Graduate School of Frontier Biosciences, Osaka University

Japanese

Aneuploidy Drives Genomic Instability in Yeast

Journal Science 333, 1026-1030 (2011)
Authors Jason M. Sheltzer (1), Heidi M. Blank (1), Sarah J. Pfau (1), Yoshie Tange (2), Benson M. George (1), Timothy J. Humpton (1), Ilana L. Brito (3), Yasushi Hiraoka (2, 4), Osami Niwa (5) and Angelika Amon (1)
  1. David H. Koch Institute for Integrative Cancer Research and Howard Hughes Medical Institute (HHMI)
  2. Graduate School of Frontier Biosciences, Osaka University
  3. Department of Ecology, Evolution and Environmental Biology, Columbia University
  4. Kobe Advanced ICT Research Center, National Institute of Information and Communications Technology
  5. The Rockefeller University
Title Aneuploidy Drives Genomic Instability in Yeast
PubMed 21852501
Laboratory Nuclear Dynamics Group 〈Prof. Hiraoka〉
Abstract Aneuploidy decreases cellular fitness, yet it is also associated with cancer, a disease of enhanced proliferative capacity. To investigate one mechanism by which aneuploidy could contribute to tumorigenesis, we examined the effects of aneuploidy on genomic stability. We analyzed 13 budding yeast strains that carry extra copies of single chromosomes and found that all aneuploid strains exhibited one or more forms of genomic instability. Most strains displayed increased chromosome loss and mitotic recombination, as well as defective DNA damage repair. Aneuploid fission yeast strains also exhibited defects in mitotic recombination. Aneuploidy-induced genomic instability could facilitate the development of genetic alterations that drive malignant growth in cancer.