todeschini L, Vavasseur A, Ding DQ, Hiraoka Y, Verdel A, and Yamamoto M. (2012) Hexanucleotide motifs mediate recruitment of the RNA elimination machinery to silent meiotic genes. Open Biology, Mar 21; 2:120014
  17. Kobayashi S, Hattori Y, Osakada H, Toma K, Maitani Y, Hiraoka Y, Haraguchi T. (2012) Early entry and deformation of macropinosomes correlates with high efficiency of decaarginine-PEG-lipid-mediated gene delivery. J. Gene Med. 14, 262-271. 
  18. Hirose H, Takeuchi T, Osakada H, Pujals S, Katayama S, Nakase I, Kobayashi S, Haraguchi T, Futaki S. (2012) Transient Focal Membrane Deformation Induced by Arginine-rich Peptides Leads to Their Direct Penetration into Cells. Mol. Ther. 20(5), 984-993. 
  19. Yamagata K, Iwamoto D, Terashita Y, Li C, Wakayama S, Hayashi-Takanaka Y, Kimura H, Saeki K, and Wakayama T. (2012) Fluorescence Cell Imaging and Manipulation Using Conventional Halogen Lamp Microscopy. PLoS ONE 7, e31638.
  20. Bergmann JH, Jakubsche JN, Martins NM, Kagansky A, Nakano M, Kimura H, Kelly DA, Turner BM, Masumoto H, Larionov V, and Earnshaw WC. (2012) Epigenetic Engineering: Histone H3K9 acetylation is compatible with kinetochore structure and function. J. Cell Sci. 125, 411-421.
  21. Brookes E, de Santiago I, Hebenstreit D, Morris KJ, Carroll T, Xie SQ, Stock JK, Heidemann M, Eick D, Nozaki N, Kimura H, Ragoussis J, Teichmann SA, and Pombo A. (2012) Polycomb Associates Genome-wide with a Specific RNA Polymerase II Variant, and Regulates Metabolic Genes in ESCs. Cell Stem Cell 10, 157-170.
  22. Iimori M, Ozaki K, Chikashige Y, Habu T, Hiraoka Y, Maki T, Hayashi I, Obuse C, Matsumoto T. (2012) A mutation of the fission yeast EB1 overcomes negative regulation by phosphorylation and stabilizes microtubules. Exp. Cell Res. 2012 Feb 1; 318(3): 262-275.

  1. Asakawa H, Hiraoka Y, Haraguchi T. (2011) Physical breakdown of the nuclear envelope is not necessary for breaking its barrier function. Nucleus, Dec.; 2(6): 523-526.
  2. Tsuchiya M, Ogawa H, Suzuki T, Sugiyama N, Haraguchi T Hiraoka Y. (2011) Exportin 4 interacts with Sox9 through the HMG box and inhibits the DNA binding of Sox9. PLoS ONE 6(10):e25694
  3. Hagiwara A, Tanaka Y, Hikawa R, Morone N, Kusumi A, Kimura H, and Kinoshita M. (2011) Submembranous septins as relatively stable components of actin-based membrane skeleton. Cytoskeleton 68, 512-525.
  4. Tachiwana H, Kagawa W, Shiga T, Osakabe A, Miya Y, Saito K, Hayashi-Takanaka Y, Oda T, Sato M, Park SY, Kimura H, and Kurumizaka H. (2011) Crystal structure of the human centromeric nucleosome containing CENP-A. Nature 476: 232-235.
  5. Hiraoka Y, Maekawa H, Asakawa H, Chikashige Y, Kojidani T, Osakada H, Matsuda A, Haraguchi T. (2011) Inner nuclear membrane protein Ima1 is dispensable for intranuclear positioning of centromeres. Genes Cells, Oct.; 16(10):1000-1011. Sep 1. [Epub ahead of print]
  6. Sheltzer JM, Blank HM, Pfau SJ, Tange Y, George BM, Humpton TJ, BritoIL, Hiraoka Y, Niwa O, Amon A. (2011) Aneuploidy drives genomic instability in yeast. Science Aug 19; 333(6045):1026-30.
  7. Asakawa H, Hiraoka Y, Haraguchi T. (2011) Nuclear translocation of RanGAP1 coincides with virtual nuclear envelope breakdown in fission yeast meiosis. Commun. Integr. Biol. 4(3):312-314.
