Graduate School of Frontier Biosciences, Osaka University

Japanese

Research Highlight

Date Description PubMed Laboratory
2015-03 Induction of DNA Methylation by Artificial piRNA Production in Male Germ Cells.

Itou D (1), Shiromoto Y (2), Shin-Ya Y (1), Ishii C (1), Nishimura T (1), Ogonuki N (3), Ogura A (3), Hasuwa H (4), Fujihara Y (4), Kuramochi-Miyagawa S (5), Nakano T (6)

  1. Department of Pathology, Graduate School of Frontier Biosciences, Osaka University, Yamada-oka 2-2 Suita, Osaka 565-0871, Japan; CREST, Japan Science and Technology Agency (JST), Saitama 332-0012, Japan.
  2. Medical School, Osaka University, Yamada-oka 2-2 Suita, Osaka 565-0871, Japan; CREST, Japan Science and Technology Agency (JST), Saitama 332-0012, Japan.
  3. RIKEN BioResources Center, Tsukuba 305-0074, Ibaraki, Japan.
  4. Research Institute for Microbial Diseases, Osaka University, Yamada-oka 2-2 Suita, Osaka 565-0871, Japan.
  5. Medical School, Osaka University, Yamada-oka 2-2 Suita, Osaka 565-0871, Japan; CREST, Japan Science and Technology Agency (JST), Saitama 332-0012, Japan.
  6. Department of Pathology, Graduate School of Frontier Biosciences, Osaka University, Yamada-oka 2-2 Suita, Osaka 565-0871, Japan; Medical School, Osaka University, Yamada-oka 2-2 Suita, Osaka 565-0871, Japan; CREST, Japan Science and Technology Agency (JST), Saitama 332-0012, Japan.


Curr Biol 25, 901-906 (2015)
25772451 Laboratory of Stem Cell Pathology 〈Prof. Nakano〉
2015-02 DNA methyltransferase 3a regulates osteoclast differentiation by coupling to an S-adenosylmethionine-producing metabolic pathway.

Nishikawa K (1), Iwamoto Y (2), Kobayashi Y (3), Katsuoka F (4), Kawaguchi S (5), Tsujita T (6), Nakamura T (7), Kato S (8), Yamamoto M (4), Takayanagi H (9), Ishii M (1)

    • Department of Immunology and Cell Biology, Graduate School of Medicine and Frontier Biosciences, Osaka University, Osaka, Japan.
    • WPI-Immunology Frontier Research Center, Osaka University, Osaka, Japan.
    • Japan Science and Technology Agency, CREST, Tokyo, Japan.

    • Department of Immunology and Cell Biology, Graduate School of Medicine and Frontier Biosciences, Osaka University, Osaka, Japan.
    • WPI-Immunology Frontier Research Center, Osaka University, Osaka, Japan.
    • Japan Science and Technology Agency, CREST, Tokyo, Japan.
    • Department of Otorhinolaryngology-Head and Neck Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan.
  1. Institute for Oral Science, Matsumoto Dental University, Nagano, Japan.

    • Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
    • Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan.
  2. Department of Molecular Medicine and Therapy, Tohoku University Graduate School of Medicine, Sendai, Japan.
  3. Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan.
  4. Department of Biochemistry, School of Medicine, Keio University, Tokyo, Japan.
  5. Soma Central Hospital, Fukushima, Japan.
    • Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Tokyo, Japan.
    • Japan Science and Technology Agency, ERATO, Takayanagi Osteonetwork Project, Tokyo, Japan.


Nature Medicine 21, 281-287 (2015)
25706873 Laboratory of Immunology and Cell Biology 〈Prof. Ishii〉
2015-01 Augmented AMPK activity inhibits cell migration by phosphorylating the novel substrate Pdlim5.

