Graduate School of Frontier Biosciences, Osaka University

Japanese

The Role of T-cadherin in Axonal Pathway Formation in Neocortical Circuits.

Journal Development 141, 4784-93 (2014)
Authors Hayano Y. (1), Zhao H. (1), Kobayashi H. (1), Takeuchi K. (2), Norioka S. (3), Yamamoto N. (1)

  1. Neuroscience Laboratories, Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamadaoka, Suita, Osaka 565-0871, Japan
  2. Department of Biology, Aichi Medical University, Karimata-Yazako, Nagakute, Aichi 480-1195, Japan
  3. Laboratories of Biomolecular Networks, Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamadaoka, Suita, Osaka 565-0871, Japan
Title The Role of T-cadherin in Axonal Pathway Formation in Neocortical Circuits.
PubMed 25468941
Laboratory Cellular and Molecular Neurobiology Group 〈Prof. Yamamoto〉
Description Cortical efferent and afferent fibers are arranged in a stereotyped pattern in the intermediate zone (IZ). Here, we studied the mechanism of axonal pathway formation by identifying a molecule that is expressed in a subset of cortical axons in the rat. We found that T-cadherin (T-cad), a member of the cadherin family, is expressed in deep-layer cell axons projecting to subcortical structures, but not in upper layer callosal axons projecting to the contralateral cortex. Ectopic expression of T-cad in upper layer cells induced axons to project toward subcortical structures via the upper part of the IZ. Moreover, the axons of deep-layer cells in which T-cad expression was suppressed by RNAi projected towards the contralateral cortex via an aberrant route. These results suggest that T-cad is involved in axonal pathway formation in the developing cortex.