Graduate School of Frontier Biosciences, Osaka University

Japanese

Research Highlight

Date Description PubMed Laboratory
2017-02 Genetically encoded bioluminescent voltage indicator for multi-purpose use in wide range of bioimaging

Inagaki S (1), Tsutsui H (2, 3), Suzuki K (4), Agetsuma M (5), Arai Y (5), Jinno Y (3), Bai G (5), Daniels MJ (6), Okamura Y (1, 3), Matsuda T (5), Nagai T (1, 4, 5).
  1. Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamadaoka, Suita, Osaka 565-0871, Japan.
  2. Department of Material Science, Japan Advanced Institute of Science and Technology, 1-1 Asahidai, Nomi, Ishikawa 923-1292, Japan.
  3. Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.
  4. Department of Biotechnology, Osaka University, 2-1 Yamadaoka, Suita, Osaka, 565-0871, Japan.
  5. The Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka 567-0047, Japan.
  6. BHF Centre for Regenerative Medicine, Division of Cardiovascular Medicine, West Wing Level 6, John Radcliffe Hospital, Oxford, OX3 9DU, UK.


Sci Rep 7, 42398 (2017)
28205521
2017-01 Identical folds used for distinct mechanical functions of the bacterial flagellar rod and hook

Fujii T (1, 2), Kato T (1), Hiraoka KD (1), Miyata T (1), Minamino T (1), Chevance FF (3), Hughes KT (3), Namba K (1, 2)
  1. Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamadaoka, Suita, Osaka 565-0871, Japan.
  2. li>Riken Quantitative Biology Center, 1-3 Yamadaoka, Suita, Osaka 565-0871, Japan.li>Department of Biology, University of Utah, Salt Lake City, Utah 84112, USA.


Nat Commun 8, 14276 (2017)
28120828 Protonic NanoMachine Group 〈Prof. Namba〉
2017-01 Effects of forced movements on learning: Findings from a choice reaction time task in rats

Kaneko H (1), Sano H (1), Hasegawa Y (2), Tamura H (3), Suzuki S (1)
  1. National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan
  2. University of Tsukuba, Tsukuba, Japan
  3. Osaka University, Suita, Japan


Learn Behav, in press (2017)
28091814 Cognitive Neuroscience Group 〈Prof. Fujita〉
2017-01 Structure of actomyosin rigour complex at 5.2-Å resolution and insights into the ATPase cycle mechanism

Fujii T (1, 2), Namba K (1, 2).
  1. Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka, Japan.
  2. Quantitative Biology Center, RIKEN, Suita, Osaka, Japan.


Nat Commun 8, 13969 (2017)
28067235 Protonic NanoMachine Group 〈Prof. Namba〉
2016-12 Noradrenaline Improves Behavioral Contrast Sensitivity via the β-Adrenergic Receptor.

Mizuyama R (1), Soma S (2), Suemastu N (2), Shimegi S (1, 2)
  1. Laboratory of Cognitive and Behavioral Neuroscience, Graduate School of Frontier Bioscience, Osaka University, Suita, Osaka, Japan.
  2. Laboratory of Cognitive and Behavioral Neuroscience, Graduate School of Medicine, Osaka University, Toyonaka, Osaka, Japan.


PLoS One (2016)
27992510
2016-12 Constitutive centromere-associated network controls centromere drift in vertebrate cells

Hori T (1), Kagawa N (2), Toyoda A (3), Fujiyama A (3, 4), Misu S (5), Monma N (5), Makino F (1), Ikeo K (5), Fukagawa T (6).
  1. Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka 565-0871, Japan.
  2. Department of Molecular Genetics, National Institute of Genetics and The Graduate University for Advanced Studies (SOKENDAI), Mishima, Shizuoka 411-8540, Japan.
  3. Comparative Genomics Laboratory, National Institute of Genetics, Mishima, Shizuoka 411-8540, Japan.
  4. National Institute of Informatics, Chiyoda-ku, Tokyo 101-8430, Japan.
  5. DNA Data Analysis Laboratory, National Institute of Genetics, Mishima, Shizuoka 411-8540, Japan.
  6. Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka 565-0871, Japan tfukagawa@fbs.osaka-u.ac.jp.