Yan Y. (1), Tsukamoto O. (1), Nakano A. (2), Kato H. (1), Kioka H. (3), Ito N. (3), Higo S. (3), Yamazaki S. (4), Shintani Y. (1), Matsuoka K. (3), Liao Y. (5), Asanuma H. (2), Asakura M. (2), Takafuji K. (6), Minamino T. (3), Asano Y. (3), Kitakaze M. (2), Takashima S. (7, 8)

  1. Department of Medical Biochemistry, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan
  2. Depertment of Clinical Research and Development, National Cerebral and Cardiovascular Center Research Institute, Suita, Osaka 565-8565, Japan
  3. Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan
  4. Department of Cell Biology, National Cerebral and Cardiovascular Center Research Institute, Suita, Osaka 565-8565, Japan
  5. Department of Cardiology, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, 510515 Guangzhou, China
  6. Center for Research Education, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan
  7. Department of Medical Biochemistry, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan
  8. Japan Science and Technology Agency-Core Research for Evolutional Science and Technology (CREST), Kawaguchi 332-0012, Japan


Nat Commun 30, 6137 (2015)
25635515 Department of Medical Biochemistry 〈Prof. Takashima〉
2015-01 Higd1a is a positive regulator of cytochrome c oxidase.

Hayashi T. (1), Asano Y. (2), Shintani Y. (3), Aoyama H. (4), Kioka H. (5), Tsukamoto O. (3), Hikita M. (6), Shinzawa-Itoh K. (6), Takafuji K. (7), Higo S. (1), Kato H. (3), Yamazaki S. (8), Matsuoka K. (5), Nakano A. (9), Asanuma H. (10), Asakura M. (9), Minamino T. (5), Goto Y. (11), Ogura T. (6), Kitakaze M. (9), Komuro I. (12), Sakata Y. (5), Tsukihara T. (13), Yoshikawa S. (6), Takashima S. (14)

  1. Departments of Medical Biochemistry and Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan
  2. Departments of Medical Biochemistry and Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan
  3. Departments of Medical Biochemistry, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan
  4. Graduate School of Pharmaceutical Science, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan
  5. Cardiovascular Medicine, University of Hyogo, 3-2-1 Kouto, Kamigohri, Akoh, Hyogo 678-1297, Japan
  6. Department of Life Science, University of Hyogo, 3-2-1 Kouto, Kamigohri, Akoh, Hyogo 678-1297, Japan
  7. Center for Research Education, National Cerebral and Cardiovascular Center Research Institute, Suita, Osaka 565-8565, Japan
  8. Departments of Cell Biology, National Cerebral and Cardiovascular Center Research Institute, Suita, Osaka 565-8565, Japan
  9. Clinical Research and Development, National Cerebral and Cardiovascular Center Research Institute, Suita, Osaka 565-8565, Japan
  10. Department of Cardiovascular Science and Technology, Kyoto Prefectural University School of Medicine, Kamigyo-ku, Kyoto 602-8566, Japan
  11. Department of Child Neurology, National Center Hospital of Neurology and Psychiatry, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187-8502, Japan
  12. Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Tokyo 113-8656, Japan
  13. Department of Life Science, University of Hyogo, 3-2-1 Kouto, Kamigohri, Akoh, Hyogo 678-1297, Japan; Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Kawaguchi, Saitama 332-0012, Japan
  14. Departments of Medical Biochemistry and Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Kawaguchi, Saitama 332-0012, Japan


Proc Natl Acad Sci USA 112, 1553–1558 (2015)
25605899 Department of Medical Biochemistry 〈Prof. Takashima〉
2014-12 The Role of T-cadherin in Axonal Pathway Formation in Neocortical Circuits.

Hayano Y. (1), Zhao H. (1), Kobayashi H. (1), Takeuchi K. (2), Norioka S. (3), Yamamoto N. (1)

  1. Neuroscience Laboratories, Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamadaoka, Suita, Osaka 565-0871, Japan
  2. Department of Biology, Aichi Medical University, Karimata-Yazako, Nagakute, Aichi 480-1195, Japan
  3. Laboratories of Biomolecular Networks, Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamadaoka, Suita, Osaka 565-0871, Japan


Development 141, 4784-93 (2014)
25468941 Cellular and Molecular Neurobiology Group 〈Prof. Yamamoto〉
2014-10 Netrin-4 Regulates Thalamocortical Axon Branching in an Activity-Dependent Fashion

Hayano Y. (1, 3), Sasaki K. (1), Ohmura N. (2), Takemoto M. (1), Maeda Y. (1), Yamashita T. (3), Hata Y. (2), Kitada K. (4), Yamamoto N. (1)

