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”hŒ­–Ϊ“IF1. 10th International Workshop on "Single Molecule Detection and Ultra Sensitive Analysis in the Life Sciences"‚ΙŽQ‰Α‚΅A¬‰Κ”­•\Aξ•ρŽϋW(Germany)@2.Wolfson Institute for Biomedical Research University College London(U.K.)‚Ι‚ΔŒ€‹†‘Ε‚Ώ‡‚ν‚Ή@3.Laboratoire de Physique de la Matiere Condensee de l'Ecole Normale Superieure‚Ι‚ΔŒ€‹†‘Ε‚Ώ‡‚ν‚Ή(France)




1. Title Report on (1) the presentation at the 10th International Workshop on gSingle Molecule at Detection and Ultrasensitive Analysis in Life Scienceh, (2) the disscussion with our collaboration research group at UCL, (3) the presentation and discussion to the research group at ENS.

2. Name Yoshikazu Tsukasaki

3. Affiliation Department of Mesoscopic Materials Science, Graduate School of Materials Science, NAIST

4. Destination
(1) 10th International Workshop on "Single Molecule Detection and Ultra Sensitive Analysis in the Life Sciences" at WISTA Campus, Berlin, Germany
(2) Wolfson Institute for Biomedical Research University College London (UCL), London, UK
(3) Laboratoire de Physique de la Matiere Condensee de l'Ecole Normale Superieure (ENS), Paris, France

5. Outline of the trip
Purpose of the trip
(1) to present our recent results and discuss at the workshop to think about the direction of our future research and regarding for new single molecule detection technique
(2) to discuss the paper writing now with our coauthor at UCL
(3) to present our results and discuss a physical model with members of the physics department at ENS
Schedule of the trip
9/20 KANSAI INTERNATIONAL AIRPORT (JP) ¨ HONG KOKNG (HK) ¨ 9/21 LONDON HEATHROW AIRPORT (GB) ¨ LO NDON STANSTED AIRPORT (GB) ¨ BERLIN SCHONEFELD AIRPORT (DE)
9/22-24 WISTA Campus 9/25 BERLIN SCHONEFELD AIRPORT (DE) ¨ LONDON STANSTED AIRPORT (GB) 9/27 UCL
9/28 WATERLOO RAIL STA (GB) ¨ PARIS GARE NORD RL (FR) 9/29 ENS
9/30 PARIS CHARLES DE GAULL INTERNATIONAL (FR) ¨ 10/1 HONG KOKNG (HK) ¨ KANSAI INTERNATIONAL AIRPORT (JP)

Meeting report
The detection and spectroscopy techniques of single molecules have tremendously improved over the last decade. Optical microscopic detection methods, for example confocal microscopy, fluorescence correlation spectroscopy (FCS) and raman spectroscopy, already having shown the highest potential in a variety of applications, also have continued to be hot topics at this workshop. Recently, fluorescence resonance energy transfer(FRET) and photoinduced electron transfer(PET) have been intensely investigated by many researchers. I think that these techniques are currently the best methods to study structure and dynamics of individual molecules. However, force spectroscopy, which we have exclusively developed, has received little attention at this workshop. Consequently many researchers, including the members of laboratory I visited, were interested in our research and provided me many useful suggestions and interpretations for our physical model. From this trip, the discussions aided us in completing our manuscript for submission and provided new ideas to experimentally pursue.

Perspective and future plans
Our final aim of this research is to physically characterise the mechanism of molecule recognition and signal processing at a noisy nano-reaction-field of biomolecules. Though many SMD techniques have been improved, I think our technique is one of the better methods to achieve this aim. I will continue to investigate the properties of biomolecules using our measurement system.

Finally, I express my gratitude to the COE financial support for the trip.