J Cell Biol 216, 101-113 (2017)
27940888 Laboratory of Chromosome Biology 〈Prof. Fukagawa〉
2016-12 High-resolution pH imaging of living bacterial cell to detect local pH differences

Morimoto YV (1, 2), Kami-Ike N (1), Miyata T (1), Kawamoto A (1), Kato T (1), Namba K (3, 2), Minamino T (3).
  1. Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka, Japan.
  2. Quantitative Biology Center, RIKEN, Suita, Osaka, Japan.
  3. Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka, Japan keiichi@fbs.osaka-u.ac.jp tohru@fbs.osaka-u.ac.jp.



mBio, e01911-16 (2016)
27923921 Protonic NanoMachine Group 〈Prof. Namba〉
2016-12 Establishment of high reciprocal connectivity between clonal cortical neurons is regulated by the Dnmt3b DNA methyltransferase and clustered protocadherins

Tarusawa E (1, 2), Sanbo M (3), Okayama A (4), Miyashita T (1), Kitsukawa T (2, 4), Hirayama T (2, 4), Hirabayashi T (2, 4), Hasegawa S (2, 4), Kaneko R (5), Toyoda S (2, 4), Kobayashi T (6), Kato-Itoh M (6), Nakauchi H (6, 7), Hirabayashi M (2, 3, 8), Yagi T (9, 10), Yoshimura Y (11, 12).
  1. Section of Visual Information Processing, National Institute for Physiological Sciences, National Institutes of Natural Sciences, Okazaki, Aichi, 444-8585, Japan.
  2. AMED-CREST, AMED, 1-3 Yamadaoka, Suita, 565-0871, Osaka, Japan.
  3. National Institute for Physiological Sciences, Section of Mammalian Transgenesis, Center for Genetic Analysis of Behavior, Okazaki, Aichi, 444-8787, Japan.
  4. KOKORO-Biology Group, Laboratories for Integrated Biology, Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamadaoka, Suita, Osaka, 565-0871, Japan.
  5. Bioresource Center, Gunma University Graduate School of Medicine, Maebashi, 371-8511, Japan.
  6. Division of Stem Cell Therapy, Center for Stem Cell Biology and Regenerative Medicine, Institute of Medical Science, University of Tokyo, Tokyo, 108-8639, Japan.
  7. Department of Genetics, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, 291 Campus Drive, Li Ka Shing Building, Stanford, CA, 94305-5101, USA.
  8. Department of Physiological Sciences, The Graduate University for Advanced Studies (SOKENDAI), Okazaki, Aichi, 444-8585, Japan.
  9. AMED-CREST, AMED, 1-3 Yamadaoka, Suita, 565-0871, Osaka, Japan. yagi@fbs.osaka-u.ac.jp.
  10. KOKORO-Biology Group, Laboratories for Integrated Biology, Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamadaoka, Suita, Osaka, 565-0871, Japan. yagi@fbs.osaka-u.ac.jp.
  11. Section of Visual Information Processing, National Institute for Physiological Sciences, National Institutes of Natural Sciences, Okazaki, Aichi, 444-8585, Japan. yumikoy@nips.ac.jp.
  12. Department of Physiological Sciences, The Graduate University for Advanced Studies (SOKENDAI), Okazaki, Aichi, 444-8585, Japan. yumikoy@nips.ac.jp.


BMC Biol 14, 103 (2016)
27912755 KOKORO-Biology Group 〈Prof. Yagi〉
2016-11 Acetylation of histone H4 Lysine 5 and 12 is required for CENP-A deposition into centromeres

Shang WH (1), Hori T (1), Westhorpe FG (2), Godek KM (3), Toyoda A (4), Misu S (5), Monma N (5), Ikeo K (5), Carroll CW (6), Takami Y (7), Fujiyama A (4, 8), Kimura H (9), Straight AF (2), Fukagawa T (1).
  1. Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka 565-0871, Japan.
  2. Department of Biochemistry, Stanford University Medical School, 259 Campus Drive, Beckman B409, Stanford, California 94305, USA.
  3. Department of Biochemistry, Geisel School of Medicine, Dartmouth College, HB7200, Hanover, New Hampshire 03755, USA.
  4. Comparative Genomics Laboratory, National Institute of Genetics, Mishima, Shizuoka 411-8540, Japan.
  5. -DNA Data Analysis Laboratory, National Institute of Genetics, Mishima, Shizuoka 411-8540, Japan.
  6. Department of Cell Biology, Yale University School of Medicine, SHM C-230, 333 Cedar St., New Haven, Connecticut 06520, USA.
  7. Section of Biochemistry and Molecular Biology, Department of Medical Sciences, University of Miyazaki, 5200, Kihara, Kiyotake, Miyazaki 889-1692, Japan.
  8. National Institute of Informatics, Hitotsubashi, Chiyoda-ku, Tokyo 101-8430, Japan.
  9. Cell Biology Unit, Institute of Innovative Research, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8501, Japan.


Nat Commun 7, 13465 (2016)
27811920 Laboratory of Chromosome Biology 〈Prof. Fukagawa〉
2016-11 Activity-Dependent Dynamics of the Transcription Factor CREB in Cortical Neurons Revealed by Single-Molecule Imaging

Kitagawa H (1), Sugo N (1), Morimatsu M (1), Arai Y (1), Yanagida T (1, 3), Yamamoto N (2).
  1. Graduate School of Frontier Biosciences, Osaka University, Osaka, Japan.
  2. Riken Quantitative Biological Center (QBiC), Osaka, Japan.