  8. Hayashi-Takanaka Y, Yamagata K, Wakayama T, Stasevich TJ, Kainuma T, Tsurimoto T, Tachibana M, Shinkai Y, Kurumizaka H, Nozaki N, and Kimura H. (2011) Tracking epigenetic histone modifications in single cells using Fab-based live endogenous modification labeling. Nucleic Acids Res. 3: 6475-6488. Selected as "Featured Article(top 5%)", Selected as "news" by
  9. Tachiwana H, Osakabe A, Shiga T, Miya Y, Kimura H, Kagawa W, and Kurumizaka H. (2011) Crystal structures of human nucleosomes containing major histone H3 variants. Acta Crystallographica section D Biol Crystallogr 67: 578-583.
  10. To TK, Kim JM, Matsui A, Kurihara Y, Morosawa T, Ishida J, Tanaka M, Endo T, Kakutani T, Toyoda T, Kimura H, Yokoyama S, Shinozaki K, Seki M. (2011) Arabidopsis HDA6 regulates locus-directed heterochromatin silencing in cooperation with MET1. PLoS Genet. 7, e1002055.
  11. Yamazaki, Y, Tokumasu, R, Kimura, H, and Tsukita, S. (2011) Role of claudin-species specific dynamics in reconstitution and remodeling of the zonula occludens. Mol. Biol. Cell 22: 1495-1504.
  12. Kondo T, Hamao K, Kamijo K, Kimura H, Morita M, Hosoya H. (2011) Enhancement of myosin II / actin turnover at the contractile ring induces slower furrowing in dividing HeLa cells. Biochem. J. 435: 569-76.
  13. Liu T, Rechtsteiner A, Egelhofer TA, Vielle A, Latorre I, Cheung MS, Ercan S, Ikegami K, Jensen M, Kolasinska-Zwierz P, Rosenbaum H, Shin H, Taing S, Takasaki T, Iniguez AL, Desai A, Dernburg AF, Kimura H, Lieb JD, Ahringer J, Strome S, Liu XS. (2011) Broad chromosomal domains of histone modification patterns in C. elegansGenome Res. 21: 227-36.
  14. Bergmann JH, Rodríguez MG, Martins NM, Kimura H, Kelly DA, Masumoto H, Larionov V, Jansen LE, Earnshaw WC. (2011) Epigenetic engineering shows H3K4me2 is required for HJURP targeting and CENP-A assembly on a synthetic human kinetochore. EMBO J. 30: 328-340.
  15. Osborne EA, Hiraoka Y, Rine J.(2011) Symmetry, asymmetry, and kinetics of silencing establishment in Saccharomyces cerevisiae revealed by single-cell optical assays. Proc Natl Acad Sci U S A. 25;108(4): 1209-16.
  16. Chen Y, Rai R, Zhou ZR, Kanoh J, Ribeyre C, Yang Y, Zheng H, Damay P, Wang F, Tsujii H, Hiraoka Y, Shore D, Hu HY, Chang S, Lei M. (2011)  A conserved motif within RAP1 has diversified roles in telomere protection and regulation in different organisms. Nat. Struct. Mol. Biol. 18: 213-21.
  17. Masuda H, Fong CS, Ohtsuki C, Haraguchi H, Hiraoka Y. (2011) Spatio-temporal regulations of Wee1 at the G2-M transition. Mol. Biol. Cell 22: 555-569. Selected as "Journal Cover", Selected as "A Highlights from MBoC Selection"

  1. Tamura K, Fukao Y, Iwamoto M, Haraguchi T, Hara-Nishimura I. (2010) Comprehensive Identification of Nuclear Pore Complex Components in Arabidopsis thalianaPlant Cell, E-publication ahead, Introduced in"In Brief", the Plant Cell, Selected by a member of "the Faculty of 1000"
  2. Asakawa H., Kojidani T,. Mori, C., Osakada H., Sato M., Ding D.-Q. Hiraoka Y., Haraguchi, T (2010) Virtual breakdown of the nuclear envelope in fission yeast meiosis. Curr. Biol. 20: 1919-1925.
  3. Chikashige Y, Haraguchi T, Hiraoka Y. (2010) Nuclear envelope attachment is not necessary for telomere function in fission yeast. Nucleus, 1: 481-486.
  4. Ito, S., Tan L.-J., Andoh, D., Narita, T., Seki, M. Hirano, Y., Narita, K., Kuraoka, I., Hiraoka, Y. and Tanaka, K. (2010) MMXD, a TFIIH-independent XPD-MMS19 protein complex involved in chromosome segregation. Mol. Cell, 39: 632-640.
  5. Kawai-Noma S, Pack C-G, Kojidani T, Asakawa H, Hiraoka Y, Kinjo M, Haraguchi T, Taguchi H, Hirata A. (2010) In vivo evidence for the fibrillar structures of Sup35 prions in yeast cells. J. Cell Biol. 190: 223-231.