  1. Laboratory of Cellular and Molecular Neurobiology, Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka 565-0871, Japan
  2. Division of Integrative Bioscience, Institute of Regenerative Medicine and Biofunction, Tottori University Graduate School of Medical Sciences, 86 Nishicho Yonago, 683-8503, Japan
  3. Department of Molecular Neuroscience, Graduate School of Medicine, Osaka University, Suita, Osaka 565-0871, Japan
  4. Laboratory of Mammalian Genetics, Division of Genome Dynamics, Creative Research Initiative ''Sousei'', Hokkaido University, North 10 West 8, Kita-ku, Sapporo 060-0810, Japan


Proc Natl Acad Sci USA 111, 15226-15231 (2014)
25288737 Cellular and Molecular Neurobiology Group 〈Prof. Yamamoto〉
2014-09 Regulation of RNA polymerase II activation by histone acetylation in single living cells

Stasevich TJ (1, 2, 3), Hayashi-Takanaka Y (1, 4, 5), Sato Y (1, 5), Maehara K (6), Ohkawa Y (4, 6), Sakata-Sogawa K (7, 8), Tokunaga M (7, 8), Nagase T (9), Nozaki N (10), McNally JG (11, 12), Kimura H (1, 4, 5)

  1. Graduate School of Frontier Biosciences, Osaka University, Osaka, 565-0871, Japan
  2. Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, Colorado 80523-1870, USA
  3. Transcription Imaging Consortium, Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia 20147, USA
  4. Japan Science and Technology Agency (JST), Core Research for Evolutional Science and Technology (CREST), Kawaguchi, Saitama, 332-0012, Japan
  5. Department of Biological Sciences, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama, 226-8501, Japan
  6. Department of Advanced Medical Initiatives, Faculty of Medicine, Kyushu University, Fukuoka, 812-8582, Japan
  7. Department of Biological Information, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama, 226-8501, Japan
  8. RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, 230-0045, Japan
  9. Department of Biotechnology Research, Kazusa DNA Research Institute, Chiba, 292-0818, Japan
  10. Mab Institute Inc., Sapporo, 001-0021, Japan
  11. Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
  12. Institute for Soft Matter and Functional Materials, Helmholtz Zentrum Berlin, Berlin, 14109, Germany


Nature 516, 272-275 (2014)
25252976 Nuclear Dynamics Group 〈Prof. Hiraoka〉
2014-04 Developmental epigenetic modification regulates stochastic expression of clustered protocadherin genes, generating single neuron diversity.

Toyoda S. (1, 2), Kawaguchi M. (1), Kobayashi T. (3, 4), Tarusawa E. (2, 5), Toyama T. (1), Okano M. (6), Oda M. (6), Nakauchi H. (3, 4), Yoshimura Y. (5, 7), Sanbo M. (2, 8), Hirabayashi M. (2, 7, 8), Hirayama T. (1, 2), Hirabayashi T. (1, 2), Yagi T. (1, 2)

  1. KOKORO-Biology Group, Laboratories for Integrated Biology, Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamadaoka, Suita, Osaka 565-0871, Japan
  2. Japan Science and Technology Agency-Core Research for Evolutional Science and Technology, CREST, Osaka University, 1-3 Yamadaoka, Suita, Osaka 565-0871, Japan
  3. Division of Stem Cell Therapy, Center for Stem Cell Biology and Regenerative Medicine, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan
  4. Japan Science Technology Agency, ERATO, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan
  5. Division of Developmental Neurophysiology, National Institute for Physiological Sciences, National Institutes of Natural Sciences, Okazaki, Aichi 444-8787, Japan
  6. Laboratory for Mammalian Epigenetic Studies, RIKEN Center for Developmental Biology, Minatojima-minamimachi 2-2-3, Chuo-ku, Kobe, Hyogo 650-0047, Japan
  7. Department of Physiological Sciences, The Graduate University for Advanced Studies, Okazaki, Aichi 444-8585, Japan
  8. Section of Mammalian Transgenesis, Center for Genetic Analysis of Behavior, National Institute for Physiological Sciences, Okazaki, Aichi 444-8585, Japan


Neuron 82, 94-108 (2014)
24698270 KOKORO-Biology Group 〈Prof. Yagi〉