J Neurosci, in press (2016)
27810932 Cellular and Molecular Neurobiology Group 〈Prof. Yamamoto〉
2016-09 Rubicon inhibits autophagy and accelerates hepatocyte apoptosis and lipid accumulation in nonalcoholic fatty liver disease

Satoshi Tanaka (1), Hayato Hikita (1), Tomohide Tatsumi (1), Ryotaro Sakamori (1), Yasutoshi Nozaki (1), Sadatsugu Sakane (1), Yuto Shiode (1), Tasuku Nakabori (1), Yoshinobu Saito (1), Naoki Hiramatsu (1), Keisuke Tabata (2), Tsuyoshi Kawabata (2), Maho Hamasaki (2), Hidetoshi Eguchi (3), Hiroaki Nagano (3), Tamotsu Yoshimori (2), Tetsuo Takehara (1)
  1. Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, 565-0871, Osaka, Japan
  2. Department of Genetics, Osaka University Graduate School of Medicine, Suita, 565-0871, Osaka, Japan
  3. Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Suita, 565-0871, Osaka, Japan


Hepatology 64, 1994-2014 (2016)
27637015 Laboratory of Intracellular Membrane Dynamics 〈Prof. Yoshimori〉
2016-08 Surface Kondo Effect and Non-Trivial Metallic State of the Kondo Insulator YbB12

Kenta Hagiwara (1), Yoshiyuki Ohtsubo (1, 2), Masaharu Matsunami (3), Shin-ichiro Ideta (3), Kiyohisa Tanaka (3), Hidetoshi Miyazaki (3), Julien Rault (4), Patrick Le Fèvre (4), François Bertran (4), Amina Taleb-Ibrahimi (4, 5), Ryu Yukawa (6), Masaki Kobayashi (6), Koji Horiba (6), Hiroshi Kumigashira (6), Kazuki Sumida (7), Taichi Okuda (8), Fumitoshi Iga (9) and Shin-ichi Kimura (1, 2)
  1. Department of Physics, Graduate School of Science, Osaka University, Toyonaka 560-0043, Japan
  2. Graduate School of Frontier Biosciences, Osaka University, Suita 565-0871, Japan
  3. UVSOR Facility, Institute for Molecular Science, Okazaki 444-8585, Japan
  4. Synchrotron SOLEIL, Saint-Aubin-BP 48, F-91192 Gif sur Yvette, France
  5. UR1/CNRS-Synchrotron SOLEIL, Saint-Aubin, F-91192 Gif sur Yvette, France
  6. Photon Factory, Institute of Materials Structure Science, High Energy Accelerator Research Organization (KEK), 1-1 Oho, Tsukuba 305-0801, Japan
  7. Graduate School of Science, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima 739-8526, Japan
  8. HiSOR, Hiroshima University, Higashi-Hiroshima 739-0046, Japan
  9. College of Science, Ibaraki University, Mito 310-8512, Japan


Nat Commun 7, 12690 (2016)
27576449 Photophysics Laboratory 〈Prof. Kimura〉
2016-08 The tetrameric MotA complex as the core of the flagellar motor stator from hyperthermophilic bacterium

Norihiro Takekawa (1), Naoya Terahara (2), Takayuki Kato (2), Mizuki Gohara (1), Kouta Mayanagi (3), Atsushi Hijikata (4), Yasuhiro Onoue (1), Seiji Kojima (1), Tsuyoshi Shirai (4), Keiichi Namba (2), Michio Homma (1)
  1. Division of Biological Science, Graduate School of Science, Nagoya University, Chikusa-ku, Nagoya 464-8602, Japan
  2. Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamadaoka, Suita, Osaka 565-0871, Japan
  3. Medical Institute of Bioregulation, Kyushu University, Higashi-ku, Fukuoka 812-8581, Japan; JST, PRESTO, Fukuoka 812-8582, Japan
  4. Department of Bioscience, Nagahama Institute of BioScience and Technology, 1266 Tamura, Nagahama, 526-0829, Japan


Sci Rep 6, 31526 (2016)
27531865 Protonic NanoMachine Group 〈Prof. Namba〉
2016-07 Autophagosome-lysosome fusion in neurons requires INPP5E, a protein associated with Joubert syndrome

Hasegawa J (1), Iwamoto R (2), Otomo T (3), Nezu A (3), Hamasaki M (1), Yoshimori T (4).
  1. Laboratory of Intracellular Membrane Dynamics, Graduate School of Frontier Biosciences Osaka University, Osaka, Japan Department of Genetics, Graduate School of Medicine Osaka University, Osaka, Japan.
  2. Laboratory of Intracellular Membrane Dynamics, Graduate School of Frontier Biosciences Osaka University, Osaka, Japan.
  3. Department of Genetics, Graduate School of Medicine Osaka University, Osaka, Japan.
  4. Laboratory of Intracellular Membrane Dynamics, Graduate School of Frontier Biosciences Osaka University, Osaka, Japan Department of Genetics, Graduate School of Medicine Osaka University, Osaka, Japan
    tamyoshi@fbs.osaka-u.ac.jp.


