Graduate School of Frontier Biosciences, Osaka University

Japanese

Research Highlight

Dendritic spine dynamics in synaptogenesis after repeated LTP inductions: Dependence on pre-existing spine density.

Journal Scientific Reports 3, 1957 (2013)
Authors Yuki Oe (1, 2), Keiko Tominaga-Yoshino (1), Sho Hasegawa (1) & Akihiko Ogura (1)

  1. Department of Neuroscience, Osaka University Graduate School of Frontier Biosciences, Yamadaoka 1-3, Suita 565-0871 Osaka, Japan
  2. Current address: RIKEN Brain Science Institure, Hirosawa 2-1, Wako 351-0198 Saitama, Japan
Title Dendritic spine dynamics in synaptogenesis after repeated LTP inductions: Dependence on pre-existing spine density.
PubMed 23739837
Laboratory Synaptic Plasticity Group 〈Prof. Ogura〉
Abstract Not only from our daily experience but from learning experiments in animals, we know that the establishment of long-lasting memory requires repeated practice. However, cellular backgrounds underlying this repetition-dependent consolidation of memory remain largely unclear. We reported previously using organotypic slice cultures of rodent hippocampus that the repeated inductions of LTP (long-term potentiation) lead to a slowly developing long-lasting synaptic enhancement accompanied by synaptogenesis distinct from LTP itself, and proposed this phenomenon as a model system suitable for the analysis of the repetition-dependent consolidation of memory. Here we examined the dynamics of individual dendritic spines after repeated LTP-inductions and found the existence of two phases in the spines' stochastic behavior that eventually lead to the increase in spine density. This spine dynamics occurred preferentially in the dendritic segments having low pre-existing spine density. Our results may provide clues for understanding the cellular bases underlying the repetition-dependent consolidation of memory.