  6. Capanni C, Cenni V, Haraguchi T, Squarzoni S, Ogris E, Novelli G, Maraldi NM, Lattanzi G. (2010) Lamin A precursor induces barrier-to-autointegration factor nuclear localization. Cell Cycle. 9: 2600-2610.
  7. Iwamoto M, Asakawa H, Hiraoka Y and Haraguchi T. (2010) Nucleoporin Nup98: a gatekeeper in the eukaryotic kingdoms. Genes Cells. 15: 661-669.
  8. Nakano T, Shuai J, Koujin T, Suda T, Hiraoka Y, Haraguchi T. (2010) Biological Excitable Media Based on Non-excitable Cells and Calcium Signaling. Nano Communication Networks. 1: 43-49.
  9. Iwamatsu T., Haraguchi T, Nagano H. (2010) Cytoplasmic localization of DNA polymerase in oocytes of the teleost fish, Oryzias latipes. Bulletin of Aichi University of Education. 59: 43-50.
  10. Kelly AE, Ghenoiu C, Xue JZ, Zierhut C, Kimura H, and Funabiki H (2010) Survivin reads phosphorylated histone H3 threonine 3 to activate the mitotic kinase Aurora B. Science 330, 235-239.
  11. Inagaki S, Miura-Kamio A, Nakamura Y, Lu F, Cui X, Cao X, Kimura H, Saze H, and Kakutani T (2010) Autocatalytic differentiation of epigenetic modifications within the Arabidopsis genome. EMBO J. 29, 3496-506.
  12. Rechtsteiner A, Ercan S, Takasaki T, Phippen TM, Egelhofer T, Wang W, Kimura, H, Lieb JD, and Strome S (2010) Epigenetic role of a histone H3K36 methyltransferase in propagating the memory of germline gene expression. PLoS Genet. 6, e1001091.
  13. Reynoird N, Schwartz BE, Delvecchio M, Sadoul K, Meyers D, Mukherjee C, Caron C, Kimura H, Rousseaux S, Cole PA, Panne D, French CA, and Khochbin S (2010) Oncogenesis by sequestration of CBP/p300 in transcriptionally inactive hyperacetylated chromatin domains. EMBO J. 29, 2943-2952.
  14. Furuhashi H, Takasaki T, Rechtsteiner A, Li T, Kimura H, Strome S, Checchi PM, and Kelly WG (2010) Trans-generational epigenetic regulation of C. elegans primordial germ cells. Epigenetics Chromatin 3, 15.
  15. Nozawa R-S, Nagao K, Masuda H-T, Iwasaki O, Hirota T, Nozaki N, Kimura H, and Obuse C (2010) Human POGZ modulates HP1 dissociation from mitotic chromosome arms through Aurora B activation. Nat. Cell Biol. 12, 719-727.
  16. Tachiwana H, Kagawa W, Osakabe A, Kawaguchi K., Shiga T, Hayashi-Takanaka Y, Kimura H, and *Kurumizaka H (2010)  Structural basis of instability of the nucleosome containing a testis-specific histone variant, human H3T. Proc. Natl. Acad. Sci. USA 107, 10454-10459.
  17. Matsui T., Leung D., Miyashita H., Maksakova I.A., Miyachi H., Kimura H., Tachibana M., Lorincz M.C., and Shinkai, Y. (2010) Proviral silencing in embryonic stem cells requires the histone methyltransferase ESET. Nature  464, 927-931
  18. Kimura H., Hayashi-Takanaka Y., and Yamagata K.(2010) Visualization of DNA methylation and histone modifications in living cells. Curr. Opin. Cell Biol. 22(3), 412-418
  19. Hashimoto H., Takami Y., Sonoda E., Iwasaki T., Iwano H., Tachibana M., Takeda S., Nakayama T., Kimura H., and Shinkai Y. (2010) Histone H1 null vertebrate cells exhibit altered nucleosome architecture. Nucleic Acids Res. 38, 3533-3545
  20. Ding DQ, Haraguchi T, Hiraoka Y. (2010) From meiosis to postmeiotic events: alignment and recognition of homologous chromosomes in meiosis. The FEBS J. 277(3),565-70
  21. Kobayashi S., Kojidani T., Osakada H., Yamamoto A., Yoshimori T., Hiraoka Y., and Haraguchi T. (2010) Artificial induction of autophagy around polystyrene beads in nonphagocytic cells. Autophagy 6(1),36-45