EMBO J, e201593148 (2016)
27340123 Laboratory of Intracellular Membrane Dynamics 〈Prof. Yoshimori〉
2016-06 Depletion of autophagy receptor p62/SQSTM1 enhances the efficiency of gene delivery in mammalian cells

Tsuchiya M (1), Ogawa H (1, 2), Koujin T (2), Kobayashi S (2), Mori C (2), Hiraoka Y (1, 2), Haraguchi T (1, 2).
  1. Graduate School of Frontier Biosciences, Osaka University, Suita, Japan.
  2. Advanced ICT Research Institute Kobe, National Institute of Information and Communications Technology, Kobe, Japan.


FEBS LETT 590, 2671-2680 (2016)
27317902 Nuclear Dynamics Group 〈Prof. Hiraoka〉
2016-06 Effects of generalized pooling on binocular disparity selectivity of neurons in the early visual cortex.

Daisuke Kato (1), Mika Baba (1, 2), Kota S Sasaki (1, 3), Izumi Ohzawa (1, 3)
  1. Viaual Neuroscience Laboratory, Graduate School of Frontier Biosciences, Osaka University, 1-4 Yamadaoka, Suita, Osaka 565-0871, Japan
  2. National Institute for Physiological Sciences, Okazaki, Aichi 444-8585, Japan
  3. Center for Information and Neural Networks, Osaka University and National Institute of Information and Communications Technology, 1-4 Yamdaoka, Suita, Osaka 565-0871, Japan


Phil. Trans. R. Soc. B 371: 20150266 (2016)
27269609 Visual Neuroscience Laboratory 〈Prof. Ohzawa〉
2016-05 Error signals in motor cortices drive adaptation in reaching

Inoue M (1), Uchimura M (2), Kitazawa S (3)

  1. Center for Information and Neural Networks (CiNet), National Institute of Information and Communications Technology, and Osaka University, Yamadaoka 1-4, Suita, Osaka, 565-0871, Japan; Department of Neurophysiology, Juntendo University School of Medicine, Hongo 2-1-1, Bunkyo, Tokyo 113-8421, Japan. Electronic address: msinoue@nict.go.jp.
  2. Dynamic Brain Network Laboratory, Graduate School of Frontier Biosciences, Osaka University, Yamadaoka 1-3, Suita, Osaka 565-0871, Japan.
  3. Center for Information and Neural Networks (CiNet), National Institute of Information and Communications Technology, and Osaka University, Yamadaoka 1-4, Suita, Osaka, 565-0871, Japan; Department of Neurophysiology, Juntendo University School of Medicine, Hongo 2-1-1, Bunkyo, Tokyo 113-8421, Japan; Dynamic Brain Network Laboratory, Graduate School of Frontier Biosciences, Osaka University, Yamadaoka 1-3, Suita, Osaka 565-0871, Japan; Department of Brain Physiology, Graduate School of Medicine, Osaka University, Yamadaoka 1-3, Suita, Osaka 565-0871, Japan. Electronic address: kitazawa@fbs.osaka-u.ac.jp.


Neuron 90, 1114-1126 (2016)
27181058 Dynamic Brain Network Laboratory 〈Prof. Kitazawa〉
2016-04 Periodicity in attachment organelle revealed by electron cryotomography suggests conformational changes in gliding mechanism of Mycoplasma pneumoniae

Kawamoto A (1), Matsuo L (2), Kato T (1), Yamamoto H (2), Namba K (3), Miyata M (4)

  1. Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka, Japan
  2. Department of Biology, Graduate School of Science, Osaka City University, Sumiyoshi-ku, Osaka, Japan
  3. Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka, Japan Riken Quantitative Biology Center, Suita, Osaka, Japan
  4. Department of Biology, Graduate School of Science, Osaka City University, Sumiyoshi-ku, Osaka, Japan The OCU Advanced Research Institute for Natural Science and Technology (OCARINA), Osaka City University, Sumiyoshi, Osaka, Japan


mBio 7, e00243-16 (2016)
27073090 Protonic NanoMachine Group 〈Prof. Namba〉
2016-04 Blink and you'll miss it: the role of blinking in the perception of magic tricks

Wiseman RJ (​1), Nakano T (2)

  1. Psychology, University of Hertfordshire, Hatfield, United Kingdom
  2. Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka, Japan


PeerJ 4, e1873 (2016)
27069808 Dynamic Brain Network Laboratory 〈Prof. Kitazawa〉